Mario Maggi

Low testosterone syndrome protects from major adverse cardiovascular events in subjects at high cardiovascular burden

0,2 0,0 0,0 0,2 0,4 0,6 0,8 1,0 1-SPECIFICITY 0,0 0,2 0,4 0,6 0,8 1,0 cFT <225 pM/l T <12nM/l LOW TESTOSTERONE SYNDROME PROTECTS FROM MAJOR ADVERSE CARDIOVASCULAR EVENTS IN SUBJECTS AT HIGH CARDIOVASCULAR BURDEN E. Maseroli, G. Corona, G. Rastrelli, A. Sforza, G. Forti, E. Mannucci, M. Maggi Background. The role of testosterone (T) in cardiovascular (CV) health of men is controversial. Several data suggest that hypogonadism is associated with CV mortality but not morbidity. However, recent evidence shows that hypogonadal subjects treated with T replacement therapy have a higher incidence of major adverse CV events (MACE). The aim of this study is to analyze whether the gonadal status might predict MACE incidence according to the previous history of MACE, in a cohort of subjects complaining for sexual dysfunction. A consecutive series of 1687 patients was followed-up for a mean time of 4.3±2.6 years for new occurrence of MACE, detecting 139 events.

The FXR agonist obeticholic acid normalizes lipid droplet and triglyceride handling in visceral adipose tissue preadipocytes from a non-genomic rabbit model of metabolic syndrome

E. Maneschi, L. Vignozzi, A. Morelli, T. Mello, S. Filippi, I. Cellai, P. Comeglio, E. Sarchielli, A. Calcagno, R. Vettor, GB. Vannelli, L. Adorini and M. Maggi. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy Introduction: Adipose tissue (AT) dysfunction is characterized by ectopic fat deposition in the abdominal viscera and liver, inflammatory and adipokine dysregulation, and insulin resistance and may be a more important mediator than total fat mass of type 2 diabetes, hypertension and dyslipidaemia development, all these features clustering in the metabolic syndrome (MetS). We recently demonstrated that the selective FXR agonist obeticholic acid (OCA) ameliorates the metabolic profile and reduces visceral AT (VAT) in a high-fat diet (HFD)-induced rabbit model of MetS (1).

Sperm DNA fragmentation as assessed by TUNEL/PI: mean values in fertile men and intra individual variability

After matching for semen quality and age, sub/infertile men present greater amount of SDF than fertile ones. Such a difference is entirely due to the PI br SDF (Fig.2). Hence SDF, and in particular PI br SDF, is able to distinguish between fertile and sub/infertile subjects independently from age and semen quality. One limitation of this study is that we have no data on the female factor in the recruited infertile couples. It is possible that in a certain number of these couples, the infertility was due to a female factor and that the male partners was actually fertile. This would explain why the difference in SDF between the two groups is not so high.

Diagnosi e terapia degli stati intersessuali in età adolescenziale

RiassuntoGli “stati intersessuali”, in una accezione vasta del termine, possono essere definiti come tutte quelle condizioni in cui il sesso cromosomico, gonadico e psicologico (ovvero l’identità di genere) non sono fra loro congruenti. Tale definizione può, pertanto, comprendere, al suo interno, non solo i Disordini dello Sviluppo Sessuale propriamente detti, ma anche il disturbo d’identità di genere. Sebbene gli stati intersessuali siano nella maggioranza dei casi diagnosticati alla nascita per la presenza di genitali ambigui o atipici, in alcuni casi la diagnosi può essere posta al momento della pubertà, per un mancato sviluppo puberale o per uno sviluppo puberale atipico o ancora per il rafforzarsi di una disforia di genere. Il percorso diagnostico e terapeutico in un soggetto con sospetto stato intersessuale in età peri-puberale deve prevedere non solo l’identificazione della condizione medica di base (laddove possibile), ma anche la definizione dell’identità di genere, al fine di ottimizzare gli esiti terapeutici. Quest’ultimo sembra essere uno degli aspetti miliari dell’approccio clinico, in quanto condiziona l’induzione puberale in senso maschile o femminile. É auspicabile un approccio multidisciplinare e olistico ai giovani pazienti con stato intersessuale.