Mark Noble

LAPAROSCOPIC RETROPERITONEAL LIVE DONOR RIGHT NEPHRECTOMY FOR PURPOSES OF ALLOTRANSPLANTATION AND AUTOTRANSPLANTATION

PURPOSEnWe report the technique of and initial experience with retroperitoneal laparoscopic live donor right nephrectomy for purposes of renal allotransplantation and autotransplantation.nnnMATERIALS AND METHODSnA total of 5 patients underwent retroperitoneoscopic live donor nephrectomy of the right kidney for autotransplantation in 4 and living related renal donation in 1. Indications for autotransplantation included a large proximal ureteral tumor, a long distal ureteral stricture and 2 cases of the loin pain hematuria syndrome. In all cases a 3-port retroperitoneal laparoscopic approach and a pelvic muscle splitting Gibson incision for kidney extraction were used. In patients undergoing autotransplantation the same incision was used for subsequent transplantation.nnnRESULTSnAll procedures were successfully accomplished without technical or surgical complications. Total mean operating time was 5.8 hours and average laparoscopic donor nephrectomy time was 3.1 hours. Mean renal warm ischemia time, including endoscopic cross clamping of the renal artery to ex vivo cold perfusion, was 4 minutes. Average blood loss for the entire procedure was 400 cc. Radionuclide scan on postoperative day 1 confirmed good blood flow and function in all transplanted kidneys. Mean analgesic requirement was 58 mg. fentanyl. Mean hospital stay was 4 days (range 2 to 8), and convalescence was completed in 3 to 4 weeks.nnnCONCLUSIONSnIn the occasional patient requiring renal autotransplantation live donor nephrectomy can be performed laparoscopically with renal extraction and subsequent transplantation through a single standard extraperitoneal Gibson incision, thus, minimizing the overall operative morbidity. Furthermore, these data demonstrate that live donor nephrectomy of the right kidney can be performed safely using a retroperitoneal approach with an adequate length of the right renal vein obtained for allotransplantation or autotransplantation.

Myelolipoma: An unusual surgical lesion of the adrenal gland

The clinical and pathologic features of three cases of surgically removed myelolipoma of the adrenal gland are presented. As with 18 previously reported cases, the lesions were found in obese, middle‐aged persons; two of three had chronic, systemic disease (vasculitis and lymphoma, sustained hypertension). The only symptom possibly attributable to the neoplasm was nonspecific abdominal pain, and each lesion was identified by inferior renal displacement on intravenous urography. As computed tomography becomes widely available, the authors expect more myelolipomas to be detected that require surgical exploration, since there are no satisfactory, specific radiographic criteria to differentiate adrenal myelolipoma from adrenocortical carcinoma.

Flexible Ureteroscopy With a Ureteral Access Sheath: When to Stent?

OBJECTIVEnTo compare intra- and postoperative data of patients who underwent ureterorenoscopy (URS) with an access sheath, with and without postoperative stenting.nnnMETHODSnWe retrospectively identified patients who underwent flexible URS with a ureteral access sheath between January 2102 and January 2013. Two surgeons performed all cases; one who routinely stents after flexible ureteroscopy and a second who selectively stents. Fifty-one patients who were stented and 51 patients not stented after URS were enrolled in this study. Patients were matched by operative time as a surrogate measure of complexity of the procedure. Intra- and postoperative data were compared. We also analyzed if preoperative stenting or sheath diameter had any effect on postoperative pain score for each group.nnnRESULTSnPatients in the stented group were older (P <.001), had larger ureteral access sheaths (P <.001), and greater stone burden (P <.001). Despite this, the stented group had lower pain scores (4.5 ± 3.2 vs 8.9 ± 3.2; P = .025) and were less likely to seek medical assistance for pain than the unstented patients (26.3% vs 3.9%; P = .007). Patients who were prestented before ureteroscopy had lower pain scores than those who were not prestented in the group that did not receive a postoperative stent (4.2 ± 3.4 vs 6.6 ± 2.8; P = .047).nnnCONCLUSIONnPostoperative stenting after flexible URS with a ureteral access sheath seems to decrease postoperative pain. Patients might be selected for no ureteral stent if they were prestented before the procedure, and the URS was uneventful.

Renal Subcapsular Hematoma: A Diagnostic and Therapeutic Dilemma

Subcapsular renal hematomas have been found in 14 hypertensive patients between 17 and 66 years old. In 11 patients with chronic lesions hypertension improved more often with nephrectomy (7 of 7 cases) than with a conservative operation (2 of 4 cases). Non-operative management of acute hematoma resulted in radiographic resolution and improvement of hypertension in 3 of 3 patients. Awareness of the clinical features and judicious use of diagnostic modalities enable proper management of subcapsular renal hematomas in most cases.

Endoscopic-guided Versus Fluoroscopic-guided Renal Access for Percutaneous Nephrolithotomy: A Comparative Analysis

OBJECTIVEnTo evaluate the intraoperative outcomes of percutaneous renal access using fluoroscopic-guided access (FGA) vs endoscopic-guided access (EGA).nnnMETHODSnA retrospective record review was conducted of patients undergoing percutaneous nephrolithotomy (PCNL), categorized by the method of achieving renal access. Patients were randomly assigned to 1 of 2 endourologists: 1 practicing EGA and the other practicing FGA. Patient demographics, baseline characteristics, and operative and postoperative outcomes were compared using univariate and multivariate analysis.nnnRESULTSnFrom August 2010 to January 2012, 159 patients underwent PCNL (40% EGA, 60% FGA). No significant difference was observed between groups in age (P = .06), American Society of Anesthesiologists Physical Status Classification (P = .7), number of stones (P = .058), cumulative stone diameter (P = .051), number of calyces involved (P = .82), and stone density (P = .49). Body mass index (BMI) was higher in patients undergoing EGA (P = .013). Patients undergoing EGA had shorter fluoroscopy time (3.2 vs 16.8 minutes, P <.001) and lower access number (1.03 vs 1.22 P = .002). Fluoroscopy time was longer for FGA than for EGA after adjusting for BMI, staghorn stones, and access number (P <.001). No significant difference was noted in change in hemoglobin, blood transfusion rate, operative time, or intraoperative complications between groups. Procedures were aborted due to bleeding more commonly in the FGA (8%) than in the EGA group (0%, P = .02) A secondary procedure for stone management was required in 2 (3.2%) of the EGA group compared with 12 (12.5%) of the FGA group.nnnCONCLUSIONnEGA is safe and effective and leads to decreased fluoroscopy time, decreased need for multiple accesses, and decreased risk of early termination of the procedure or need for secondary procedures.

Patient Decision Making for Asymptomatic Renal Calculi: Balancing Benefit and Risk

OBJECTIVEnTo evaluate which variables affect patients decisions on the management of asymptomatic renal calculi.nnnMATERIALS AND METHODSnWe hypothesized that patients who had experienced greater pain, passed larger or more stones, or passed stones more recently would be more likely to choose surgical intervention (ureteroscopy [URS] or shock wave lithotripsy [ESWL]) instead of observation (OBS). The survey was distributed to 101 patients in our stone clinic. The patients were given a hypothetical scenario of an asymptomatic 8-mm lower pole stone and descriptions for OBS (annual radiography, 40% chance of growth >10 mm within 4 years, 20% chance of passage), ESWL (65% success rate), and URS (90% success rate, with stent placement for 1 week). The patients were also asked whether they would rather defer the decision to their physician.nnnRESULTSnOf the patients, 22.8% chose OBS, 29.7% chose URS, and 47.5% chose ESWL. The patients who had passed larger stones (P = .029) were less likely to choose OBS over surgery. Of the 78 patients who chose intervention, 61.5% preferred ESWL. The patients were more likely to choose URS if they had previously undergone URS (P = .0064) and stent placement (P = .048), and the patients were more likely to choose ESWL if they had a previously undergone ESWL (P = .019). Surgical choice was not affect by size of the largest stone passed (P = .46), date of last passage (P = .080), previous pain intensity (P = .11), previous percutaneous nephrolithotomy (P = .73), or number of stones passed (P = .51). Finally, 56.4% of patients deferred the decision of the treatment approach to the physician.nnnCONCLUSIONnPrevious stone experience and treatment significantly affected treatment choice. Patients rely on their physician to educate them on the alternatives and play an active role in selecting the treatment approach.

Screening Excretory Urography in Patients with Cryptorchidism or Hypospadias: A Survey and Review of the Literature

Hypospadias and cryptorchidism constitute common problems in urology for which the use of routine screening urography has been challenged recently. To assess better current thinking 233 urologists who devote a significant part of their practice to children were surveyed as to the number of procedures performed as well as to the instances when excretory urography was obtained. Of 163 physicians who responded 70 per cent do not favor routine screening urography in cryptorchid patients, while approximately 50 per cent believe that it is worthwhile in hypospadias. In the cryptorchid responses there was a definite decrease in the percentage of physicians obtaining x-rays as the yearly volume of cases increased (50 per cent with less than 10 cases per year and 18 per cent with greater than 20 cases per year), while this relationship was not maintained for hypospadias. A review of the literature correlates well with this survey in that excretory urography is not necessary in cases of cryptorchidism but its value is still debated in cases of hypospadias.

Aortorenal reimplantation in treatment of renovascular hypertension

From 1964 to 1977, 33 patients underwent aortorenal reimplantation as surgical treatment for renovascular hypertension. Over-all results were 13 patients cured (39 per cent), 15 patients improved (46 per cent), and there were 5 failures (15 per cent). The results were equally satisfactory in patients with atherosclerotic or fibrous renal artery disease. Postoperative arterial stenosis or occlusion occurred in 5 patients (15 per cent). Aortorenal reimplantation is an effective method of renal revascularization in properly selected patients, and long-term results are comparable with those of aortorenal bypass.

Systemic Inflammatory Response Syndrome after Percutaneous Nephrolithotomy: A Randomized Single-Blind Clinical Trial Evaluating the Impact of Irrigation Pressure.

PURPOSEnWe evaluated the impact of intraoperative irrigation pressures on the risk of systemic inflammatory response after percutaneous nephrolithotomy.nnnMATERIALS AND METHODSnBetween January 2014 and March 2015, 90 patients with renal stones planned for percutaneous nephrolithotomy were randomized between low (80 mm Hg) and high (200 mm Hg) irrigation pressure. Patient demographics, perioperative outcomes and systemic inflammatory response incidence rates were compared using the chi-square and Wilcoxon signed rank tests.nnnRESULTSnMean patient age, gender, body mass index and other perioperative outcomes were similar in both arms. High pressure irrigation was associated with a higher risk of systemic inflammatory response syndrome (46%) compared to low pressure irrigation (11%, p=0.0002). On multivariate analysis only high irrigation pressure, paraplegia or neurogenic bladder and nonquinolone perioperative medication were predictive of postoperative systemic inflammatory response syndrome.nnnCONCLUSIONSnHigh pressure fluid irrigation fluid increases the risk of postoperative systemic inflammatory response syndrome after percutaneous nephrolithotomy.

Tubeless percutaneous nephrolithotomy: outcomes with expanded indications

INTRODUCTIONnTubeless PCNL has been utilized to shorten hospital stay and improve patient postoperative pain control. Prior studies have excluded those patients with significant bleeding or other complications. Our objective was to evaluate the utility of tubeless PCNL in all patients irrespective of intraoperative outcome.nnnMATERIALS AND METHODSnA retrospective review of the charts of patients who underwent PCNL at our institute was performed. Patients were assigned to one endourologist Who routinely performed tubeless PCNL and to a second endourologist who routinely left a small-bore pigtail nephrostomy. Preoperative demographics operative and postoperative outcomes were compared.nnnRESULTSnOut of 159 patients included, 83 patients had tubeless PCNL while 76 patients had standard PCNL. There was no difference between groups regarding age, gender, ASA score, number, maximum diameter of stones, number of calyces involved, Stone density (HU), laterality and use of preoperative narcotics. While staghorn stones were more common in patients who underwent standard PCNL (p = 0.008). Tubeless patients had less number of access tracts (p ≤ 0.001), shorter hospital stay (1.7 vs. 3.0 days, p = 0.001) when compared to standard PCNL group. Multivariable analysis controlling for confounding factors including staghorn calculi and number of accesses confirmed that tubeless PCNL was associated with shorter hospital stay and less postoperative pain. There was no significant difference in complication rates between the two groups.nnnCONCLUSIONnOur report confirms the previous reports of shorter hospital stay, less pain and analgesia as compared to standard PCNL, and establishes its safety irrespective of bleeding, perforation, extravasation or other intraoperative issues that have previously been utilized as exclusionary criteria for this approach.