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Featured researches published by Marta Sosnowska.


Biosensors and Bioelectronics | 2015

Extended-gate field-effect transistor (EG-FET) with molecularly imprinted polymer (MIP) film for selective inosine determination.

Zofia Iskierko; Marta Sosnowska; Piyush Sindhu Sharma; Tiziana Benincori; Francis D’Souza; Izabela Kamińska; K. Fronc; Krzysztof Noworyta

A novel recognition unit of chemical sensor for selective determination of the inosine, renal disfunction biomarker, was devised and prepared. For that purpose, inosine-templated molecularly imprinted polymer (MIP) film was deposited on an extended-gate field-effect transistor (EG-FET) signal transducing unit. The MIP film was prepared by electrochemical polymerization of bis(bithiophene) derivatives bearing cytosine and boronic acid substituents, in the presence of the inosine template and a thiophene cross-linker. After MIP film deposition, the template was removed, and was confirmed by UV-visible spectroscopy. Subsequently, the film composition was characterized by spectroscopic techniques, and its morphology and thickness were determined by AFM. The finally MIP film-coated extended-gate field-effect transistor (EG-FET) was used for signal transduction. This combination is not widely studied in the literature, despite the fact that it allows for facile integration of electrodeposited MIP film with FET transducer. The linear dynamic concentration range of the chemosensor was 0.5-50 μM with inosine detectability of 0.62 μM. The obtained detectability compares well to the levels of the inosine in body fluids which are in the range 0-2.9 µM for patients with diagnosed diabetic nephropathy, gout or hyperuricemia, and can reach 25 µM in certain cases. The imprinting factor for inosine, determined from piezomicrogravimetric experiments with use of the MIP film-coated quartz crystal resonator, was found to be 5.5. Higher selectivity for inosine with respect to common interferents was also achieved with the present molecularly engineered sensing element. The obtained analytical parameters of the devised chemosensor allow for its use for practical sample measurements.


Biosensors and Bioelectronics | 2016

Potentiometric chemosensor for neopterin, a cancer biomarker, using an electrochemically synthesized molecularly imprinted polymer as the recognition unit.

Piyush Sindhu Sharma; Agnieszka Wojnarowicz; Marta Sosnowska; Tiziana Benincori; Krzysztof Noworyta; Francis D'Souza; Wlodzimierz Kutner

With an established procedure of molecular imprinting, a synthetic polymer receptor for the neopterin cancer biomarker was devised and used as a recognition unit of a potentiometric chemosensor. For that, bis-bithiophene derivatized with cytosine and bithiophene derivatized with boronic acid were used as functional monomers. The open-circuit potential (OCP) based transduction under flow-injection analysis conditions (FIA) determined neopterin in the concentration range of 0.15-2.5mM with the 22 µM limit of detection (LOD) and 7.01(±0.15) mVmM(-1) sensitivity indicating its potential suitability in clinical analysis applications. The molecularly imprinted polymer (MIP) film showed an appreciable apparent imprinting factor of ~6. The chemosensor successfully discriminated the interferences including the 6-biopterin and pterin structural analogs of neopterin as well as glucose and creatinine. Moreover, it determined neopterin in synthetic serum samples.


Biosensors and Bioelectronics | 2017

Direct determination of small RNAs using a biotinylated polythiophene impedimetric genosensor

Diego Voccia; Marta Sosnowska; Francesca Bettazzi; Giuseppina Roscigno; Emiliano Fratini; Vittorio de Franciscis; Gerolama Condorelli; Raghu Chitta; Francis D’Souza; Wlodzimierz Kutner; Ilaria Palchetti

Herein, direct determination of small RNAs is described using a functional-polymer modified genosensor. The analytical strategy adopted involves deposition by electropolymerization of biotinylated polythiophene films on the surface of miniaturized, disposable, gold screen-printed electrodes, followed by the layer-by-layer deposition of streptavidin, and then biotynilated capture probes. A small RNA (miR-221) target was determined via the impedimetric measurement of the hybridization event in a label-free and PCR-free approach. Under optimized conditions, the limit of detection (LOD) was 0.7 pM miR-221 (15% RSD). The genosensor was applied for determination of miR-221 in total RNA extracted from human lung and breast cancer cell lines, discriminating between the cancer-positive and -negative cells, without any amplification step, in less than 2h.


Progress in Polymer Science | 2015

Functionalized polythiophenes: Recognition materials for chemosensors and biosensors of superior sensitivity, selectivity, and detectability

Tan-Phat Huynh; Piyush Sindhu Sharma; Marta Sosnowska; Francis D'Souza; Wlodzimierz Kutner


Biosensors and Bioelectronics | 2015

Selective electrochemical sensing of human serum albumin by semi-covalent molecular imprinting.

Maciej Cieplak; Katarzyna Szwabinska; Marta Sosnowska; Bikram K.C. Chandra; Paweł Borowicz; Krzysztof Noworyta; Francis D’Souza; Wlodzimierz Kutner


Analytical Chemistry | 2013

Simultaneous chronoamperometry and piezoelectric microgravimetry determination of nitroaromatic explosives using molecularly imprinted thiophene polymers.

Tan-Phat Huynh; Marta Sosnowska; Janusz W. Sobczak; Chandra B. Kc; Vladimir N. Nesterov; Francis D’Souza; Wlodzimierz Kutner


Biosensors and Bioelectronics | 2015

Nicotine molecularly imprinted polymer: synergy of coordination and hydrogen bonding.

Tan-Phat Huynh; Chandra Bikram K C; Marta Sosnowska; Janusz W. Sobczak; Vladimir N. Nesterov; Francis D'Souza; Wlodzimierz Kutner


Biosensors and Bioelectronics | 2015

Cytosine derivatized bis(2,2′-bithienyl)methane molecularly imprinted polymer for selective recognition of 6-thioguanine, an antitumor drug

Tan Phat Huynh; Agnieszka Wojnarowicz; Marta Sosnowska; Simchac Srebnik; Tiziana Benincori; Francesco Sannicolò; Francis D'Souza; Wlodzimierz Kutner


Analytical Chemistry | 2013

Piezomicrogravimetric and Impedimetric Oligonucleotide Biosensors Using Conducting Polymers of Biotinylated Bis(2,2′-bithien-5-yl)methane as Recognition Units

Marta Sosnowska; Piotr Pieta; Piyush Sindhu Sharma; Raghu Chitta; Chandra B. Kc; Venugopal Bandi; Francis D’Souza; Wlodzimierz Kutner


Journal of Materials Chemistry B | 2016

An electropolymerized molecularly imprinted polymer for selective carnosine sensing with impedimetric capacity

Agnieszka Wojnarowicz; Piyush Sindhu Sharma; Marta Sosnowska; Wojciech Lisowski; Tan-Phat Huynh; Maria Pszona; Paweł Borowicz; Francis D'Souza; Wlodzimierz Kutner

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Wlodzimierz Kutner

Cardinal Stefan Wyszyński University in Warsaw

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Tan-Phat Huynh

Polish Academy of Sciences

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Francis D'Souza

University of North Texas

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Janusz W. Sobczak

Polish Academy of Sciences

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