Martin Sénéchal

Dynapenic Abdominal Obesity and Metabolic Risk Factors in Adults 50 Years of Age and Older

Objectives: To investigate the additive effect of dynapenia and abdominal obesity on metabolic risk factors in older adults. Method: A total of 3,007 men and women from the National Health and Nutrition Examination Survey (NHANES) study were categorized as follows: (a) non-dynapenic/non-abdominally obese (N-DYN/N-AO), (b) dynapenic/non-abdominally obese (DYN/N-AO), (c) non-dynapenic/abdominally obese (N-DYN/AO), (d) dynapenic/ abdominally obese (DYN/AO) based on waist circumference (WC) and leg muscle strength tertiles. Dependent variables were lipids, glucose, blood pressure, and other chronic conditions. Results: The DYN/AO group had lower plasma HDL-chol and higher triglyceride and glucose levels than N-DYN/N-AO and DYN/N-AO groups (all p ≤ .01). Higher plasma triglyceride was observed in the DYN/AO group compared with N-DYN/AO group (p ≤ .01). The odds of having metabolic syndrome, cardiovascular diseases, and type II diabetes were higher in DYN/AO compared with DYN/N-AO and N-DYN/N-AO. Conclusion: DYN/AO older adults might be at greater risk of metabolic alterations than those displaying dynapenia alone or those with neither abdominal obesity nor dynapenia.

EFFECTS OF ANTIOXIDANT SUPPLEMENTS COMBINED WITH RESISTANCE EXERCISE ON GAINS IN FAT‐FREE MASS IN HEALTHY ELDERLY SUBJECTS: A PILOT STUDY

Conflict of Interest: The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any other kind of personal conflicts with this letter. Author Contributions: Marc-Alexander Ohlow: concept and design, acquisition of data, analysis and interpretation of data, drafting of the letter, final approval of the version to be published. Maria-Anna Secknus, Hubertus von Korn, Andreas Wagner, Jiangtao Yu, and Bernward Lauer: analysis and interpretation of data, revising of the letter, final approval of the version to be published. Sponsor’s Role: None.

Exercise Training and Habitual Physical Activity A Randomized Controlled Trial

BACKGROUND Exercise training reduces adiposity and risk of cardiovascular disease. However, the combined effects of habitual free-living physical activity and aerobic training on waist circumference, weight, fitness, and blood pressure in postmenopausal women are unknown. PURPOSE To evaluate the effects of habitual physical activity levels during aerobic training on weight, waist circumference, fitness, and blood pressure. DESIGN Secondary analysis of an RCT. Original data collected April 2001 to June 2005 and analyzed in 2012. SETTING/PARTICIPANTS Postmenopausal women in a supervised exercise trial. INTERVENTION Women (n=325) were randomized to 4, 8, or 12 kcal/kg per week of aerobic training or a control group for 6 months. All outcome measures were collected at baseline and follow-up. Changes in dependent variables within each training group were evaluated across tertiles of pedometer-determined habitual physical activity outside exercise training sessions. MAIN OUTCOME MEASURES Changes in waist circumference and weight. RESULTS Reductions in waist circumference were significantly greater with higher steps/day accumulated outside exercise training compared to lower levels in the 4 (high: -4.8 cm vs low: -1.4 cm, p=0.03); 8 (high: -4.2 cm vs low: -0.4 cm, p=0.03), and 12 kcal/kg per week groups (high: -4.1 cm vs low: -0.7 cm, p=0.05). For all groups, p-trend≤0.03. A trend was observed for greater weight reduction with higher steps/day in the 4 kcal/kg per week group (p-trend=0.04) but not for the other exercise doses. No effects were observed for blood pressure or fitness measures (all p>0.05). CONCLUSIONS In postmenopausal women, higher habitual physical activity while participating in aerobic training was associated with greater reductions in central adiposity, and was supportive of weight loss compared to lower levels.

Effects of rapid or slow weight loss on body composition and metabolic risk factors in obese postmenopausal women. A pilot study.

To compare the effect of rapid or slow weight loss (WL) on body composition and metabolic risk factors following a caloric restriction. Ten obese, postmenopausal women were matched for total body WL. Dependent variables were: body composition, lipid profile and blood pressure. Both groups decreased obesity measures (all P≤0.05) while lean body mass decreased in the rapid WL group (P≤0.05). Significant improvements in fasting triglyceride level and diastolic blood pressure were observed only in the slow WL group. A slower WL seems to be more beneficial to improve body composition as well as metabolic risk factors in postmenopausal women.

Weight gain since menopause and its associations with weight loss maintenance in obese postmenopausal women.

Objective To examine the association between weight gain since menopause and weight regain after a weight loss program. Methods Participants were 19 obese women who participated in a 15-week weight loss program and a 12-month follow-up. Main outcomes were: body composition, resting metabolic rate, energy intake, energy expenditure, and weight regain at follow-up. Results All body composition measures significantly decreased after intervention (all P ≤ 0.01) while all measures of fatness increased significantly after the 12-month follow-up (P ≤ 0.01). Body weight gain since menopause was associated with body weight regain (r = 0.65; P = 0.003) after follow-up even after adjustment for confounders. Conclusion Weight gain since menopause is associated with body weight regain following the weight loss program. Therefore, weight gain since menopause should be considered as a factor influencing weight loss maintenance in older women.

Changes in Objective and Self-Reported Measures of Physical Capacity After an Intervention in Obese Older Women

The aim of this study was to determine if objective and self-reported measures of physical capacity are two equivalent methods to detect changes following an intervention in obese older women. 36 obese women aged between 55 and 75 years participated in a 3-month study with the aim of improving physical capacity by caloric restriction and/or resistance training. Physical capacity was measured objectively with 10 different tests and self-reported with the SF-36 physical functioning score (SF-36 PF score). Then the performance-to-objective tests were computed using quartiles to provide a baseline global physical capacity score. The mean percentage of change of the 10 tests as well as the SF-36 PF score were also calculated after the study. Body composition was measured by dual-energy X-ray (DXA) absorptiometry. The baseline global physical capacity score and the SF-36 PF score were significantly correlated at baseline (r = 0.43; P < 0.01). Eight out of the 10 objective tests of physical capacity improved after the intervention, while no improvement was observed for the SF-36 PF score. On average, percentage of change in physical capacity was 4.1 ± 5.9% for the SF-36 PF score and 11.1 ± 2.9% for the objective measures. However, no significant correlation was observed between percentage of changes between the two approaches after the intervention (r = 0.32; P = 0.07). Based on these results, the method used to quantify physical capacity after an intervention may have major implications on the outcomes. The methods used should be carefully analyzed in regard to the objective of the study.

Interindividual variations in resting metabolic rate during weight loss in obese postmenopausal women: A pilot study

The objective of the study was to examine if decreases in resting metabolic rate (RMR) take place early in the weight loss process and if they remain throughout the duration of the weight loss intervention. Twenty obese postmenopausal women (61.8 +/- 5.9 years) participated in a 15-week weight loss program. After the fifth week, subjects were characterized as having an increased (>5%) or a decreased (<5%) RMR based on baseline values. Afterward, they were followed for an additional 10 weeks. Outcome measures were as follows: fat mass ([FM] total, trunk), lean body mass (total, trunk), RMR, resting heart rate (RHR), and physical activity level. After 5 weeks, significant decreases were observed for lean body mass, FM, and RHR (P < .05), whereas no overall changes in physical activity level and RMR were observed. However, on an individual basis, large variations in RMR were observed (ranging from -320 to +330 kcal/d). Analyses showed that subjects characterized as either having an increased or a decreased RMR after the fifth week maintained these adaptations at the end of intervention. Finally, subjects displaying a decreased RMR during weight loss had a significantly higher RMR and lower FM accumulations at baseline (total and trunk) compared with those with an increased RMR. Interindividual variations in RMR took place early in the weight loss process and were maintained over the duration of the weight loss program in our cohort of obese postmenopausal women. Baseline RMR, changes in RHR, and FM accumulations (total and trunk) seem to be important factors to consider when studying the effects of weight loss on RMR.

Effects of Caloric Restriction with or without Resistance Training in Dynapenic-Overweight and Obese Menopausal Women: A MONET Study.

OBJECTIVE The dynapenic (DYN)-obese phenotype is associated with an impaired metabolic profile. However, there is a lack of evidences regarding the effect of lifestyle interventions on the metabolic profile of individual with dynapenic phenotype. The objective was to investigate the impact of caloric restriction (CR) with or without resistance training (RT) on body composition, metabolic profile and muscle strength in DYN and non-dynapenic (NDYN) overweight and obese menopausal women. DESIGN 109 obese menopausal women (age 57.9 ± 9.0 yrs; BMI 32.1 ± 4.6 kg/m2) were randomized to a 6-month CR intervention with or without a RT program. Participants were categorized as DYN or NDYN based on the lowest tertile of relative muscle strength in our cohort (< 4.86 kg/BMI). MEASUREMENTS Body composition was measured by DXA, body fat distribution by CT scan, glucose homeostasis at fasting state and during an euglycemic-hyperinsulinemic clamp, fasting lipids, resting blood pressure, fasting inflammation markers and maximal muscle strength. RESULTS No difference was observed between groups at baseline for body composition and the metabolic profile. Overall, a treatment effect was observed for all variables of body composition and some variables of the metabolic profile (fasting insulin, glucose disposal, triglyceride levels, triglycerides/HDL-Chol ratio and resting diastolic blood pressure) (P between 0.05 and 0.001). No Group X Treatment interaction was observed for variables of body composition and the metabolic profile. However, an interaction was observed for muscle strength; which significantly improved more in the CR+RT NDYN group (all P ≤ 0.05). CONCLUSIONS In the present study, dynapenia was not associated with a worse metabolic profile at baseline in overweight and obese menopausal women. DYN and NDYN menopausal women showed similar cardiometabolic benefit from CR or CR+RT interventions. However, our results showed that the addition of RT to CR was more effective in improving maximal strength in DYN and NDYN obese menopausal women.

The Impact of Exercise Intensity Feed-back via Technology for Children during Active Play (Preprint)

Background Most children do not engage in enough exercise at the recommended intensity. Using technological devices may increase the time children spend at greater intensities while exercising. Objective This study aimed to determine if children who are receiving instant feedback on their exercise intensity using technology would spend more time in moderate-vigorous intensity (≥70% of maximum capacity) during active play sessions. It also aimed to explore if the children’s physical characteristics were associated with the average percentage of maximal heart rate (HR) reached during sessions. Methods Participants were asked to wear a HR monitor, attached around their chest, for 4 sessions out of the 15 sessions offered. Twenty children aged 5 to 11 years received feedback for 2 random sessions. When receiving feedback, color-coded intensity based on HR was projected onto a wall. Green corresponded to moderate intensity (≥70% of max HR) and red corresponded to a HR below moderate intensity. Age, anthropometric measures, muscle strength, body composition, physical activity level, and fitness level were measured. Results The average percentage of maximal HR during a session was similar whether feedback was provided (70.7%, SD 6.4%) or not (71.1%, SD 4.1%) with P=.93. No personal characteristics were associated with the average intensity recorded during the exercise sessions. Conclusions Receiving instant exercise intensity feedback is not associated with a higher proportion of time spent at moderate intensity or above in children aged 5 to 11 years when involved in an active play program. Personal characteristics are not associated with the intensity recorded when participating in an active play program.