Mary Lohman
University of Michigan
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Neurology | 1995
Sid Gilman; R. T. St. Laurent; Robert A. Koeppe; Larry Junck; Karen J. Kluin; Mary Lohman
Objective In sporadic cases of olivopontocerebellar atrophy (OPCA), to determine whether local cerebral blood flow (ICBF) is reduced, whether lCBF is coupled to local cerebral metabolic rate for glucose (lCMRglc), and whether lCBF measurements are potentially useful in diagnosing OPCA. Design Positron emission tomography was used with [15O]H2O to measure lCBF and with [18F]fluorodeoxyglucose to measure lCMRglc in 17 patients with OPCA and 21 normal control subjects. Results In OPCA patients, lCBF was significantly decreased in the cerebellum, but not in the cerebral cortex, basal ganglia, thalamus, or brainstem. In the same patients, lCMRglc was significantly decreased in the cerebellum and brainstem, where the largest changes were observed, and also in the cerebral cortex, basal ganglia, and thalamus. The ratio of lCBF to lCMRglc, an indicator of the coupling of blood flow to metabolism, was similar in OPCA patients and normal subjects for all regions except the brainstem, where the ratio was marginally decreased in OPCA patients. Using logistic discriminant analysis to assess the ability of lCBF and lCMRglc to differentiate OPCA patients from normal subjects, we found the cross-validated sensitivity of absolute lCMRglc as a predictor of OPCA was 82% with a corresponding specificity of 71%; the sensitivity of absolute lCBF was 71% and the specificity 76%. Conclusions In sporadic cases of OPCA, lCBF is reduced in the cerebellum, CBF remains coupled to lCMRglc, and the lCBF pattern is a useful predictor of the diagnosis.
Neurology | 1996
Sid Gilman; Roy T. St. Laurent; Robert A. Koeppe; Larry Junck; Karen J. Kluin; Mary Lohman
Reply from the Authors: We thank Dr. Botez et al. for calling their paper to our attention. We overlooked the fact that this report describes SPECT studies of patients with OPCA because of its title, which refers to cerebello-cerebral diaschisis. In the article, Dr. Botez et al. report SPECT …
Annals of Neurology | 1996
Sid Gilman; Anders A. F. Sima; Larry Junck; Karen J. Kluin; Robert A. Koeppe; Mary Lohman; Roderick J. A. Little
Annals of Neurology | 1996
Sid Gilman; Robert A. Koeppe; Kenneth M. Adams; Douglas Johnson-Greene; Larry Junck; Karen J. Kluin; James A. Brunberg; Susan Martorello; Mary Lohman
Annals of Neurology | 1994
Sid Gilman; Robert A. Koeppe; Larry Junck; Karen J. Kluin; Mary Lohman; Roy T. St. Laurent
Annals of Neurology | 1996
Sid Gilman; Kirk A. Frey; Robert A. Koeppe; Larry Junck; Roderick J. A. Little; Thierry Vander Borght; Mary Lohman; Susan Martorello; Lihsueh C. Lee; Douglas M. Jewett; Michael R. Kilbourn
Neuropsychology (journal) | 1995
Kenneth M. Adams; Sid Gilman; Robert A. Koeppe; Karen J. Kluin; Larry Junck; Mary Lohman; Douglas Johnson-Greene; Stanley Berent; Duane Dede; Phillip Kroll
JAMA Neurology | 1996
Karen J. Kluin; Sid Gilman; Mary Lohman; Larry Junck
Annals of Neurology | 1995
Sid Gilman; Robert A. Koeppe; Larry Junck; Karen J. Kluin; Mary Lohman; Roy T. St. Laurent
Advances in Neurology | 1996
Sid Gilman; Robert A. Koeppe; Larry Junck; Karen J. Kluin; Mary Lohman; R. T. St. Laurent