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Masaaki Nagasawa

Hokkaido University

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Featured researches published by Masaaki Nagasawa.

Tetrahedron Letters | 1997

Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 8. Synthesis of the lactone part (C1C36) via horner-emmons coupling between C1C15 and C16C36 fragments and Yamaguchi lactonization

Kiyoshi Horita; Masaaki Nagasawa; S. Hachiya; Youji Sakurai; Tatsuya Yamazaki; Jun'ichi Uenishi; Osamu Yonemitsu

Abstract The lactone part ( 2 ) of halichondrin B ( 1 ) was synthesized by Yamaguchi macrolactonization of the seco-acid ( 3 ), which was synthesized via coupling of C1C15( 4 ) with C16C36 ( 5 ), prepared through stereoselective construction of the E ring starting from C16C26 ( 7 ) and C27C36 ( 8 ).

Synlett | 1994

Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. III: Synthesis of C27-C36 subunit via completely stereoselective C-glycosylation to the F ring

Kiyoshi Horita; Youji Sakurai; Masaaki Nagasawa; S. Hachiya; Osamu Yonemitsu

Synlett | 1994

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 1. Stereoselective Synthesis of the C1-C13 Fragment via Construction of the B and A Rings by Kinetically and thermodynamically Controlled Intramolecular Michael Reactions.

Kiyoshi Horita; S. Hachiya; Masaaki Nagasawa; Masataka Hikota; Osamu Yonemitsu

Heterocycles | 1996

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge 5. A Highly Concise and Efficient Synthesis of the C37~C54 Tricyclic JKL-Ring Part

Kiyoshi Horita; S. Hachiya; Kazuhito Ogihara; Yutaka Yoshida; Masaaki Nagasawa; Osamu Yonemitsu

Synlett | 1994

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 2. Efficient Synthesis of C16-C26 Fragments via Construction of the D Ring by a Highly Stereocontrolled Iodoetherification

Kiyoshi Horita; Masaaki Nagasawa; S. Hachiya; Osamu Yonemitsu

Biological & Pharmaceutical Bulletin | 1994

4-Acylaminophenol Derivatives as Novel Lipoxygenase Inhibitors : Synthesis and Inhibitory Effect on 5-Lipoxygenase and Leukotriene B4 Production

Matsuo Kikuchi; Yoshimasa Hashimura; Kei Tsuzurahara; Masaaki Nagasawa; Hirozumi Inoue; Tomoyasu Taniguchi; Tomofumi Uchida

Chemical & Pharmaceutical Bulletin | 1992

A New Synthetic Route to 1, 5-Benzothiazepines. Synthesis of Derivatives of Diltiazem

Tsunehiro Harada; Masamichi Morimoto; Masaaki Nagasawa; Norio Takamura; Hirozumi Inoue; Tokuro Oh-Ishi; Mikio Takeda

Synlett | 1994

Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. IV: Synthesis of the C37-C54 subunit via stereoselective construction of three consecutive J, K, and L rings

Kiyoshi Horita; Youji Sakurai; Masaaki Nagasawa; K. Maeno; S. Hachiya; Osamu Yonemitsu

Chemical & Pharmaceutical Bulletin | 1994

Large laboratory scale synthesis of (2S,3S)-2-(4-methoxybenzyloxy)-3,4-O-(3-pentylidene)-1,3,4-butantriol, a versatile chiral building block in natural product synthesis

Kiyoshi Horita; Youji Sakurai; S. Hachiya; Masaaki Nagasawa; Osamu Yonemitsu

ChemInform | 2010

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. Part 1. Stereoselective Synthesis of the C1-C13 Fragment via Construction of the B and A Rings by Kinetically and Thermodynamically C

Kiyoshi Horita; S. Hachiya; Masaaki Nagasawa; M. Hikota; Osamu Yonemitsu

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Kiyoshi Horita

Hokkaido University

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Osamu Yonemitsu

Hokkaido University

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S. Hachiya

Hokkaido University

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Youji Sakurai

Hokkaido University

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Hirozumi Inoue

National Institutes of Health

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Norio Takamura

University of Tokyo

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Tsunehiro Harada

Kanazawa University

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Jun'ichi Uenishi

Okayama University of Science

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K. Maeno

Hokkaido University

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Kazuhito Ogihara

Hokkaido University

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