Masahiko Kusunose

Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats

The anti‐allergic activity of Eriobotrya japonica seeds extract (ESE) was investigated. Oral administration of ESE dramatically inhibited ear swelling due to allergic contact dermatitis caused by repeated application of two antigens, 4‐ethoxymethylene‐2‐phenyl‐2‐oxazolin‐5‐one (oxazolone) and dinitrofluorobenzene (DNFB), respectively. The increase of histamine content in inflamed ear tissue induced by oxazolone and DNFB was significantly antagonized by orally administered ESE. Eosinophil peroxidase and myeloperoxidase activity in both models was suppressed by orally administered ESE. Tumour necrosis factor‐α in the inflamed region caused by repeated application of DNFB was also significantly suppressed. The findings suggest that ESE may be effective for treating allergic contact dermatitis.

Animal studies supporting the inhibition of mast cell activation by Eriobotrya japonica seed extract

Objectives The potent antioxidant activity of Eriobotrya japonica seed extract (ESE) and its usefulness in the prevention and treatment of various disorders has been reported previously. Its antioxidant activity associated with β‐sitosterol and polyphenols contained in the extract was also validated. In this study, anti‐allergic activity of Eriobotrya japonica seed extract was investigated.