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Publication
Featured researches published by Masahiko Uchida.
Bioorganic & Medicinal Chemistry Letters | 2008
Masahiko Uchida; Kosuke Okazaki; Harunobu Mukaiyama; Hidetoshi Isawa; Hiroaki Kobayashi; Hiroaki Shiohara; Hideyuki Muranaka; Yuichiro Kai; Norihiko Kikuchi; Hideki Takeuchi; Kenji Yokoyama; Eiichi Tsuji; Tomonaga Ozawa; Yuji Hoyano; Takashi Koizumi; Keiko Misawa; Kiyoto Hara; Shigeru Nakano; Yasuoki Murakami; Hiroaki Okuno
A series of novel and potent 3-amidinophenylsulfonamide derivatives of factor Xa inhibitors were designed and synthesized using an amidoxime prodrug strategy. We focused on systemic clearance of parent compounds in rats, and performed in vivo pharmacokinetic screening. Incorporation of a carboxymethoxy group markedly improved systemic clearance (compound 43), and the related amidoxime 44 showed sufficient prodrug conversion. Compound 45, the double prodrug of 43, exhibited practicable bioavailability after oral administration in rats. Among the various compounds under investigation, KFA-1982 was selected for clinical development.
Archive | 1998
Satoshi Akahane; Masahiko Uchida; Hideotoshi Isawa; Norihiko Kikuchi; Tomonaga Ozawa; Hiroaki Kobayashi; Yuichiro Kai; Kenji Akahane
Archive | 2001
Kosuke Okazaki; Masahiko Uchida; Harunobu Mukaiyama; Hiroaki Kobayashi; Yuichiro Kai; Hideki Takeuchi; Kenji Yokoyama; Yoshihiro Terao; Yuji Hoyano; Hiroaki Shiohara; Norihiko Kikuchi
Archive | 2002
Masahiko Uchida; Hiroaki Kobayashi; Yuichiro Kai; Kenji Yokoyama; Yoshihiro Terao; Hideyuki Muranaka
Archive | 2000
Satoshi Akahane; Masahiko Uchida; Hidetoshi Isawa; Norihiko Kikuchi; Yuichiro Kai; Kiyoto Hara; Toshiki Honma
Archive | 2002
Kosuke Okazaki; Masahiko Uchida; Hiroaki Kobayashi; Yuichiro Kai; Hideki Takeuchi; Kenji Yokoyama; Yoshihiro Terao; Ritsu Suzuki
Journal of Toxicological Sciences | 2003
Kiyoto Hara; Toshiki Honma; Akane Matsuzawa; Atsushi Matsuzawa; Masahiko Uchida; Takashi Koizumi; Satoshi Akahane; Masami Kojima
Journal of Health Science | 2003
Kiyoto Hara; Toshiki Honma; Yuji Hoyano; Takashi Koizumi; Masahiko Uchida; Satoshi Akahane; Masami Kojima; Masuo Akahane
Archive | 2002
Kosuke Okazaki; Masahiko Uchida; Hiroaki Kobayashi; Yuichiro Kai; Hideki Takeuchi; Kenji Yokoyama; Yoshihiro Terao; Ritsu Suzuki
Archive | 2001
Kosuke Okazaki; Masahiko Uchida; Harunobu Mukaiyama; Hiroaki Kobayashi; Yuichiro Kai; Hideki Takeuchi; Kenji Yokoyama; Yoshihiro Terao; Yuji Hoyano; Hiroaki Shiohara; Norihiko Kikuchi
