Masanao Yamamoto
Hitachi
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Hypertension Research | 2014
Kazunori Toyoda; Masahiro Yasaka; Shinichiro Uchiyama; Kazunori Iwade; Yukihiro Koretsune; Ken Nagata; Tomohiro Sakamoto; Takehiko Nagao; Masahiro Yamamoto; Jun Gotoh; Jun Takahashi; Kazuo Minematsu; Koichi Toyoda; A Tokunaga; A Takebayashi; M Yasaka; Masanao Yamamoto; Tetsuhiko Nagao; T Sakamoto; K Iwade; Keiichi Nagata; J Gotoh; Y Koretsune; Juro Takahashi; T Ochi; T Umemoto; T Nakazato; Mie Shimizu; M Okamoto; Hisanori Shinohara
The CHADS2 and CHA2DS2-VASc scores, that is, ischemic stroke risk indices for patients having atrial fibrillation (AF), may also be useful as bleeding risk indices. Japanese patients with AF, who routinely took oral antithrombotic agents were enrolled from a prospective, multicenter study. The CHADS2 and CHA2DS2-VASc scores were assessed based on information at entry. Scores of 0, 1 and ⩾2 were defined as the low, intermediate and high ischemic risk categories, respectively, for each index. Of 1221 patients, 873 took warfarin, 114 took antiplatelet agents and 234 took both. The annual incidence of ischemic stroke was 0.76% in the low-risk category, 1.46% in the intermediate-risk category and 2.90% in the high-risk category by CHADS2 scores, and 1.44, 0.42 and 2.50%, respectively, by CHA2DS2-VASc scores. The annual incidence of major bleeding in each category was 1.52, 2.19 and 2.25% by CHADS2, and 1.44, 1.69 and 2.24% by CHA2DS2-VASc. After multivariate adjustment, the CHADS2 was associated with ischemia (odds ratio 1.76, 95% confidence interval 1.03–3.38 per 1−category increase) and the CHA2DS2-VASc tended to be associated with ischemia (2.18, 0.89–8.43). On the other hand, associations of the indices with bleeding were weak. In conclusion, bleeding risk increased gradually as the CHADS2 and CHA2DS2-VASc scores increased in Japanese antithrombotic users, although the statistical impact was rather weak compared with their predictive power for ischemic stroke.
Archive | 1986
Eisuke Inoue; Yasuhiko Nonaka; Masanao Yamamoto
Archive | 2000
Hideo Sato; Yoshiro Mikami; Makoto Tsumura; Genshiro Kawachi; Tatsuya Ohkubo; Shigeo Shimomura; Kenkichi Suzuki; Masanao Yamamoto
Archive | 1987
Yukio Takasaki; Tatsuo Makishima; Kazutaka Tsuji; Tadaaki Hirai; Eisuke Inoue; Yasuhiko Nonaka; Naohiro Goto; Masanao Yamamoto; Keiichi Shidara; Kenkichi Tanioka; Takashi Yamashita; Tatsuro Kawamura; Eikyuu Hiruma; Shirou Suzuki; Masaaki Aiba
Archive | 2003
Jun Gotoh; Katsutoshi Saito; Makoto Ohkura; Yukio Takasaki; Masanao Yamamoto
Archive | 2003
Jun Goto; Yuichi Harano; Toshiteru Kaneko; Masanao Yamamoto; 雄一 原野; 昌直 山本; 順 後藤; 寿輝 金子
Archive | 1989
Masanao Yamamoto; Takaaki Unnai; Shigeru Ehata; Tadaaki Hirai; Kenji Sameshima; Eikiyu Hiruma; Shirou Suzuki; Kenkichi Tanioka; Junichi Yamazaki; Keiichi Shidara
Archive | 2005
Yuichi Harano; Jun Gotoh; Toshiki Kaneko; Masanao Yamamoto
Archive | 2005
Yuichi Harano; Jun Gotoh; Toshiki Kaneko; Masanao Yamamoto
Archive | 2003
Jun Gotoh; Katsutoshi Saito; Makoto Ohkura; Yukio Takasaki; Masanao Yamamoto