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Dive into the research topics where Masayoshi Yamaoka is active.

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Featured researches published by Masayoshi Yamaoka.


The Journal of Antibiotics | 1978

NEW CEPHALOSPORINS WITH 7-ACYL GROUPS DERIVED FROM β-KETOACIDS

Mitsuo Numata; Masayoshi Yamaoka; Isao Minamida; Masaaki Kuritani; Yoshio Imashiro

The synthesis and antimicrobial profile of a series of 7-(beta-ketoacylamino)cephalosporins (1) bearing an acetoxymethyl or a heterocyclichiomethyl group at the 3-position are described. Of this series, 3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-7-(3-oxobutyrylamino)ceph-3-em-4-carboxylic acid (11) showed moderate antibacterial activities in in vitro and in vivo tests.


The Journal of Antibiotics | 1992

Studies on condensed-heterocyclic azolium cephalosporins. IV. Synthesis and antibacterial activity of 7 beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)- alkoxyiminoacetamido]-3-(condensed-heterocyclic azolium)methyl cephalosporins including SCE-2787.

Akio Miyake; Yoshinobu Yoshimura; Masayoshi Yamaoka; Tatsuo Nishimura; Naoto Hashimoto; Akira Imada


The Journal of Antibiotics | 1987

ORALLY ACTIVE 1-(CYCLOHEXYLOXYCARBONYLOXY)ALKYL ESTER PRODRUGS OF CEFOTIAM

Tatsuo Nishimura; Yoshinobu Yoshimura; Akio Miyake; Masayoshi Yamaoka; Kunio Takanohashi; Naoru Hamaguchi; Shin-Ichiro Hirai; Takatsuka Yashiki; Mitsuo Numata


The Journal of Antibiotics | 1978

A new cephalosporin. SCE-963: 7-[2-(2-aminothiazol-4-yl)-acetamido]-3-[[[1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl]-thio]methyl]ceph-3-em-4-carboxylic acid. Chemistry and structure-activity relationships.

Mitsuo Numata; Isao Minamida; Masayoshi Yamaoka; Mitsuru Shiraishi; Toshio Miyawaki; Hiroshi Akimoto; Kenzo Naito; Makoto Kida


Archive | 1974

7-Alpha-(2-aminothiazole)-acetamido-cephalosporins

Mitsuo Numata; Isao Minamida; Masayoshi Yamaoka; Mitsuru Shiraishi; Toshio Miyawaki


Archive | 1981

2-Oxoazetidine derivatives and production thereof

Mitsuo Numata; Masayoshi Yamaoka; Tatsuo Nishimura; Norichika Matsumoto


Synthesis | 2003

A convenient synthesis of 4(5)-alkylacyl-1H-imidazoles from 4(5)-imidazolecarboxaldehyde

Jun-ichi Kawakami; Kazuhiro Kimura; Masayoshi Yamaoka


Chemical & Pharmaceutical Bulletin | 1977

Synthesis of New Cephalosporins with Potent Antibacterial Activities

Mitsuo Numata; Isao Minamida; Susumu Tsushima; Tatsuo Nishimura; Masayoshi Yamaoka; Norichika Matsumoto


Tetrahedron Letters | 1972

Novel transformations of penicillins into 2-azetidinones with diazo- and azido-compounds and a novel synthesis of desacetoxycephalosporin

Mitsuo Numata; Yoshio Imashiro; Isao Minamida; Masayoshi Yamaoka


The Journal of Antibiotics | 1991

STUDIES ON CONDENSED-HETEROCYCLIC AZOLIUM CEPHALOSPORINS

Yoshinobu Yoshimura; Akio Miyake; Tatsuo Nishimura; Tatsuhiko Kawai; Masayoshi Yamaoka

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Mitsuo Numata

Takeda Pharmaceutical Company

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Isao Minamida

Takeda Pharmaceutical Company

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Toshio Miyawaki

Takeda Pharmaceutical Company

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Yoshio Imashiro

Takeda Pharmaceutical Company

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Tatsuo Nishimura

Takeda Pharmaceutical Company

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Akio Miyake

Takeda Pharmaceutical Company

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Shinji Terao

Takeda Pharmaceutical Company

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Yoshinobu Yoshimura

Takeda Pharmaceutical Company

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Naoki Tarui

Takeda Pharmaceutical Company

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