Masoumeh Ghayouri

Neuroendocrine Neoplasms of the Colon and Rectum

Neuroendocrine neoplasms of the colon and rectum are derived from the same stem cell which gives rise to glandular cells and other cells lining the epithelium. Neuroendocrine carcinomas are more common in the colon, whereas neuroendocrine tumors are more common in the rectum. In the colon neuroendocrine carcinomas can be seen mixed with other types of tumors including adenocarcinomas. These tumors are mainly nonfunctional, but the neuroendocrine tumors in the cecum and right colon which composed of EC cells can be functional and in rare cases can cause carcinoid syndrome. These neoplasms share some of the molecular changes that are seen in these neoplasms in other parts of the GI system.

Thirty-five-year-old woman with signet ring cell gastric carcinoma secondary to the chernobyl nuclear accident: a case report.

The 1986 Chernobyl nuclear accident resulted in radiation exposures throughout much of Europe, with the highest exposures within the city of Pripyat, Ukraine, where the accident occurred. We report a woman who was exposed to the Chernobyl accident at age 13. Beginning in her early thirties, she experienced several years of upper abdominal pain that became progressively more severe. At age 35, she underwent upper endoscopy and gastric biopsy. Histological examination revealed a signet ring cell (SRC) gastric carcinoma. The tumor was discovered at an advanced stage and proved unresectable. She died 3 months following her diagnosis. The mean age for SRC gastric carcinoma diagnosis is about 62 years; the median survival following diagnosis is 13 months. The early appearance and aggressive clinical course of this malignancy in relation to the Chernobyl nuclear accident is discussed.

Primary Uterine Cervix Schwannoma: A Case Report and Review of the Literature

Schwannoma (neurilemmoma) is a benign peripheral nerve sheath tumor that occurs in a wide variety of locations; however, its finding in the uterine cervix is extremely rare. We report a case of an incidental primary benign cervical schwannoma in a 48-year-old woman. In the English literature, a few cases of primary schwannoma of the cervix have been reported, which include seven cases of primary malignant cervical schwannoma and only two that are benign. These cases are reviewed in the following discussion.

Expression of Her-2/neu in extrahepatic cholangiocarcinoma

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Molecular Pathology and Diagnostics of Gynecologic Malignancies

Gynecologic malignancies account for roughly 13 % of solid tissue tumors in women. Many of these malignancies, such as many ovarian tumors, first present at an advanced stage, making them difficult to treat. Until recently the analysis of these malignancies was largely limited to hematoxylin-eosin-stained slide examination, supplemented with immunohistochemical stains. Recently, molecular diagnostic techniques have been applied to these tumors with some success, especially with BRCA1/2 mutations and Lynch syndrome analyses. Here, we describe the present molecular diagnostic tests applied to gynecologic malignancies and discuss possible future developments in this field.

RUNXT1 and Palladin Outperform Pathologic Criteria of Malignancy in Predicting Liver Metastases in Primary Pancreatic Endocrine Carcinomas

1 Departments of Anatomic Pathology, Moffitt Cancer Center & Research Institute, Tampa, FL, USA 2 M2Gen Pathology, Moffitt Cancer Center & Research Institute, Tampa, FL, USA 3 Gastrointestinal-Neuroendocrine Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL, USA 4 Department of Pathology, Sir Mortimer Jewish General Hospital, McGill University, Montreal, CA 5 Surgery, Moffitt Cancer Center & Research Institute, Tampa, FL, USA