Massimo Grilli
Casa Sollievo della Sofferenza
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Featured researches published by Massimo Grilli.
Arteriosclerosis, Thrombosis, and Vascular Biology | 1994
M. Margaglione; G Di Minno; E. Grandone; Gennaro Vecchione; E. Celentano; Giuseppe Cappucci; Massimo Grilli; P. Simone; S. Panico; Mario Mancini
We evaluated 106 subjects with and 109 subjects without a history of ischemic stroke. All were attending a metabolic ward. The two groups were compared for major risk factors for ischemic events. A positive family history for ischemic complications of atherosclerosis was more common in subjects with a history of stroke than in those without; moreover, plasma levels of plasminogen activator inhibitor-1 (PAI-1) and tissue-type plasminogen activator (TPA) were higher in patients with documented previous events. A strong positive significant correlation was found between TPA and PAI-1 levels, and an interaction between age and TPA was observed when the sample was stratified according to ages being above or below 70 years. When the patient population was analyzed according to the number of ischemic events, it was found that 62 of the 106 subjects with a history of stroke had experienced more than one ischemic event. Under these conditions, the levels of TPA and PAI-1 still correlated with the occurrence of previous ischemic episodes. As in the whole patient sample, TPA was the strongest discriminator. We conclude that in subjects attending a metabolic ward, TPA and PAI-1 levels consistently help identify subjects with a history of cerebral ischemic episodes and that TPA is the strongest discriminator.
International Journal of Immunopathology and Pharmacology | 2003
Gianluigi Mazzoccoli; Massimo Grilli; Stefano Carughi; Felice Puzzolante; A. De Cata; M. La Viola; Giuliani A; Urbano N; Roberto Tarquini; Federico Perfetto
The immune system plays an important role in the defense against neoplastic disease and immune responses show temporal changes related to circadian variations of antibodies, total lymphocytes in the peripheral blood and cell mediated immune responses. In this study we evaluate, lymphocyte subpopulations and interleukin-2 (IL-2) serum levels in peripheral blood samples collected at four-hour intervals for 24-hours starting at 06.00h from ten healthy subjects aged 65–79 years (mean age ± S.E. 67.28 ±3.11) and from ten subjects suffering from untreated non small cell lung cancer aged 65–78 years (mean age ± S.E. 68.57 ± 1.81). Areas under the curve, mean diurnal levels (mean of 06.00–10.00–14.00 h) and mean nocturnal levels (mean of 18.00–22.00–02.00 h) were calculated, and the presence of circadian rhythmicity was evaluate. When we compared AUC values there was a decrease in CD8bright (T suppressor subset) and an increase in CD16 (natural killer cells) and of IL-2 serum levels in cancer patients. When we compared mean diurnal levels, CD8 (T suppressor/cytotoxic subset) and CD8bright levels were lower, and CD16 levels were higher in cancer patients. When we compared mean nocturnal levels, CD16 and CD25 (T and B activated lymphocytes with expression of the a chain of IL-2 receptor) levels were higher, while CD8, CD8bright, CD20 (total B-cells), TcRd1 (epitope of the constant domain of d chain of T-cell receptor 1) and dTcS1 (epitope of the variable domain of d chain of T-cell receptor1) levels were lower in cancer patients. A clear circadian rhythm was validated for the time-qualified changes in CD4, CD20, HLA-DR with acrophase at night, and CD8, CD8bright, CD8dim, CD16, TcRd1 and dTcS1 with acrophase in the morning in the control group. A clear circadian rhythm was validated for the time-qualified changes in CD4 with acrophase at night, in the group of cancer patients. Results obtained in our study show that lung cancer is associated with anomalies of proportion and circadian variations of lymphocyte subsets that must be considered when adoptive immunotherapy has to be planned.
Geriatrics & Gerontology International | 2011
Gianluigi Mazzoccoli; Michele Inglese; Angelo De Cata; Stefano Carughi; Mariangela Pia Dagostino; Nunzia Marzulli; Marcello Damato; Massimo Grilli; Francesco Giuliani; Antonio Greco
Aim: The nervous, endocrine and immune systems are connected by shared neurotransmitters, hormones and cytokines. The function of these systems shows patterns of circadian rhythmicity and a number of age‐related changes in the 24‐h hormonal and non‐hormonal rhythms have been found in older human beings. The aim of this study was to evaluate integration among the nervous, endocrine and immune systems in the elderly.
European Journal of Endocrinology | 2002
Simonetta Bacci; Massimo Villella; Alessandro Villella; Tommaso Langialonga; Massimo Grilli; Anna Rauseo; Sandra Mastroianno; S. De Cosmo; Raffaele Fanelli; Vincenzo Trischitta
Thrombosis and Haemostasis | 1995
M. Margaglione; G. Di Minno; Elvira Grandone; Gennaro Vecchione; E. Celentano; Giuseppe Cappucci; M. Giordano; Massimo Grilli; P. Simone; S. Fusilli; S. Panico; Mario Mancini
Arteriosclerosis, Thrombosis, and Vascular Biology | 1996
Maurizio Margaglione; Giovanni Diminno; Elvira Grandone; Egidio Celentano; Gennaro Vecchione; Giuseppe Cappucci; Massimo Grilli; Francesco Paolo Mancini; Alfredo Postiglione; Salvatore Panico; Mario Mancini
Age | 2012
Gianluigi Mazzoccoli; Andrea Fontana; Massimo Grilli; Mariangela Pia Dagostino; Massimiliano Copetti; Fabio Pellegrini; Gianluigi Vendemiale
Journal of Biological Regulators and Homeostatic Agents | 2011
Gianluigi Mazzoccoli; Massimo Grilli; Ferrandino F; Massimiliano Copetti; Andrea Fontana; Fabio Pellegrini; Mariangela Pia Dagostino; De Cata A; Gianluigi Vendemiale
Atherosclerosis | 2012
Gianluigi Mazzoccoli; Massimiliano Copetti; Mariangela Pia Dagostino; Massimo Grilli; Andrea Fontana; Fabio Pellegrini; Antonio Greco
Journal of Biological Regulators and Homeostatic Agents | 2012
Gianluigi Mazzoccoli; Mariangela Pia Dagostino; Andrea Fontana; Massimiliano Copetti; Fabio Pellegrini; Massimo Grilli; Antonio Greco