Matthew R. Netherton
Boehringer Ingelheim
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Publication
Featured researches published by Matthew R. Netherton.
Bioorganic & Medicinal Chemistry Letters | 2008
Daniel R. Goldberg; Younggi Choi; Derek Cogan; M. Corson; Rodney P. DeLeon; Amy Gao; L. Gruenbaum; Ming-Hong Hao; D. Joseph; Mohammed A. Kashem; Craig Andrew Miller; Neil Moss; Matthew R. Netherton; Chris Pargellis; Josephine Pelletier; Rosemarie Sellati; Donna Skow; Carol Torcellini; Y.-C. Tseng; Ji Wang; R. Wasti; Brian Werneburg; Jiang-Ping Wu; Zhaoming Xiong
Optimization of pyrazinoindolone inhibitors of MAPKAP-K2 (MK2) provides a reasonable balance of cellular potency and physicochemical properties. Mechanistic studies support the inhibition of MK2 which is responsible for the sub-micromolar cellular efficacy.
Bioorganic & Medicinal Chemistry Letters | 2012
Neil Moss; Zhaoming Xiong; Michael J. Burke; Derek Cogan; Donghong A. Gao; Kathleen Haverty; Alexander Heim-Riether; Eugene R. Hickey; Raj Nagaraja; Matthew R. Netherton; Kathy O’Shea; Philip Dean Ramsden; Racheline Schwartz; Daw-Tsun Shih; Yancey David Ward; Erick Richard Roush Young; Qing Zhang
This paper details exploration of a class of triazole-based cathepsin S inhibitors originally reported by Ellman and co-workers. SAR studies involving modifications across the whole inhibitor provide a perspective on the strengths and weaknesses of this class of inhibitors. In addition, we put the unique characteristics of this class of compounds into perspective with other classes of cathepsin S inhibitors.
Advanced Synthesis & Catalysis | 2004
Matthew R. Netherton; Gregory C. Fu
Journal of the American Chemical Society | 2001
Matthew R. Netherton; Chaoyang Dai; Klaus Neuschutz; Gregory C. Fu
Journal of the American Chemical Society | 2002
Jan H. Kirchhoff; Matthew R. Netherton; Ivory D. Hills; Gregory C. Fu
Angewandte Chemie | 2002
Matthew R. Netherton; Gregory C. Fu
Angewandte Chemie | 2003
Ivory D. Hills; Matthew R. Netherton; Gregory C. Fu
Archive | 2005
Derek Cogan; Matthew R. Netherton
Archive | 2005
Derek Cogan; Ming-Hong Hao; Victor Marc Kamhi; Craig Andrew Miller; Matthew R. Netherton; Alan David Swinamer
Archive | 2013
Asitha Abeywardane; Michael J. Burke; Thomas M. Kirrane; Matthew R. Netherton; Anil K. Padyana; Lana Louise Smith Keenan; Hidenori Takahashi; Michael Robert Turner; Qiang Zhang; Qing Zhang
