Matthias Rueth
Hoffmann-La Roche
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Publication
Featured researches published by Matthias Rueth.
Journal of Medicinal Chemistry | 2011
Michael Prime; Stephen Martin Courtney; Frederick Arthur Brookfield; Richard W. Marston; Victoria Walker; Justin Warne; Andrew E. Boyd; Norman Kairies; Wolfgang von der Saal; Anja Limberg; Guy Georges; Richard A. Engh; Bernhard Goller; Petra Rueger; Matthias Rueth
The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. The development of the phthalazinone template resulted in a potent Aurora-A selective series of compounds (typically >1000-fold selectivity over Aurora-B) that display good pharmacological profiles with significantly improved oral bioavailability compared to the well studied Aurora inhibitor VX-680.
Archive | 2007
David Michael Goldstein; Matthias Rueth
Archive | 2005
Birgit Bossenmaier; Walter-Gunar Friebe; Guy Georges; Matthias Rueth; Edgar Voss
Archive | 2005
Guy Georges; Bernhard Goller; Klaus-Peter Kuenkele; Anja Limberg; Ulrike Reiff; Petra Rueger; Matthias Rueth; Christine Schuell
Archive | 2005
Edward Boyd; Frederick Brookfield; Guy Georges; Bernhard Goller; Sabine Huensch; Petra Rueger; Matthias Rueth; Stefan Scheiblich; Christine Schuell; Der Saal Wolfgang Von; Justin Warne; Stefan Weigand
Archive | 2007
Guy Georges; Bernhard Goller; Anja Limberg; Petra Rueger; Matthias Rueth; Christine Schuell; Mark Stahl
Archive | 2013
Harald Duerr; Frank Herting; Christian Klein; Joerg Thomas Regula; Matthias Rueth; Kay-Gunnar Stubenrauch
Archive | 2013
Richard D. Dimarchi; Eike Hoffmann; Erhard Kopetzki; Matthias Rueth; Georg Tiefenthaler
Archive | 2006
Guy Georges; Bernhard Goller; Hans-Willi Krell; Anja Limberg; Ulrike Reiff; Petra Rueger; Matthias Rueth; Christine Schuell; Mark Stahl
Archive | 2004
Birgit Bossenmaier; Walter-Gunar Friebe; Ulrike Reiff; Matthias Rueth; Edgar Voss
