Max Kugelman

Total chiral synthesis of azole antifungals via α-hydroxylation of ketones

The use of camphorsulfonyl oxaziridines for the preparation of 2′,4′-difluoro-(R)-2-hydroxypropiophenone, (2), a key intermediate for the synthesis of azole antifungals Sch 42427 and ER-30346 (1) in excellent enantiomeric excess and high chemical yield is described.

A novel synthesis of guanine PDE inhibitors via tricyclic imidazopyrimidines

A new method for the preparation of developmental tetracyclic guanine PDE inhibitors via a common tricyclic pyrimidine intermediate is described.

Guanine hydrolysis under basic conditions to substituted imidazoles

Abstract First base induced opening of multicyclic guanines to isolable substituted imidazoles, and possible mechanism for this observation are described.