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Megumu Hatsumura

Kyushu University

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Publication

Featured researches published by Megumu Hatsumura.

Chemosphere | 1993

Modification of the gluconeogenesis is not involved in the co-planar PCB toxicity in highly sensitive guinea pigs

Kazuta Oguri; Megumu Hatsumura; Yuji Ishii; Yoshiko Koga; Noritaka Ariyoshi; Hidetoshi Yoshimura

Abstract Effect of a co-planar PCB, 3,4,5,3′,4′-pentachlorobiphenyl (PenCB) on gluconeogenesis in guinea pigs was compared with that in rats. The key enzyme of gluconeogenesis, phosphoenolpyruvate carboxykinase (PEPCK), in liver cytosol of rats was reduced by PenCB treatment to about 50% of control level. Hypoglycemia was also seen in the rat. On the contrary, the liver cytosol PEPCK activity in guinea pigs was slightly increased by PenCB treatment. Plasma levels of alanine and tryptophan were increased in the rat treated with PenCB, but the level of glycogenic amino acid, alanine, was not raised significantly in the guinea pig. Thus the modification of the gluconeogenesis was not involved in the PenCB toxicity in highly sensitive guinea pigs.

Toxicology Letters | 1996

Significant induction of a 54 kDa protein in rat liver with homologous alignment to mouse selenium binding protein by a coplanar polychlorinated biphenyl, 3,4,5,3',4'-pentachlorobiphenyl and 3-methylcholanthrene

Yuji Ishii; Megumu Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Kazuta Oguri

Chemosphere | 1996

A coplanar PCB induces a selenium binding protein as a major cytosolic protein in rat liver.

Yuji Ishii; Megumu Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Kazuta Oguri

Archives of Biochemistry and Biophysics | 2000

Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Masumi Ikeda; Yuji Ishii; Harutoshi Kato; Daisuke Akazawa; Megumu Hatsumura; Takumi Ishida; Kimihiko Matsusue; Hideyuki Yamada; Kazuta Oguri

Toxicology | 1997

Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Yuji Ishii; Harutoshi Kato; Megumu Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Kazuta Oguri

Hukuoka acta medica | 2001

Effects of a highly toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl on intermediary metabolism: reduced triose phosphate content in rat liver cytosol.

Yuji Ishii; Harutoshi Kato; Megumu Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Hideyuki Yamada; Kazuta Oguri

Hukuoka acta medica | 1995

[Effect of a coplanar PCB on lipid metabolism: the remarkable difference between rats and guinea pigs].

Megumu Hatsumura; Takumi Ishida; Yoichi Ishii; Noritaka Ariyoshi; Kazuta Oguri; Yoshimura H

Journal of Health Science | 2001

Role of the Dioxin-like Toxic Compound Coplanar Polychlorinated Biphenyl, 3,3',4,4',5-Pentachlorobiphenyl in Reducing Hepatic Alcohol Dehydrogenase Levels in Rats in Vivo

Yuji Ishii; Harutoshi Kato; Megumu Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Hideyuki Yamada; Kazuta Oguri

Biological & Pharmaceutical Bulletin | 1993

Metabolic formation of dimethylamine and methylamine from basic drugs containing N-methyl group: a newly established chromatographic assay and its application to the determination of deaminase activity.

Hideyuki Yamada; Takeshi Shimizudani; Megumu Hatsumura; Kazuta Oguri; Hidetoshi Yoshimura

Eisei kagaku | 1998

Study of the Physiological Role of 3, 3', 4, 4', 5-Pentachlorobiphenyl Inducible 54 kDa Protein in Cytosol of Rat Liver (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)

Takumi Ishida; Megumu Hatsumura; Kenji Tasaki; Ayako Fukuda; Yuko Yoshioka; Yuji Ishii; Kazuta Oguri

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Collaboration

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Kazuta Oguri

Kyushu University of Health and Welfare

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Takumi Ishida

Sojo University

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Yuji Ishii

Kyushu University

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Noritaka Ariyoshi

Chiba University

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Harutoshi Kato

Kyushu University

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Hidetoshi Yoshimura

Nakamura Gakuen University

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Hideyuki Yamada

Flinders Medical Centre

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Yoshiko Koga

Kyushu University

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Ayako Fukuda

Kyushu University

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Daisuke Akazawa

Kyushu University

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