Mehmet Okumus

Selenium has a protective effect on ischemia/reperfusion injury in a rat ovary model: biochemical and histopathologic evaluation ☆

BACKGROUND/PURPOSE The aim of the study was to evaluate the effects of selenium (Se) on ischemia/reperfusion (I/R) injury in rat ovaries. METHODS Thirty-five female Sprague-Dawley rats were randomly divided into 5 groups (n = 7): sham (S), I/R1, I/R2, Se1, and Se2. In the I/R1 and Se1 groups, 4 hours of ischemia was followed by 6 hours of reperfusion, and in the I/R2 and Se2 groups, 4 hours of ischemia was followed by 12 hours of reperfusion. In the Se groups, 30 minutes before reperfusion, a single dose of 0.2 mg/kg Se was administered intraperitoneally. The ovarian tissue levels of malondialdehyde (MDA) and nitric oxide (NO), and the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured biochemically. Tissue damage to ovarian tissue was scored by histopathologic examination. RESULTS The I/R groups had significantly higher MDA levels and lower CAT, SOD, and GPx activities than the sham group (P < .05). Although NO levels were significantly higher in the I/R1 group than in the sham group (P < .05), the NO levels in the I/R2 and sham groups were similar. Selenium pretreatment significantly lowered tissue MDA and NO levels and increased tissue SOD and GPx activities in the Se groups, compared with those in the I/R groups (P < .05). Catalase activities were significantly higher in the Se2 group than in the I/R2 group (P < .05). Catalase activities were higher in the Se1 group than in the I/R1 group, but the difference was not statistically significant. Treatment with Se significantly decreased the ovarian tissue damage scores in the Se2 group compared with those in the I/R2 group (P < .05). CONCLUSION Selenium is effective in preventing tissue damage induced by I/R in rat ovaries.

The histopathological investigation of the effect on regional and systemic tissues of the application of Medicinal Plant Extract Ankaferd Blood Stopper in deep tissue injuries in Rats

BACKGROUND This study was planned to evaluate both the histopathological changes under light microscope as well as the systemic organ effects following application of Ankaferd Blood Stopper® (ABS) (a mixture of five plant extracts) in an animal model of deep tissue hemorrhage. METHODS A total of 50 Wistar Albino rats were divided into five groups of 10 rats each. The rats underwent femoral vein puncture and were treated with ABS tampon, ABS spray, or Surgicel, and one group was left untreated. After two weeks, each group underwent partial tissue excision from the same femoral region as well as from the brain, heart, kidney, and liver. RESULTS The specimens from all groups were obtained from the femoral region after two weeks and evaluated under light microscope. The light microscope revealed no histopathological changes in neurovascular structures or in deep connective tissues in any of the groups. CONCLUSION ABS provided hemostasis and was observed to stop bleeding. There were no histopathological changes at the tissue level and no pathological effects in other organs tissues under light microscope, and the remote organ tissue remained clear.

Çok nadir bir akut batın nedeni: Gossipiboma

A surgical sponge left in abdominal cavity following completion of the operation (Gossypiboma) is a rare entity. They may not only cause aseptic reactions without significant symptom, but they may also lead to exuda tive reaction which is manifested in the early phase with non-specific symptoms or they may manifest in the late phase with abscess and palpable mass symptoms. Surgical gauze pad will initiate a granulomatous reaction and it may appear as a large intra-abdominal mass. This condition is referred as gossypiboma. Gossypiboma should be considered in patients who have abdominal pain and intraabdominal abscess symptoms particularly in patients had abdominal operation previously. In this study, we present radiological findings of a 37-years old male pa tient who referred to our clinic with complaints of abdominal pain and fever and diagnosed as gossypiboma.

Proparacaine Toxicity Caused by the Drug Abuse: A Case Report

DOI: 10.4328/JCAM.1361 Received: 31.10.2012 Accepted: 19.11.2012 Publihed Online: 21.11.2012 Corresponding Author: Selim Bozkurt, Kahramanmaras Sutcu Imam Universitesi Tip Fakultesi, Acil Tip AD. Kahramanmaras, Turkiye. T.: +90 3442211431 F.: +90 3442212371 GSM: +905363661789 E-Mail: selimbozkurt01@yahoo.com Ozet Eczanelerden recetesiz temin edilen topikal anestezikler gecici rahatlatici etkilerinden dolayi ozellikle sanayide calisan isciler tarafindan bilincsiz kullanilmaktadir. Zamanla kullanicilarin bir kisminda bu tur ilaci daha sik kullanma ihtiyaci ortaya cikmaktadir. Bu ilaclar kornea uzerine direkt toksik etkileri ile veya gozyasi stabilitesini bozarak toksik keratopatiye yol acmaktadirlar. Zamaninda mudahale edilmeyen basit keratopatiler ilerleyerek kornea-skleral incelme, kalici korneal opasite ve hatta perforasyona neden olabilmektedir. Kontrolsuz topikal anestezik kullanan ve ilac bagimliligi gelisen toksik keratopatili bir olguyu sunmayi amacladik.

Evaluation of Judicial Reports Which Executing on Emergency Service and Fixed Deficiencies

DOI: 10.4328/JCAM.2039 Received: 28.08.2013 Accepted: 04.10.2013 Printed: 01.05.2015 J Clin Anal Med 2015;6(3): 331-4 Corresponding Author: Selim Bozkurt, Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Acil Tıp AD. Kahramanmaraş, Türkiye. T.: +90 3442211431 F.: +90 3442212371 GSM: +905363661789 E-Mail: selimbozkurt01@yahoo.com Özet Amaç: Acil serviste çalışan hekimler adli olaylarla sıkça karşılaşıp adli rapor düzenleme yükümlülüklerini yerine getirmektedirler. Düzenlenen bu raporlarda kimi zaman eksiklik ve/veya yanlışlıklar bulunmaktadır. Bu çalışmada hastanemiz acil servisinde düzenlenen adli raporlar incelenip eksikliklerin ortaya konulması amaçlandı. Gereç ve Yöntem: Bu çalışmada Kahramanmaraş Sütçü İmam Üniversitesi Acil Servisinde Ocak 2011-Aralık 2012 tarihleri arasında düzenlenen 1218 adli rapor değerlendirilerek eksiklikleri belirlendi. Bulgular: İncelemeye alınan iki yıllık dönemde 1218 olguya adli rapor düzenlendiği gözlendi. En sık trafik kazası %25.9, zehirlenme %17 ve düşme %15.8 sonucunda adli rapor düzenlendiği tespit edildi. Raporların %4’ünde ise olay türünün belirtilmediği gözlendi. Adli raporların %33.8’inde doğum tarihi, %37.1’inde olay tarihi, %49,3’ ünde olay saati, %30’ unda muayene tarihi, %37.9’ unda muayene saati, %56’ sında rapor tarihi, %78.4’ünde rapor saati yazılmamıştı. Raporların %96.4’ünde laboratuar sonuçları, %95.9’unda radyolojik tetkik sonuçları, %98.4’ ünde konsültan görüşü yazılmamıştı. %94’ünde alkol durumuyla ilgili bilgiye rastlanmadı. Raporların büyük çoğunluğu geçici rapor olarak düzenlenmişti. Hekim isim ve imzası çoğunlukla varken yalnızca %9.3’ünde teslim alan görevlinin ismi ve imzası vardı. Raporların %8.6’sında bir yıllık acil asistanın dahi okuyamadığı ifadeler vardı. Tartışma: Bu çalışmada adli rapor yazım aşamasında hekimlerin gerekli özen ve titizliği göstermediği tespit edilmiştir.

Analysis of cardiac and pulmonary injuries resulting from an experimental penetrating thoracic injury

BACKGROUND This study was planned to analyze the internal and external anatomical findings of cardiac injuries and the presence of accompanying pulmonary injuries in intentionally inflicted thoracic injuries to swine models. METHODS We inflicted a penetrating heart injury in six suis domesticus female swine models. Two cardiac injuries, one on the left paratracheal of fourth intercostal space (ICS) and the other on the right side were inflicted on each model by the same researcher using a 20-cm long scalpel. All animals were then sacrificed for morphological evaluation. RESULTS After strikes to the left fourth ICS, external evaluation showed that 50% of the subjects suffered a single laceration and that 33% suffered multiple lacerations. Internal evaluation showed additional intracardiac injuries in all five subjects. However, the subject that suffered a single laceration on the outer surface of the heart had multiple internal injuries while another subject that had multiple outer lacerations had only one intracardiac injury. Only three subjects suffered cardiac injuries and only two out of those three with pulmonary injuries after right fourth intercostal intrusions. CONCLUSION This experiment has shown that external evaluation of the heart tissue may not alone be sufficient to determine the extent of cardiac injuries and accompanying pulmonary injuries caused by penetrating thoracic injuries.

Rare Complication of Pica: Eosofagus Obstruction Resulting from Pebble Ingestion

Introduction: While the chief cause of eosofagus foreign bodies in children is ingestion of coins, the main cause in adults is impacted food, whereas in mentally retarded patients unusual foreign body ingestions may be encountered. Case Report: A 33 year old female patient presented to the Emergency Department with difficulty in swallowing saliva. The lateral cervical X-Ray revealed an appearance compatible with pebble. The history revealed a pica of pebble from her childhood. Conclusion: Because the literature has only very rare reports on eosofagus impaction due to a pebble, this case aimed to present and discuss this in the light of the literature.

Arteria lusoria: a very rare cause of esophageal obstruction in a hypoxemic patient.

A male patient aged 50 years presented to the emergency department with a complaint of dysphagia after ingestion of a whole plum without chewing. His history revealed a diagnosis of schizophrenia 15 years ago. This was the patient’s second presentation to hospital with this complaint. At the first-step hospital, his relatives and the physicians did not believe the patient due to his schizophrenia after a posteroanterior X-ray examination was reported as normal. The physical examination was unremarkable, except for hypoxemia with a saturation of 75-80%. The thoracic computed tomography (CT) revealed an esophageal foreign body compatible with a silhouetted plum image at a distance of <7 cm after the epiglottis and a concomitant right subclavian artery originating as the last branch of the aortic arch (Figure 1). The CT revealed an obstruction caused by the plum, which was lodged in the esophagus just superior to where the artery followed a retroesophageal course to cross the midline (Figure 2). There was no tracheal compression or any finding that explained the hypoxemia in the CT examination. The patient underwent flexible endoscopic approach, and the foreign body (plum) was removed by breaking it into pieces and pushing it through the esophagus into the stomach. The oxygen saturation increased to within normal range, (95-97%), after endoscopic administration. The patient was discharged home after a 6-hour observation period with relief of his complaints.

Bir 112 acil servise bir yıllık başvurulardaki dermatolojik hastalıkların değerlendirilmesi

Objective: This study aimed to determine the clinical characteristics of the patients admitted to 112 emergency services with dermatological disorders in Kayseri city in 2011. Methods: Data were obtained from the records of Emergency Health Care Services Department. Dermatological reasons for calling the 112 emergency services and dermatological cases diagnosed by physicians of 112 emergency services were recorded. Kayseri has a population for about 1.25 million. Kayseri 112 emergency services contain 45 physicians, 224 healthcare personnel. Results: In 2011, 2 405 367 calls were occurred in Kayseri, 112 Emergency Service. Of these calls 920 502 (37.5%) real and necessary calls and the rest 1 484 865 (62.5%) were unnecessary calls. A total of 52472 (5.7% of real calls) cases were determined in real calls. Of the cases, 600 (1.14 % of real calls) patients with dermatological disorders were observed. The most common dermatological reason for calling the 112 emergency services was other insect bite (396 calls, 66%) and the most diagnosed dermatological case was other insect bite (396 cases, 66%). Total number of calls about burn were 131 (21,8 %), pruritus were 29 (4.83%), skin wound or infection 18 (3%), bee bite 17 (2.83%), scorpion bite 9 (1.5%). Conclusion: Dermatological disorders in 112 Emergency Service are not rare. Further studies are needed involving the 112 Emergency Service and Emergency Departments in hospitals. J Clin Exp Invest 2013; 4 (1): 47-50

Comparison of the Results of Venous Blood Gas and Laboratory Measurement of Potassium

Son zamanlarda yapılan çalışmalarda venöz kan gazının pH, pCO2 ve bikarbonat değerlendirilmesi amacıyla arteryal kan gazı yerine kullanılabileceği gösterilmektedir (1-3). Ayrıca venöz kan gazı kullanımı ile arteryal kan gazı alımı sırasında hastada ve sağlık çalışanlarında oluşabilecek komplikasyonlar azaltılabilmektedir (3). Kan gazı analizinde pH, bikarbonat, pCO2 ve pO2’nin yanısıra sodyum, potasyum ve kalsiyum gibi elektrolit değerleri de ölçülebilmektedir. Abstract