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Meizhong Xu

Incyte

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Publication

Featured researches published by Meizhong Xu.

Bioorganic & Medicinal Chemistry Letters | 2009

Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.

David M. Burns; Yun-Long Li; Eric Shi; Chunhong He; Meizhong Xu; Jincong Zhuo; Colin Zhang; Ding-Quan Qian; Yanlong Li; Richard Wynn; Maryanne Covington; Kamna Katiyar; Cindy Marando; Jordan S. Fridman; Peggy Scherle; Steve Friedman; Brian Metcalf; Wenqing Yao

A serendipitous discovery that the metalloprotease binding profile of a novel class of 2-carboxamide-3-hydroxamic acid piperidines could be significantly attenuated by the modification of the unexplored P1 substituent enabled the design and synthesis of a novel 2-carboxamide-1-hydroxamic acid cyclohexyl scaffold core that exhibited excellent HER-2 potency and unprecedented MMP-selectivity that we believe would not have been possible via conventional P1 perturbations.

Archive | 2007

Imidazotriazines and imidazopyrimidines as kinase inhibitors

Jincong Zhuo; Meizhong Xu; Chunhong He; Colin Zhang; Ding-Quan Qian; David M. Burns; Yun-Long Li; Brian Metcalf; Wenqing Yao

Archive | 2005

Lactam compounds and their use as pharmaceuticals

Wenqing Yao; Chunhong He; David M. Burns; Jincong Zhuo; Meizhong Xu; Colin Zhang; Ding-Quan Qian; Brian Metcalf

Archive | 2005

N-substituted piperidines and their use as pharmaceuticals

Wenqing Yao; Meizhong Xu; Colin Zhang; Yanlong Li; Jincong Zhuo; Brian Metcalf

Archive | 2005

2-Methylprop anamides and their use as pharmaceuticals

Wenqing Yao; Colin Zhang; Jincong Zhuo; Meizhong Xu; Konstantinos Agrios; Brian Metcalf

Archive | 2007

Triazolotriazines as kinase inhibitors

Jincong Zhuo; Colin Zhang; Meizhong Xu; Ding-Quan Qian; Wenqing Yao; Ravi Kumar Jalluri

Archive | 2016

IMIDAZOPYRIDINES AND IMIDAZOPYRAZINES AS LSD1 INHIBITORS

Liangxing Wu; Leah C. Konkol; Neil Lajkiewicz; Liang Lu; Meizhong Xu; Wenqing Yao; Zhiyong Yu; Colin Zhang; Chunhong He

Archive | 2014

SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3

Wenqing Yao; Colin Zhang; Meizhong Xu; Jincong Zhuo; Chunhong He

Bioorganic & Medicinal Chemistry Letters | 2008

Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.

Wenqing Yao; Jincong Zhuo; David M. Burns; Yun-Long Li; Ding-Quan Qian; Colin Zhang; Chunhong He; Meizhong Xu; Eric Shi; Yanlong Li; Cindy Marando; Maryanne Covington; Xiangdong Liu; Max Pan; Jordan S. Fridman; Peggy Scherle; Zelda R. Wasserman; Gregory Hollis; Kris Vaddi; Swamy Yeleswaram; Robert Newton; Steve Friedman; Brian Metcalf

Archive | 2013

Fused Pyrazoles as FGFR Inhibitors

Jincong Zhuo; Meizhong Xu; Ding-Quan Qian

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Colin Zhang

Incyte

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Wenqing Yao

Incyte

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Jincong Zhuo

Incyte

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Chunhong He

Incyte

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Brian Metcalf

Incyte

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Ding-Quan Qian

Incyte

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David M. Burns

Incyte

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Yanlong Li

Incyte

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Cindy Marando

Incyte

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Jordan S. Fridman

Incyte

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