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Melean Visnick

Pfizer

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Publication

Featured researches published by Melean Visnick.

Bioorganic & Medicinal Chemistry Letters | 2010

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent

Tadashi Honda; Eric M. Padegimas; Emilie David; Chitra Sundararajan; Karen T. Liby; Charlotte R. Williams; Michael B. Sporn; Melean Visnick

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride (CDDO anhydride) has been synthesized, which is the first example of an oleanane triterpenoid anhydride. CDDO anhydride shows potency similar to or higher than the corresponding acid (CDDO) in various in vitro and in vivo assays related to inflammation and carcinogenesis. Notably, preliminary phamacokinetics studies show that CDDO anhydride levels are higher than CDDO levels in mouse tissues and blood. Further evaluation of CDDO anhydride is in progress.

Archive | 2009

Compounds including an anti-inflammatory pharmacore and methods of use

Eric Anderson; Gary L. Bolton; Deborah A. Ferguson; Xin Jiang; Robert M. Kral; Patrick M. O'Brien; Melean Visnick

Bioorganic & Medicinal Chemistry Letters | 2007

Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinaseγ

Thomas B. Lanni; Keri Lynn Greene; Christine Nylund Kolz; Kimberly Suzanne Para; Melean Visnick; James L. Mobley; David T. Dudley; Theodore J. Baginski; Marya Liimatta

Archive | 2003

Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k

Nicole Chantel Barvian; Christine Nylund Kolz; Kimberly Suzanne Para; William Chester Patt; Melean Visnick

Archive | 2004

3-substituted indoles and derivatives thereof as therapeutic agents

Kimberly Suzanne Para; Charles J. Stankovic; Melean Visnick

Archive | 2012

C4-monomethyl triterpenoid derivatives and methods of use thereof

Eric Anderson; Christopher F. Bender; Xiaofeng Liu; Xin Jiang; Melean Visnick

Archive | 2011

Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators

Eric Anderson; Gary Louis Bolton; Bradley William Caprathe; Xin Jiang; Chitase Lee; William H. Roark; Melean Visnick

Archive | 2016

C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses

Melean Visnick; Xin Jiang; Martha R. Hotema; Chitase Lee; Bradley William Caprathe; William H. Roark; Gary Louis Bolton

Archive | 2016

IMIDAZOLYL TRICYCLIC ENONES AS ANTIOXIDANT IFLAMMATION MODULATORS

Xin Jiang; Bradley William Caprathe; Chitase Lee; Gary Louis Bolton; Christopher F. Bender; Melean Visnick

Archive | 2016

Énones tricycliques d'imidazolyle comme modulateurs antioxydants de l'inflammation

Xin Jiang; Bradley William Caprathe; Chitase Lee; Gary Louis Bolton; Christopher F. Bender; Melean Visnick

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Kimberly Suzanne Para

Pfizer

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Christine Nylund Kolz

Pfizer

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Karen T. Liby

Cornell University

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Michael B. Sporn

University of Arkansas for Medical Sciences

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Nicole Chantel Barvian

Pfizer

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Tadashi Honda

University of Arkansas for Medical Sciences

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William Chester Patt

Pfizer

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Charlotte R. Williams

Dartmouth College

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Chitra Sundararajan

Dartmouth College

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Emilie David

Dartmouth College

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