Melvin L. Goldman

Orthostatic Hypotension, Anhidrosis, and Impotence

Anhidrosis and impotence occur frequently with idiopathic orthostatic hypotension. Two new cases of this syndrome, which occurs chiefly in males over 40 years of age, are herewith described. Postural vertigo and/or syncope, weakness, and anhidrosis or hypohidrosis are common symptoms, and a marked fall in systolic and diastolic blood pressure is noted when the patients stand. The pathologic physiology of the syndrome is discussed and various forms of therapy, none of them especially satisfactory, are reviewed.

THE EFFECTS OF THE RICE DIET UPON THE BLOOD PRESSURE OF HYPERTENSIVE INDIVIDUALS

Excerpt Since Kempner1reported alleviation of the elevated blood pressure in cases of arterial hypertension and renal diseases by the use of a diet composed of rice, fruit juices and vitamins, cont...

Coarctation of the aorta: Photo-electric plethysmography and direct arterial blood pressure measurement as an aid in diagnosis

T HE clinical diagnosis of coarctation of the aorta can be made without difficulty when there is enough constriction of the aorta to cause collateral circulation to become well established. However, the degree of constriction may vary from a slight indentation to practically complete obliteration. The site of coarctation may also vary and anomalies of the great vessels may be present. Therefore, it is advantageous to establish the site and degree of the constriction in order to decide whether or not the condition can be corrected surgically and whether operation is likely to be hazardous. The purpose of this report is to present the combination of two well established methods for the study of blood flow and blood pressure, namely, photo-electric plethysmography and direct measurements of arterial blood pressure as an aid to the diagnosis and location of coarctation of the aorta. By these means the relative blood flow of peripheral parts can be estimated and accurate blood pressure in an extremity can be measured.

Arterial Hypertension in Dogs: I. Methods

Various methods were devised in attempts to produce chronic hypertension in dogs. The induction of anxiety was unsuccessful. Bilateral renal denervation combined with injections of epinephrine appeared to produce temporary hypertension. Permanent hypertension was induced by unilateral renal ischemia with the other kidney left intact only in dogs of nervous temperament. Certain dogs were extremely resistant to the development of hypertension even when several methods were combined. Neurogenic hypertension induced by section of the moderator nerves is probably a true hypertension. It is obvious that the host factor may be as important as the method employed.

Immediate pressor effect of desoxycorticosterone acetate in arterial hypertension

Abstract 1.1. Five mg. of DCA, ∗ ∗Supplied by Schering Corporation. progesterone, Δ 5 pregnenolone, testosterone, dehydroisoandrosterone acetate, 17-hydroxy-11-dehydro-corticosterone †2 †2Supplied by Parke, Davis & Company. (dissolved in 2.5 cc. of propylene glycol) and 10 ml. of adrenal cortical extract were injected intravenously into twenty patients, of whom eleven exhibited elevated diastolic pressures and nine did not. 2.2. Of these substances only DCA acted as a pressor substance and then only in hypertensive subjects. Its pressor effect was prolonged.

Chromaffin-Reacting Cells of Digital Skin in Peripheral Vascular Diseases

* From the Departments of Pathology, Surgery, and Internal Medicine, Washington University School of Medicine, Barnes Hospital and U. S. Veterans Administration Hospital, St. Louis, Missouri. Supported by grants (CRT-5017) and (RG 4192 C3) from the National Institutes of Health, Public Health Service, Bethesda, Maryland. t United States Public Health Trainee in Experimental Pathology (Grant No. CRT-5017). ‡ We are grateful to Dr. H. N. K. Luke and Dr. R. A. Sutter for these samples. Chromaffin-positive granules have been found in human skin,1 . 4 and may play a role in controlling skin circualtion.4 A technique of demonstrating these chromaffin-reacting cells in punch biopsies of normal human digital skin