Mercedes Garrido

Synthesis and Reactivity of β-Carboline-Hydantoin Systems

Abstract The synthesis of 2,5-disubstituted 1,3-dioxo-6H-1,2,3,5,11,11a-hexahydroimidazo[1, 5-b]-β-3a-y and the reduction of carbolines 3m-r with different amounts of lithium aluminium hydride is described.

Synthesis, structure and cytostatic activity of a series of 2-substituted perimidines☆

Abstract The synthesis and cytotoxic activity of a series of 2-substituted perimidines is reported. The presence of a basic nitrogen in position 2 of the chain is very important for activity. The maximal activity appears in the 2-dimethylaminomethylene derivative.