Michael Beller

Acute Fluoride Poisoning from a Public Water System

BACKGROUND Acute fluoride poisoning produces a clinical syndrome characterized by nausea, vomiting, diarrhea, abdominal pain, and paresthesias. In May 1992, excess fluoride in one of two public water systems serving a village in Alaska caused an outbreak of acute fluoride poisoning. METHODS We surveyed residents, measured their urinary fluoride concentrations, and analyzed their serum-chemistry profiles. A case of fluoride poisoning was defined as an illness consisting of nausea, vomiting, diarrhea, abdominal pain, or numbness or tingling of the face or extremities that began between May 21 and 23. RESULTS Among 47 residents studied who drank water obtained on May 21, 22, or 23 from the implicated well, 43 (91 percent) had an illness that met the case definition, as compared with only 6 of 21 residents (29 percent) who drank water obtained from the implicated well at other times and 2 of 94 residents (2 percent) served by the other water system. We estimated that 296 people were poisoned; 1 person died. Four to five days after the outbreak, 10 of the 25 case patients who were tested, but none of the 15 control subjects, had elevated urinary fluoride concentrations. The case patients had elevated serum fluoride concentrations and other abnormalities consistent with fluoride poisoning, such as elevated serum lactate dehydrogenase and aspartate aminotransferase concentrations. The fluoride concentration of a water sample from the implicated well was 150 mg per liter, and that of a sample from the other system was 1.1 mg per liter. Failure to monitor and respond appropriately to elevated fluoride concentrations, an unreliable control system, and a mechanism that allowed fluoride concentrate to enter the well led to this outbreak. CONCLUSIONS Inspection of public water systems and monitoring of fluoride concentrations are needed to prevent outbreaks of fluoride poisoning.

An outbreak of tinea corporis gladiatorum on a high school wrestling team

BACKGROUND An outbreak of tinea corporis occurred in members of a high school wrestling team during the 1992-1993 season. OBJECTIVE To control the outbreak, we conducted an epidemiologic investigation. METHODS We examined 28 team members and obtained skin scrapings from 16. To control the outbreak we recommended (1) griseofulvin for 1 month to treat persons with more than two lesions or any facial lesion(s) and topical ketoconazole or econazole for 1 month to treat all others and (2) that wrestlers be excluded from wrestling until 10 days of topical treatment or 15 days of oral treatment had been completed. RESULTS Twenty-one wrestlers had lesions consistent with tinea corporis and 10 had Trichophyton tonsurans infection confirmed by culture. A new eruption developed in 12 wrestlers after the recommendations were implemented. CONCLUSION This is the third and largest outbreak of tinea corporis gladiatorum to be described in the United States. Appropriate control measures have not yet been established.

Large summertime influenza A outbreak among tourists in Alaska and the Yukon Territory

We investigated a large summertime outbreak of acute respiratory illness during May-September 1998 in Alaska and the Yukon Territory, Canada. Surveillance for acute respiratory illness (ARI), influenza-like illness (ILI), and pneumonia conducted at 31 hospital, clinic, and cruise ship infirmary sites identified 5361 cases of ARI (including 2864 cases of ILI [53%] and 171 cases of pneumonia [3.2%]) occurring primarily in tourists and tourism workers (from 18 and 37 countries, respectively). Influenza A viruses were isolated from 41 of 210 patients with ILI at 8 of 14 land sites and 8 of 17 cruise ship infirmaries. Twenty-two influenza isolates were antigenically characterized, and all were influenza A/Sydney/05/97-like (H3N2) viruses. No other predominant pathogens were identified. We estimated that >33,000 cases of ARI might have occurred during this protracted outbreak, which was attributed primarily to influenza A/Sydney/05/97-like (H3N2) viruses. Modern travel patterns may facilitate similar outbreaks, indicating the need for increased awareness about influenza by health care providers and travelers and the desirability of year-round influenza surveillance in some regions.

Incremental effectiveness of 2 doses of measles-containing vaccine compared with 1 dose among high school students during an outbreak

A measles outbreak occurred among a highly vaccinated population in Alaska during 1998, providing an opportunity to determine the incremental efficacy of >or=2 doses of measles-containing vaccine (MCV) compared with 1 dose. Of 33 confirmed case patients identified, 31 had been vaccinated with 1 dose of MCV, 1 had received 2 doses, and vaccination status was unknown in 1 case. Seventy percent of cases were school-associated; 58% of cases occurred in 2 high schools. Of 3679 students attending the 2 schools, 50.4% and 45.5% had received >or=2 doses of MCV before measles introduction at the schools. The relative risk of developing measles among persons vaccinated with >or=2 doses of MCV compared with 1 dose was 0.06 (95% confidence interval, 0.01-0.44; P<.001), yielding an estimated incremental vaccine efficacy of 94.1% (95% confidence interval, 55.9%-99.2%; P<.001). Rapid implementation of a mandatory second-dose MCV requirement probably limited the extent of this outbreak.

Helicobacter pylori infection among non-Native educators in Alaska

Objectives. To determine seroprevalence of H. pylori infection in non-Native educators residing in urban or rural settings in Alaska, and to determine potential risk factors associated with infection in this population. Study Design. A cross-sectional survey of non-Native educators residing in urban or rural settings in Alaska. Methods. Participants completed a questionnaire detailing aspects of residential life; H. pylori antibody status was determined by a commercial assay. Results. Of the 203 non-Native participants, 49 (24%) had antibody to H. pylori. Univariate analysis demonstrated that the mean age of seropositive participants was higher than of seronegatives (48 vs. 42 years, respectively, p = .001). In addition, participants who had experienced childhood crowding were more likely to test seropositive for H. pylori (p = .058). On multivariate analysis, only age > or = 40 was associated with infection. No difference in median hemoglobin or ferritin levels were noted among seropositive and seronegative participants. There was no increased risk of seropositivity among participants who had lived in an Alaska Native village or in a developing country for > or = 6 months. Conclusions. Overall, 24% of non-Native educators residing in rural Alaska tested positive by serology for H. pylori. Age > or = 40 years was associated with infection. Median hemoglobin or ferritin levels did not differ significantly among seropositive and seronegative participants.

Use of Liver Function Tests to Predict the Magnitude of an Outbreak of Hepatitis A

The results of liver function tests allowed local and state public health professionals in Alaska to accurately predict the magnitude of an outbreak of hepatitis A.