Michael E. Houlihan

Separating Phonological and semantic processing in auditory sentence processing: A high-resolution event-related brain potential study

Phonological and semantic processing was studied using high‐resolution event‐related brain potentials (ERPs) during a sentence‐matching task to investigate the spatial distribution of the phonological mismatch negativity (PMN) and the N400 response. It was hypothesized that the two components were spatially separable and that the activity matched prior localization knowledge. Participants examined visual–auditory sentence pairs that related within a semantic hierarchy (e.g., visual: “The man is teaching in the classroom”; Auditory: “The man is in the…school/barn”). Semantic congruency was varied for the final words of the spoken sentences. Incongruent words mismatched expectation in terms of both the initial phonological features (unexpected sound) and semantic features (unexpected meaning). In addition, the category–exemplar probability of the final words was either high or low, with low probability words being more difficult to anticipate. Low probability words were predicted to selectively affect PMN activity. We found that incongruent words elicited a PMN (287 msec) and a N400 (424 msec), for both the high and low probability words. As expected, low probability congruent words elicited a small PMN but no N400. In contrast, high probability congruent words elicited neither a detectible PMN nor a N400. The primary PMN sources were in left inferior frontal and inferior parietal lobes. The primary N400 source activation occurred along the left perisylvian cortex, consistent with prior N400 source localization work. From these results, it was concluded that the PMN and N400 were localized to separate cortical language (and memory) regions and had different source activation patterns. Hum. Brain Mapping 22:42–53, 2004.

Effects of nicotine and smoking on event-related potentials: A review

Event-related potentials can serve as an adjunct to reaction time in elucidating the effects of nicotine on rapid human information processing. We review the literature related to nicotine and event-related potentials. Although evidence indicates that, in the visual modality, nicotine enhances early perceptual processing and in certain instances speeding stimulus evaluation, the bulk of nicotines effects seem to be on enhancing response preparation and response execution.

Effects of Experimentally Induced Pain on Mismatch Negativity

Abstract: Previous research has found that pain can exert a disruptive effect on cognitive processing. This experiment was conducted to extend previous research with participants with chronic pain. This report examines pains effects on early processing of auditory stimulus differences using the Mismatch Negativity (MMN) in healthy participants while they experienced experimentally induced pain. Event-related potentials (ERPs) were recorded using target and standard tones whose pitch differences were easy- or difficult-to-detect in conditions where participants attended to (active attention) or ignored (passive attention) the stimuli. Both attention manipulations were conducted in no pain and pain conditions. Experimentally induced ischemic pain did not disrupt the MMN. However, MMN amplitudes were larger to difficult-to-detect deviant tones during painful stimulation when they were attended than when they were ignored. Also, MMN amplitudes were larger to the difficult- than to the easy-to-detect tones in...

Smoking/nicotine affects the magnitude and onset of lateralized readiness potentials.

AbstractSmoking/nicotine improves cognitive performance for a variety of tasks. In most cases, reaction time (RT) is generally shorter after smoking/nicotine. While there may be some slight facilitation of stimulus-evaluation processing, most of the RT effects of nicotine appear to take place following the response-selection stage. This study investigated possible effects (in smokers) of smoking/nicotine on response preparation and execution processes using the lateralized readiness potential (LRP). On each trial, a warning stimulus preceded an imperative stimulus by 1.2s. The warning stimulus completely specified the correct response to the imperative stimulus. The study was completed in two morning sessions in which 4 cigarettes were smoked in each session. The nicotine yield of the cigarettes varied between sessions (0.05mg or 1.1mg). Maximum amplitudes of both the stimulus and response-locked LRPs were larger in the 1.1 mg session. For both stimulus- and response-locked LRPs, smoking the 1.1 mg cigare...

The Type B Behavior Pattern as a Moderating Variable of the Relationship between Stressor Chronicity and Health Behavior

To test the hypotheses that Type B individuals would engage in more preventive and less risk-related behaviors under high stress than Type As, 155 students were administered questionnaires pertaining to the TABP, daily hassles, and health behavior. As predicted, in six out of seven regression analyses, Type Bs engaged in more preventive, and fewer risk-related behaviors under high stress, than those who self-reported as Type A. Self-regulation mechanisms are proposed to help account for these effects.

The effect of pain on involuntary and voluntary capture of attention

There is converging evidence for the notion that pain affects a broad range of attentional domains. This study investigated the influence of pain on the involuntary capture of attention as indexed by the P3a component in the event‐related potential derived from the electroencephalogram.