Michael L. Mitchell

Chemical‐Enzymatic Synthesis of Iminocyclitol Phosphonic Acids

Fuculose 1-phosphate and fructose-diphosphate aldolases were employed in the chemoenzymatic synthesis of the iminocyclitols 1 and 2 possessing a phosphonic acid moiety. These compounds are useful as core synthons for the development of specific glycosyltransferase inhibitors.

Synthesis and evaluation of six-membered GDP-iminocyclitol

Fructose-diphosphate aldolase was employed in the chemoenzymatic synthesis of six-membered GDP-iminocyclitols. These compounds were evaluated for activity against α-1,3-fucosyltransferases and found to be potent inhibitors.