Manoj C. Desai

Simple synthesis of (±)-β-trans-bergamotene

Abstract (±)-β- trans -Bergamotene ( 4 ) has been synthesized in five steps from geranylacetone using intramolecular ketene-olefin cycloaddition as a key step.

Highly reactive equivalents of allylidenetriphenylphosphoranes for the stereospecific synthesis of 1,3-dienes by cis-olefination of hindered aldehydes

Ylides derived from 3-dimethylaminopropyltriphenylphosphonium salts react smoothly and stereospecifically with even hindered aldehydes to form Z-olefins which are easily converted to 1,3-dienes.

Higher isoprenoids-XI: Partial syntheses from cycloartenol, cyclolaudenol-Part 3: Cyclobuxophyllinine-m, cyclobuxophylline-k and buxanine-m

Abstract 3β-Acetoxy-9,19-cyclo-4,4,14α-trimethyl-5α-pregnan-20-one, an intermediate readily accessible from cycloartenol/cyclolaudenol has been transformed into cyclobuxophyllinine-M, an alkaloid isolated from certain Buxus Spp. This compound has been earlier converted into the closely related alkaloids cyclobuxophilline-K and buxanine-M. The present work formally constitutes the synthesis of these alkaloids from cycloartenol.

A novel method for functionalization of C-4 methyl in triterpenoids. A synthesis of cycloeucalanone

Abstract Functionalization of 4α-methyl group in cycloartane-type triterpenoids has been accomplished utilizing, in the key step, photolytic decomposition of an hypoiodite derived from a 3β-hydroxymethyl-4,4-dimethyl precursor. The synthesis of cycloeucalanone from cyclolaudanone is reported.