Michael R. Wood
Merck & Co.
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Publication
Featured researches published by Michael R. Wood.
Bioorganic & Medicinal Chemistry Letters | 2009
Michael R. Wood; Kathy M. Schirripa; June J. Kim; Amy G. Quigley; Craig A. Stump; Ian M. Bell; Rodney A. Bednar; John F. Fay; Joseph G. Bruno; Eric L. Moore; Scott D. Mosser; Shane Roller; Christopher A. Salvatore; Stefanie A. Kane; Joseph P. Vacca; Harold G. Selnick
A novel class of CGRP receptor antagonists was rationally designed by modifying a highly potent, but structurally complex, CGRP receptor antagonist. Initial modifications focused on simplified structures, with increased flexibility. Subsequent to the preparation of a less-potent but more flexible lead, classic medicinal chemistry methods were applied to restore high affinity (compound 22, CGRP Ki=0.035 nM) while maintaining structural diversity relative to the lead. Good selectivity against the closely related adrenomedullin-2 receptor was also achieved.
Bioorganic & Medicinal Chemistry Letters | 2010
Michael R. Wood; Kathy M. Schirripa; June J. Kim; Rodney A. Bednar; John F. Fay; Joseph G. Bruno; Eric L. Moore; Scott D. Mosser; Shane Roller; Christopher A. Salvatore; Joseph P. Vacca; Harold G. Selnick
A previously utilized quinoline-for-N-phenylamide replacement strategy was employed against a central amide in a novel class of CGRP receptor antagonists. A unique and unexpected substitution pattern was ultimately required to maintain reasonable affinity for the CGRP receptor, while at the same time predicting acceptable heterocycle positioning for related analogs. Subsequently, specific quinoline and naphthyridine compounds were prepared which supported these structural predictions by displaying CGRP binding affinities in the 0.037-0.15 nM range.
Bioorganic & Medicinal Chemistry Letters | 2014
June J. Kim; Michael R. Wood; Shawn J. Stachel; Pablo De Leon; Ashley Nomland; Craig A. Stump; Melody Mcwherter; Kathy M. Schirripa; Eric L. Moore; Christopher A. Salvatore; Harold G. Selnick
A new class of CGRP receptor antagonists was identified by replacing the central amide of a previously identified anilide lead structure with ethylene, ethane, or ethyne linkers. (E)-Alkenes as well as alkynes were found to preserve the proper bioactive conformation of the amides, necessary for efficient receptor binding. Further exploration resulted in several potent compounds against CGRP-R with low susceptibility to P-gp mediated efflux.
Archive | 2006
Ian M. Bell; Craig A. Stump; Cory R. Theberge; Michael R. Wood; C. Blair Zartman
Archive | 2007
Michael R. Wood; Ian M. Bell; Steven N. Gallicchio; Harold G. Selnick; Craig A. Stump; C. Blair Zartman
Archive | 2006
Ian M. Bell; Harold G. Selnick; Michael R. Wood; Cory R. Theberge; Craig A. Stump; Steven N. Gallicchio; C. Blair Zartman
Archive | 2004
Michael R. Wood; Neville J. Anthony; Mark G. Bock; Scott D. Kuduk
Archive | 2006
Michael R. Wood; Mark G. Bock; Kathy M. Books; Roger M. Freidinger; June J. Kim
Archive | 2009
Michael R. Wood; Steven N. Gallicchio; Harold G. Selnick; C. Blair Zartman; Ian M. Bell; Craig A. Stump
Archive | 2008
Michael R. Wood; June Kim; Melody Mcwherter; Harold G. Selnick; Kathy M. Schirripa