Michel Paillet

Choix et mise en place d'un contrôle pondéral libératoire au sein d'une unité hospitalière centralisée de préparation des cytotoxiques

A l’hopital, la preparation des cytotoxiques est communement centralisee au sein de la pharmacie a usage interieur. Une telle preparation est validee par une etape finale de liberation engageant la responsabilite du pharmacien. Bien que moins performant pour s’assurer de l’exactitude des doses a preparer, le controle ponderal peut etre une alternative aux methodes spectrales et chromatographiques. Simple, non destructif et facile a integrer dans une chaine de fabrication, il est realisable avant l’etape de dispensation et capable de reveler de grosses derives de dosages. L’etude presentee porte sur le choix d’un procede de pesee, puis tire des enseignements en termes d’avantages et d’inconvenients suite a la mise en place de ce type de controle liberatoire.

[Photodegradation of chlorpromazine, a drug-related adverse event].

The photodegradation of an active substance during treatment is a rare drug-related adverse event which can sometimes have serious consequences. Health professionals must be aware of the specific storage and administration instructions with regard to chlorpromazine and ensure that they are respected.

Résultats et enseignements d’une stratégie innovante de prise en charge des nausées et vomissements chimio-induitsResults and lessons of an innovating chemotherapy-induced nauseas and vomiting management strategy

Current chemotherapy-induced nausea and vomiting management guidelines recommend taking into account the emetogenic potential of the chemotherapy employed as well as individual risk factors to such effects. We performed an interventional prospective study to assess the impact of an innovating therapeutic optimization strategy. The latter combines current guidelines application to a specific consultation in order to individualize the treatment. This study included 170 patients and covered a total of 1,746 days of various chemotherapies. Among these patients, 86.5% never vomited and 53.8% never had any nausea or vomiting. These results seem generally better than the ones found in the literature with all kinds of chemotherapies. Regarding them, we have attempted to highlight the determining criteria for a successful antiemetic treatment.

Résultats et enseignements d’une stratégie innovante de prise en charge des nausées et vomissements chimio-induits

Current chemotherapy-induced nausea and vomiting management guidelines recommend taking into account the emetogenic potential of the chemotherapy employed as well as individual risk factors to such effects. We performed an interventional prospective study to assess the impact of an innovating therapeutic optimization strategy. The latter combines current guidelines application to a specific consultation in order to individualize the treatment. This study included 170 patients and covered a total of 1,746 days of various chemotherapies. Among these patients, 86.5% never vomited and 53.8% never had any nausea or vomiting. These results seem generally better than the ones found in the literature with all kinds of chemotherapies. Regarding them, we have attempted to highlight the determining criteria for a successful antiemetic treatment.