Michio Ichimura | Researchain

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The Journal of Antibiotics | 2008

In Vitro and in Vivo Antitrypanosomal Activitiy of Two Microbial Metabolites, KS-505a and Alazopeptin

Aki Ishiyama; Kazuhiko Otoguro; Miyuki Namatame; Aid Nishihara; Toshiaki Furusawa; Rokuro Masuma; Kazuro Shiomi; Yoko Takahashi; Michio Ichimura; Haruki Yamada; Satoshi Omura

Our on-going screening program to discover new antitrypanosomal antibiotics has been evaluating compounds isolated from soil microorganisms as well as investigating the antibiotic libraries of the Kitasato Institute for Life Sciences and BioFrontier Laboratories of Kyowa Hakko Kogyo Co., Ltd. We have now discovered two compounds, KS-505a and alazopeptin, which exhibit moderate antitrypanosomal characteristics. We report here the in vitro and in vivo antitrypanosomal activities and cytotoxicities of KS-505a and alazopeptin, compared with some commonly-used antitrypanosomal drugs. This is the first report of in vitro and in vivo antitrypanosomal activities of either KS-505a or alazopeptin.

The Journal of Antibiotics | 1990

Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp.

Michio Ichimura; Tatsuhiro Ogawa; Keiichi Takahashi; Eiji Kobayashi; Isao Kawamoto; Tohru Yasuzawa; Isami Takahashi; Hirofumi Nakano

The Journal of Antibiotics | 1988

DUOCARMYCIN A, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES

Isami Takahashi; Keiichi Takahashi; Michio Ichimura; Makoto Morimoto; Kozo Asano; Isao Kawamoto; Fusao Tomita; Hirofumi Nakano

The Journal of Antibiotics | 1991

Duocarmycins, new antitumor antibiotics produced by Streptomyces; producing organisms and improved production.

Michio Ichimura; Tatsuhiro Ogawa; Shigeo Katsumata; Keiichi Takahashi; Isami Takahashi; Hirofumi Nakano

Chemical & Pharmaceutical Bulletin | 1988

STRUCTURES OF DUOCARMYCINS, NOVEL ANTITUMOR ANTIBIOTICS PRODUCED BY STREPTOMYCES SP.

Tohru Yasuzawa; Takao Iida; Kenichi Muroi; Michio Ichimura; Keiichi Takahashi; Hiroshi Sano

Chemical & Pharmaceutical Bulletin | 1995

Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry.

Tohru Yasuzawa; Kenichi Muroi; Michio Ichimura; Isami Takahashi; Tatsuhiro Ogawa; Keiichi Takahashi; Hiroshi Sano; Yutaka Saitoh

The Journal of Antibiotics | 1988

DC89-A1, a new antitumor antibiotic from Streptomyces.

Michio Ichimura; Kenichi Muroi; Kozo Asano; Isao Kawamoto; Fusao Tomita; Makoto Morimoto; Hirofumi Nakano

The Journal of Antibiotics | 1989

New antitumor antibiotics, duocarmycins B1 and B2.

Tatsuhiro Ogawa; Michio Ichimura; Shigeo Katsumata; Makoto Morimoto; Keiichi Takahashi

Archive | 1988

Pyrindamycins A and B and duocarmycin A antibiotics derived from certain streptomyces culture

Hirofumi Nakano; Isami Takahashi; Michio Ichimura; Isao Kawamoto; Kozo Asasno; Fusao Tomita; Hiroshi Sano; Toru Yasuzawa; Makoto Morimoto; Kazuhisa Fujimoto

The Journal of Antibiotics | 1991