Min-Ki Noh

Overexpression of HSP47 in esophageal squamous cell carcinoma: clinical implications and functional analysis

Several biomarkers of esophageal squamous cell carcinoma (ESCC) have been explored to improve the prognosis of this disease. One of these, the 47-kDa heat shock protein (HSP47), has been screened as a potential biomarker by genomic profiling and is known to be overexpressed in some malignant diseases. In this study, we explored the role and evaluated the prognostic value of HSP47 expression in ESCC. The function of this protein was analyzed by assaying proliferation, wound healing, and colony formation in an HSP47-knockdown ESCC line. The prognostic implication of HSP47 expression was analyzed by immunohistochemical staining in 157 surgical specimens. HSP47 expression level and other clinical variables were analyzed using multivariate Cox proportional hazards models. Silencing of the HSP47 gene in the ESCC cell line inhibited cell proliferation and colony formation. HSP47 was highly expressed in ESCC tissue samples, compared with normal esophageal tissues. The level of immunohistochemical staining of HSP47 and pathologic stage were significantly correlated with overall and recurrence-free survival, as shown by multivariate analysis (P = 0.014 and 0.044, respectively). We found that overexpression of HSP47 is associated with poor prognosis in patients with ESCC and that this is consistent with the function of HSP47 in terms of increased cell proliferation and colony formation. These results suggest that HSP47 is a potential prognostic biomarker for ESCC and merits further research for novel diagnostic and therapeutic applications.

Designing of Healthcare Information Network Using IPv6 Cloud Networks

Information networks have emerged a major research area in the interest of healthcare. There are several applications in the R&D field of healthcare. Healthcare Network must ensure the reliability and efficiency because it transfer data of health. We consider distributed cloud systems, which deploy IPv6 and agents that are geographically distributed over a large number of locations in a wide-area network. In this article, we also argue for a healthcare information management model that provides higher-level connectivity and logical network abstraction that are integral parts of wellness applications.

A revised cache allocation algorithm for VoD multicast service

The Internet is replacing the traditional telephone network as the ubiquitous network infrastructure. Internet customers are increasing at an exponential rate and will continue to increase in the near future. Among the various Internet services, IPTV VoD (Video on Demand) service is expected to be one of the most popular services. In general, for deploying streamed video service, it is likely to use proxy by locating it nearby end-users. The use of proxy in on-demand media streaming service can help reduce the server streaming load and reduce the startup delay of media playback due to swift retrieval of beginning portion of media. We had proposed a cache allocation scheme for server-proxy media streaming environment by utilizing the advantage of threshold-based multicast mechanism. However it suffer from a little radical change of threshold value. In this paper, enhanced multicast-based server-proxy on-demand media streaming algorithm to IPTV VoD services is presented from the storage, caching size and bandwidth requirement viewpoints.

A Virtualized Network Model for Wellness Information Technology Research

It occurs the needs of video-conferencing to exchange the know-how between domestic hospitals and medical school. It is the time to study of deducting a new wellness service considering diverse opinions. In this paper, we study the secure transfer of wellness information, especially medical data and for sharing to the network model.

Distributed Network Operations and Management on Future Internet Based on GMOC and DvNOC Federation

Traditional Internet has confronted quite a few problems in terms of network security, scalability, performance, etc., mainly due to the rapid increase of the number of end-users and various new service demands. Therefore, Future Internet researches have been resolving the fundamental weakness of traditional Internet. As a part of Future Internet developments, the federation and management of distributed Future Internet testbeds is becoming the central challenge to support reliable end-to-end researches. Under the fundamental requirements that Future Internet researches and experiments need to be performed over inter-domain networks, countries, and even continents, this paper presents a VFN (Virtual Federated Network) framework that federates and manages the resource information of autonomous distributed networks (ADNs). VFN environment is a common federation interface between ADNs so that the core network resource information can be federated and provided for end users. Also, we will elaborate the experiment results accomplished by the international collaborative works between GMOC (GENI Meta Operations Center) in the US and DvNOC (Distributed virtual Network Operations Center) in Korea based on the proposed federation framework.

Designing a Specific Group Network Measurement on Light Path

Scientific co-work needs not only cut-edge network infrastructures for large-scale networks but also network technologies for high-performance networks. Specific group network is connected several sites over multi-domains It should support dedicated network resources and advanced measurement for collaborative scientists. In this paper, we introduce measurement technologies and apply network measurement framework to specific group over LP (Light Path) network for scientific communities.

Multimedia Network Service Environment Based on Distributed Virtual Network Management

Multimedia applications are generally based on continuous streams such as audios and videos, which are very dependent on time and space constraints. This dependency leads to the requirement of functional services that support processing and communication of the multimedia data in distributed environments. The functional services, therefore, need to acquire media-specific meta-data from the distributed environment in order to provide end-to-end services with proper Quality of Service (QoS) specifications. In this context, it is very important that distributed multimedia applications become network-aware by gathering and utilizing meta datasets from underlying network resources. DvNOC (Distributed virtual Network Operations Center) is originally devised for user-oriented virtual network management based on distributed network resources. In this paper, we have come up with the DvNOC framework adopted for multimedia applications. The proposed multimedia network service environment based on DvNOC incorporates the functionalities of meta-data gathering, sharing, abstracting, federating, etc., which is ultimately capable of having applications and/or end-users aware of the underlying network resource information associated with media-specific attributes.

Virtual research domains management on L2 optical private network

Recent advances inoptical networks lead the advent of service sensitive applications andthe community researches free from the individual research. Sensitive applications and community researches overOptical Private Network (OPN) is required to supportefficient network resource management, intelligent network switching, and sophisticated access control and monitoring. In this paper, we introduce L2 OPN architecture and describe our experience in implementing L2 OPN. Lastly, we address the function and framework ofVirtual Research Domains Management over L2 OPN.

Organizing Virtual Research Groups with Light Path Technology

Advances in network technologies lead not only the advent of new applications but also research form change from the individual research. Research and Development communities for specific cooperative workgroups over LP (Light Path) are required to support dedicated network resources, intelligent network management, and sophisticated access control and monitoring. In this paper, we introduce LP technologies and describe tightly remote cooperative work community, namely VRG (Virtual Research Group). Lastly, we address the function and framework of VRG with LP technologies

Improved fast handover protocol using HMIPv6 based on IEEE 802.16e network

Since the Wibro service realize mobile network on the public, it has been considered that it is not enough to support real time service at vehicular speed. The standard Fast Mobile IPv6 Handover Protocol using HMIPv6 may guarantee seamless service as long as the Mobile Node moves in the same domain MAP however it does not regard fast handover over inter-MAP domain. Thus Macro Mobility Handover in HMIPv6 was proposed to reduce handover latency in inter-MAP domain. But it is still not enough to support real-time service. So we propose an Improved FH- MIPv6 over 802.16e network to reduce the overall handover latency. We embedded Layer 3 handover messages of the FHMIPv6 into the Layer 2 handover messages. So the MN is able to finish overall handover procedure earlier in our scheme. The numerical results show the performance of IFHMIPv6 has improved 32% in comparison with FHMIPv6.