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Minoru Taguchi

Taisho Pharmaceutical Co.

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Publication

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Bioorganic & Medicinal Chemistry Letters | 2003

Sphingomyelin analogues as inhibitors of sphingomyelinase.

Minoru Taguchi; Kikuo Sugimoto; Kenichi Goda; Tomoko Akama; Kyoko Yamamoto; Taizo Suzuki; Yasumitsu Tomishima; Mariko Nishiguchi; Koshi Arai; Kenzo Takahashi; Takeo Kobori

To search for neutral sphingomyelinase inhibitors we designed and synthesized hydrolytically stable analogues of sphingomyelin. The novel compounds 8 and 9 which were replaced the phosphodiester moiety of sphingomyelin with the carbamate moiety showed inhibitory activity with an IC(50) value of micro M on neutral sphingomyelinase in rat brain microsomes. Compound 8i showed a selective neutral sphingomyelinase inhibitory activity.

Bioorganic & Medicinal Chemistry Letters | 2003

Biological evaluation of sphingomyelin analogues as inhibitors of sphingomyelinase.

Minoru Taguchi; Kenichi Goda; Kikuo Sugimoto; Tomoko Akama; Kyoko Yamamoto; Taizo Suzuki; Yasumitsu Tomishima; Mariko Nishiguchi; Koshi Arai; Kenzo Takahashi; Takeo Kobori

Chemical & Pharmaceutical Bulletin | 1995

Synthesis and Pharmacological Evaluation of 1, 2, 3, 4-Tetrahydro-β-carboline Derivatives

Yutaka Kawashima; Akiyo Horiguchi; Minoru Taguchi; Yoshimi Tuyuki; Yasuko Karasawa; Hiroaki Araki; Katsuo Hatayama

Archive | 1992

Thienopyrimidin-4-one derivative

Minoru Taguchi; Tomomi Ota; Katsuo Hatayama

Archive | 1998

2-phenoxyaniline derivatives

Tomomi Ota; Misa Taisho Pharmace Nakanishi; Minoru Taguchi; Kazuyuki Tomisawa

Chemical & Pharmaceutical Bulletin | 1990

Studies on Topical Antiinflammatory Agents. V. : 17-(Alkylthio)- and Methoxyalkanoates of Corticosteroids

Morihiro Mitsukuchi; Tomoyuki Ikemoto; Minoru Taguchi; Shohei Higuchi; Satoshi Abe; Hajime Yasui; Katsuo Hatayama

Chemical & Pharmaceutical Bulletin | 1989

Studis on Topical Antiinflammatory Agents. III. : Synthesis of 17α-Acyloxy-9α-fluoro-11β-hydroxy-16β-methyl-1, 4-pregnadiene-3, 20-dione 21-Thio Dericatives and Related Compounds

Morihiro Mitsukuchi; Tomoyuki Ikemoto; Minoru Taguchi; Shohei Higuchi; Satoshi Abe; Hajime Yasui; Katsuo Hatayama; Kaoru Sota

Archive | 2000

Derivative of sphingosine

Kenichi Aida; Takeo Kobori; Kikuo Sugimoto; Minoru Taguchi; 賢一 合田; 武夫 小堀; 貴久男 杉本; 稔 田口

Chemical & Pharmaceutical Bulletin | 1989

Studies on topical antiinflammatory agents. II. Synthesis and vasoconstrictive activity of 21-substituted corticosteroids with sulfur-containing moieties.

Morihiro Mitsukuchi; Tomoyuki Ikemoto; Minoru Taguchi; Shohei Higuchi; Satoshi Abe; Hajime Yasui; Katsuo Hatayama; Kaoru Sota

Chemical & Pharmaceutical Bulletin | 1990

Studies on Topical Antiinflammatory Agents. IV., : 21-(Alkylthio)acetates and (Methylthio)methoxides of Corticosteroids

Morihiro Mitsukuchi; Tomoyuki Ikemoto; Minoru Taguchi; Shohei Higuchi; Satoshi Abe; Hajime Yasui; Katsuo Hatayama

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Collaboration

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Katsuo Hatayama

Taisho Pharmaceutical Co.

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Morihiro Mitsukuchi

Taisho Pharmaceutical Co.

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Tomoyuki Ikemoto

Taisho Pharmaceutical Co.

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Kaoru Sota

Taisho Pharmaceutical Co.

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Tomomi Ota

Taisho Pharmaceutical Co.

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Hajime Yasui

Taisho Pharmaceutical Co.

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Satoshi Abe

Taisho Pharmaceutical Co.

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Shohei Higuchi

Taisho Pharmaceutical Co.

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Takeo Kobori

Taisho Pharmaceutical Co.

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Kikuo Sugimoto

FMC Corporation

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