Mirja Van Holderbeke

Long-term consequences of non-intentional flows of substances: Modelling non-intentional flows of lead in the Dutch economic system and evaluating their environmental consequences

Substances may enter the economy and the environment through both intentional and non-intentional flows. These non-intentional flows, including the occurrence of substances as pollutants in mixed primary resources (metal ores, phosphate ores and fossil fuels) and their presence in re-used waste streams from intentional use may have environmental and economic consequences in terms of pollution and resource availability. On the one hand, these non-intentional flows may cause pollution problems. On the other hand, these flows have the potential to be a secondary source of substances. This article aims to quantify and model the non-intentional flows of lead, to evaluate their long-term environmental consequences, and compare these consequences to those of the intentional flows of lead. To meet this goal, the model combines all the sources of non-intentional flows of lead within one model, which also includes the intentional flows. Application of the model shows that the non-intentional flows of lead related to waste streams associated with intentional use are decreasing over time, due to the increased attention given to waste management. However, as contaminants in mixed primary resources application, lead flows are increasing as demand for these applications is increasing.

Determination of contamination pathways of phthalates in food products sold on the Belgian market

As numerous studies have indicated that food ingestion is the most important exposure pathway to several phthalates, this study aimed to determine possible contamination pathways of phthalates in food products sold on the Belgian market. To do this, concentrations of eight phthalates (dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), benzylbutyl phthalate (BBP), dicyclohexyl phthalate (DCHP), di(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DnOP)) were determined in 591 foods and 30 packaging materials. In general, the four most prominent phthalates in Belgian food products were DEHP, DiBP, DnBP and BBP. Special attention was given to the origin of these phthalates in bread, since high phthalate concentrations (especially DEHP) were determined in this frequently consumed food product. Phthalates seemed to occur in Belgian bread samples due to the use of contaminated ingredients (i.e. use of contaminated flour) as well as due to migration from phthalate containing contact materials used during production (e.g. coated baking trays). Also the results of the conducted concentration profiles of apple, bread, salami and two cheese types revealed the important role of processing - and not packaging - on phthalate contents in foods.

Assessing multimedia/multipathway exposures to inorganic arsenic at population and individual level using MERLIN-Expo

In this study, we report on model simulations performed using the newly developed exposure tool, MERLIN-Expo, in order to assess inorganic arsenic (iAs) exposure to adults resulting from past emissions by non-ferrous smelters in Belgium (Northern Campine area). Exposure scenarios were constructed to estimate external iAs exposure as well as the toxicologically relevant As (tAs, i.e., iAs, MMA and DMA) body burden in adults living in the vicinity of the former industrial sites as compared to adults living in adjacent areas and a reference area. Two scenarios are discussed: a first scenario studying exposure to iAs at the aggregated population level and a second scenario studying exposure at the individual level for a random sub-sample of subjects in each of the three different study areas. These two scenarios only differ in the type of human related input data (i.e., time-activity data, ingestion rates and consumption patterns) that were used, namely averages (incl. probability density functions, PDFs) in the simulation at population level and subject-specific values in the simulation at individual level. The model predictions are shown to be lower than the corresponding biomonitoring data from the monitoring campaign. Urinary tAs levels in adults, irrespective of the area they lived in, were under-predicted by MERLIN-Expo by 40% on average. The model predictions for individual adults, by contrast, under-predict the biomonitoring data by 7% on average, but with more important under-predictions for subjects at the upper end of exposure. Still, average predicted urinary tAs levels from the simulations at population level and at individual level overlap, and, at least for the current case, lead to similar conclusions. These results constitute a first and partial verification of the model performance of MERLIN-Expo when dealing with iAs in a complex site-specific exposure scenario, and demonstrate the robustness of the modelling tool for these situations.

Integrated Chain Management by Applying Substance Flow Analysis in the Flemish Region of Belgium

Abstract Substance flow analysis is an analytical tool in the scientific field of industrial ecology, a possible operationalisation of the concept of industrial metabolism. 1 In this concept, an analogy is drawn between the economy and environment on a material level: the economys “metabolism”, in terms of materials mobilisation, use and excretion to create “technomass”, is compared to the use of materials in the biosphere to create biomass. The economy is viewed only in terms of its material flow. The policy area most closely related to this concept is integrated chain management. Economic chains from cradle to grave are the subjects of regulation. This paper presents the implementation of substance flow analysis in the Flemish region of Belgium. In Belgium, there exists up to now relatively little or no experience with the use of substance flow analysis. In this context, the Flemish Government, more specific the competent Flemish minister for the Science and technological innovation policy supported a project regarding substance flow analysis on heavy metals.

Key aspects of a Flemish system to safeguard public health interests in case of chemical release incidents.

Although well-established protocols are available for emergency services and first-responders in case of chemical release incidents, a well-developed system to monitor and safeguard public health was, until recently, lacking in Flanders. We therefore developed a decision support system (DSS) to aid public health officials in identifying the appropriate actions in case of incidents. Although the DSS includes human biomonitoring as one of its key instruments, it also goes well beyond this instrument alone. Also other, complementary, approaches that focus more on effect assessment using in vitro toxicity testing, indirect exposures through the food chain, and parallel means of data collection (e.g. through ecosurveillance or public consultation), are integrated in the Flemish approach. Even though the DSS is set up to provide a flexible and structured decision tree, the value of expert opinion is deemed essential to account for the many uncertainties associated with the early phases of technological incidents. When the DSS and the associated instruments will be fully operational, it will provide a valuable addition to the already available protocols, and will specifically safeguard public health interests.

Phthalates in food on the Belgian market: occurrence and possible contamination pathways

Phthalates are organic lipophilic compounds which are mainly used as plasticizer in plastic polymers. Human exposure occurs mainly via food intake and can cause a wide range of negative health effects. Phthalates are not only present in food because of environmental contamination, but also as a result of migration from contact materials. This study investigated phthalates in cow milk in order to determine the contamination pathways at farm level. The levels of eight phthalates were determined in raw milk samples collected during summer and winter at five farms located in ‘The Kempen’ (Belgium). Both manually obtained milk samples as milk samples milked by machine were collected. Analysis was performed by gas chromatography-mass spectrometry. The analysis of the milk samples milked by machine revealed a difference in average total phthalate level between the summer and the winter sampling period (572 versus 379 µg/kg fat). While the total phthalate levels of the different farms during winter were nearly of similar magnitude (291-587 µg/kg fat), a wide range could be observed during summer (95-1550 µg/kg fat). Comparing milk samples within a farm, lower total phthalate levels were found in the milk samples milked by hand than those by machine (100 versus 179 µg/kg fat). Di(2-ethylhexyl) phthalate which is the most commonly used plasticizer worldwide, was the most dominating one (79 % of the total concentration in milk from the central collecting tank). The results indicate that the contamination pathways for phthalates in cow milk vary across seasons. An explanation therefore is that the feed composition is different during summer than during winter. In summer, cows are grazing in the fields where an extra phthalate contamination can occur via soil ingestion. Comparing the milk samples milked by hand with those by machine reveals that the milking equipment is another important contamination pathway.The International Society for Environmental Epidemiology (ISEE) is an international organization with almost 1000 members from more than 60 countries. The annual international conference brings together many members and non-members and provides an excellent forum for the discussion of problems and benefits related to the environment and human health. Specific themes for the 23rd Annual Conference include: Sustainable transport and health: Impact of transport on health and approaches to reduce health impacts, Impact of climate change: from water scarcity to Saharan dust episodes, Early exposure - later life: in utero and early life exposures and effects in later life, New methods and technologies.Background and Aims: Phthalates are used in many industrial and consumer products. High-molecular-weight phthalates are primarily used as plasticizers to soften PVC products, while low-molecular-weight phthalates are widely used as solvents to hold colour and scent in products. Phthalates have been detected in food and also measured in humans. This study investigated phthalates in food products on the Belgian market in order to explore possible contamination pathways. Methods: 650 Representative samples of widely consumed foods were purchased in Belgian shops. The levels of eight phthalates were determined and product specific properties were stored in a database. This database was used to explore the contamination pathways by identifying relations between sample properties (e.g. fat content, pH and packaging) and measured phthalate concentrations. Results: The results of the measurement campaign show a wide variety of phthalate concentrations in the food samples. Concentrations are higher in high-fat food products like butter, oil and cheese compared to low-fat food products, like vegetables and juices. Higher phthalate concentrations were also detected in some cardboard packed food, probably due to migration from inks and glues. Aluminium inner package seems to be a good barrier for migration. A wide range of phthalate levels in bread was found and further research is necessary. Conclusions: A wide variety in phthalate concentration was found. The fat content of the food product, the composition of the food as well as the composition and properties of the packaging material have been identified as possible contamination causing conditions. In a next phase of this study, we will use these data to quantify the dietary intake of phthalates for the Belgian population.

Phthalates in cow milk: possible contamination pathways at farm level

Phthalates are organic lipophilic compounds which are mainly used as plasticizer in plastic polymers. Human exposure occurs mainly via food intake and can cause a wide range of negative health effects. Phthalates are not only present in food because of environmental contamination, but also as a result of migration from contact materials. This study investigated phthalates in cow milk in order to determine the contamination pathways at farm level. The levels of eight phthalates were determined in raw milk samples collected during summer and winter at five farms located in ‘The Kempen’ (Belgium). Both manually obtained milk samples as milk samples milked by machine were collected. Analysis was performed by gas chromatography-mass spectrometry. The analysis of the milk samples milked by machine revealed a difference in average total phthalate level between the summer and the winter sampling period (572 versus 379 µg/kg fat). While the total phthalate levels of the different farms during winter were nearly of similar magnitude (291-587 µg/kg fat), a wide range could be observed during summer (95-1550 µg/kg fat). Comparing milk samples within a farm, lower total phthalate levels were found in the milk samples milked by hand than those by machine (100 versus 179 µg/kg fat). Di(2-ethylhexyl) phthalate which is the most commonly used plasticizer worldwide, was the most dominating one (79 % of the total concentration in milk from the central collecting tank). The results indicate that the contamination pathways for phthalates in cow milk vary across seasons. An explanation therefore is that the feed composition is different during summer than during winter. In summer, cows are grazing in the fields where an extra phthalate contamination can occur via soil ingestion. Comparing the milk samples milked by hand with those by machine reveals that the milking equipment is another important contamination pathway.The International Society for Environmental Epidemiology (ISEE) is an international organization with almost 1000 members from more than 60 countries. The annual international conference brings together many members and non-members and provides an excellent forum for the discussion of problems and benefits related to the environment and human health. Specific themes for the 23rd Annual Conference include: Sustainable transport and health: Impact of transport on health and approaches to reduce health impacts, Impact of climate change: from water scarcity to Saharan dust episodes, Early exposure - later life: in utero and early life exposures and effects in later life, New methods and technologies.Background and Aims: Phthalates are used in many industrial and consumer products. High-molecular-weight phthalates are primarily used as plasticizers to soften PVC products, while low-molecular-weight phthalates are widely used as solvents to hold colour and scent in products. Phthalates have been detected in food and also measured in humans. This study investigated phthalates in food products on the Belgian market in order to explore possible contamination pathways. Methods: 650 Representative samples of widely consumed foods were purchased in Belgian shops. The levels of eight phthalates were determined and product specific properties were stored in a database. This database was used to explore the contamination pathways by identifying relations between sample properties (e.g. fat content, pH and packaging) and measured phthalate concentrations. Results: The results of the measurement campaign show a wide variety of phthalate concentrations in the food samples. Concentrations are higher in high-fat food products like butter, oil and cheese compared to low-fat food products, like vegetables and juices. Higher phthalate concentrations were also detected in some cardboard packed food, probably due to migration from inks and glues. Aluminium inner package seems to be a good barrier for migration. A wide range of phthalate levels in bread was found and further research is necessary. Conclusions: A wide variety in phthalate concentration was found. The fat content of the food product, the composition of the food as well as the composition and properties of the packaging material have been identified as possible contamination causing conditions. In a next phase of this study, we will use these data to quantify the dietary intake of phthalates for the Belgian population.

Modeling Human Exposure to Cadmium and Arsenic in a Zinc Smelter Area-A Belgian Case Study

[Standaert, Arnout; Van Holderbeke, Mirja; Cornelis, Christa; Van Deun, Jeroen; Torfs, Rudi] VITO Flemish Inst Technol Res, Mol, Belgium. [Van Campenhout, Karen] Flemish Govt, Environm Nat & Engergy Dept, Mechelen, Belgium. [Van Gestel, Griet] OVAM Publ Waste Agcy Flanders, Mechelen, Belgium. [Wildemeersch, Dirk] Flemish Govt, Flemish Agcy Care & Hlth, Brussels, Belgium. [Nelen, Vera] PIH Prov Inst Hyg, Antwerp, Belgium. [Bruckers, Liesbeth] Univ Hasselt, Hasselt, Belgium.