Misun Kim

Effects of the nitric oxide releasing biomimetic nanomatrix gel on pulp-dentin regeneration: Pilot study

Successful disinfection alongside complete endodontic tissue regeneration and revascularization are the most desired clinical outcomes of regenerative endodontics. Despite reported clinical successes, significant limitations to the current regenerative endodontic procedure (REP) have been elucidated. To improve the current REP, an antibiotics and nitric oxide (NO) releasing biomimetic nanomatrix gel was developed. The study evaluates antibacterial effects of an antibiotics and NO releasing biomimetic nanomatrix gel on multispecies endodontic bacteria. Antibiotics, ciprofloxacin (CF) and metronidazole (MN) were mixed and encapsulated within the NO releasing biomimetic nanomatrix gel. The gel was synthesized and self-assembled from peptide amphiphiles containing various functional groups. Antibacterial effects of the antibiotics and NO releasing biomimetic nanomatrix gel were evaluated using bacterial viability assays involving endodontic microorganisms including clinical samples. Pulp-dentin regeneration was evaluated via animal-model experiments. The antibiotics and NO releasing biomimetic nanomatrix gel demonstrated a concentration dependent antibacterial effect. In addition, NO alone demonstrated a concentration dependent antibacterial effect on endodontic microorganism. An in vivo analysis demonstrated the antibiotics and NO releasing biomimetic nanomatrix gel promoted tooth revascularization with maturation of root canals. An optimal concentration of and NO releasing nanomatrix gel is suggested for its potential as a root treatment material for REP and an appropriate protocol for human trials. Further investigation is required to obtain a larger sample size and decide upon ideal growth factor incorporation.

A Survey of Guardian’s Attitudes toward Behavior Guidance Techniques

본 연구의 목적은 국내 실정에 맞는 행동유도법에 대한 보호자의 인식도를 조사하여 어린이 환자와 보호자, 그리고 치과 의사간의 긍정적인 관계를 설정하는데 기초 자료를 제공하는 것이다. 117명의 보호자에게 소아치과에서 사용되는 행동유도법에 대해 구두로 설명한 후 설문지를 작성하게 하였다. 설문지에 포함된 행동...

Three Dimensional Analysis of Primary Maxillary Central and Lateral Anterior Zirconia Crown

This study was performed to compare the shape and dimension of anterior zirconia crowns to other pediatric crowns using a three-dimensional scanner to investigate adequate amount of tooth preparation. Primary central and lateral anterior zirconia crowns, stainless steel crowns and celluloid strip crowns were scanned by a three-dimensional scanner. Outer and inner surfaces of zirconia and stainless steel crowns, and outer surface of celluloid strip crowns were analyzed. In outer scanned images, all sizes of central and lateral size 1 zirconia crown had the largest labiolingual diameter among the three crowns. In inner scanned images, zirconia crown`s mesiodistal diameter was 0.7-1.0 mm smaller and crown length was approximately 1 mm shorter than those of stainless steel crowns. Zirconia crown`s labiolingual diameter was larger in central crowns whereas it was smaller in lateral crowns than that of stainless steel crowns. Recommended preparation required for zirconia crown is incisal 2.5-3.0 mm, mesiodistal 1.5-2.0 mm, labial 0.5-1.0 mm. Cingulum should be trimmed parallel to the long axis. No more lingual reduction is needed in central incisors whereas additional 0.5 mm reduction is suggested in lateral incisors.

Analysis of 269 Cases of Jaw Cysts in Children and Adolescents: A Retrospective Study over a Decade

This study aimed to identify the characteristics of jaw cysts among children and adolescents treated at the Kyung Hee University Dental Hospital from 2005 to 2015. A retrospective observational study was conducted of 269 jaw cysts diagnosed in 253 patients. The following variables were recorded: gender, age, prevalence and location of lesions, clinical symptoms and treatment. Statistical analyses were performed using the SPSS (version 20.0). Our results suggest that the cysts are slightly more prevalent in males. Cystic lesions of the jaws in children are predominantly odontogenic and developmental in origin. Dentigerous cysts predominate in developmental cysts and the most frequent diagnosis is radicular cysts in inflammation cysts. The most common location of the cysts is in the mandible, particularly the lower molar region. In numerous cases, the patients have no clinical symptoms. Most cysts were surgically enucleated with tooth extraction. Furthermore, our findings demonstrate that the characteristics of jaw cysts in children are distinctive and differ in several respects from the corresponding distribution of jaw cysts in adult population. Therefore, knowledge of the clinical, radiological and histopathological behavior of jaw cysts and periodic radiographic examination are key factors for early diagnosis and adequate treatment of jaw cysts in children.

Comparison of Dental Outcomes after General Anesthesia According to the Follow-up Pattern in Special Health Care Needs Patients

Special Health Care Needs (SHCN) patients need regular follow-up because of high incidence and severity of oral disease. The aim of this study was to evaluate the dental treatment outcomes of SHCN patients according to follow-up patterns. SHCN patients who were treated under general anesthesia (GA) at Kyung Hee University Dental Hospital from 2006 to 2014 were included in this study. The final samples comprised of 53 patients that were divided into regular (33 patients) and irregular (20 patients) follow-up groups according to their follow-up patterns. The type of dental treatment after GA during the follow-up periods were compared. In the irregular group, aggressive treatment including endodontic, prosthetic treatment, and extraction were predominant, compared with the regular group (p

Predictive Factors of Ectopic Eruption of the Maxillary First Permanent Molar

In order to provide a diagnostic basis for predicting the possibility of the self-correction of ectopic first permanent molars, differences among normal eruption, reversible and irreversible ectopic eruption of maxillary first permanent molars were retrospectively analyzed. The angles of the long axes and the occlusal lines between the maxillary first permanent molar and the adjacent tooth were measured by panoramic radiographs. The occlusal relationship of second primary molars was also investigated. There is a statistically significant difference between the ectopic eruption group and normal group (p < 0.05), but not between the reversible and irreversible ectopic eruption groups (p > 0.05). The angles between the second primary molar and the first permanent molar, the second primary molar and the second permanent molar in ectopic groups showed a smaller degree than those of the control group. Mesial step was found more frequently in the ectopic eruption group than the normal group. In conclusion, the angulation of the first permanent molar and tooth germ of the maxillary second permanent molar showed close relation with ectopic eruption of the maxillary first permanent molar and ectopic first permanent molar is likely to occur in class III patients with maxillary deficiency.

Management of Premature Loss of Primary Molars with Flexible Denture

Early loss of a primary second molar can cause mesial drift or tilting of the permanent first molar. We present a case of the early loss of the mandibular primary molars in a 5-year-old girl. The patient required extraction of the mandibular left primary first and second molars due to folliculitis on the successors. A flexible denture was used for eruption guidance of the permanent first molar and the recovery of masticatory function simultaneously.