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Featured researches published by Mithat Oner.


Phytotherapy Research | 2011

Effects of Propolis on Fracture Healing: An Experimental Study

Ahmet Guney; Ibrahim Karaman; Mithat Oner; Mükerrem Betül Yerer

Propolis is a substance of honeybee origin with known antioxidant effects. The purpose of this study was to examine the effects of propolis on fracture healing and the antioxidant system in an experimental setting. Thirty‐two rats that underwent experimental femur fracture and then fixation were randomly allocated in one of four groups: two control groups (Control‐3w and Control‐6w) and two treatment groups (Propolis‐3w and Propolis‐6w). Treatment groups received propolis until killing (at 3 or 6 weeks). X‐ray, histological, bone mineral density measurement findings and endogenous antioxidant levels were examined. The bone mineral density was higher, radiological and histological evaluation scores were better, and superoxide dismutase, total glutathione and myeloperoxidase levels were lower among the rats that received oral propolis treatment compared with the controls. In addition, bone mineral density and histological assessment scores showed time‐dependent improvement in the treatment group. In conclusion, the findings of this study suggest that propolis has some time‐dependent beneficial effects on fracture healing. Copyright


Experimental and Clinical Endocrinology & Diabetes | 2015

Biomechanical properties of Achilles tendon in diabetic vs. non-diabetic patients.

Ahmet Guney; F. Vatansever; Ibrahim Karaman; Ibrahim Halil Kafadar; Mithat Oner; Cemil Yildirim Turk

BACKGROUND/OBJECTIVES Structural and functional impairments of the Achilles tendon in diabetic patients has the potential to contribute to ulcer formation through altered foot mechanics. This study aimed to examine the biomechanical and histopathological alterations in Achilles tendon specimens from diabetic vs. non-diabetic individuals. MATERIALS AND METHODS 42 Achilles tendon samples obtained from patients treated with below-knee or above-knee amputation for chronic diabetic foot ulcers (n=21) or for non-diabetic conditions (n=21) were included. A tensile test was performed for each tendon and a stress vs. strain graft was obtained to calculate following biomechanical parameters: elasticity (Young modulus), load, stiffness, toughness, energy, strain, elongation and tenacity. Groups were also compared with regard to histopathological findings (inflammatory cell infiltration, collagen organization, and degeneration). RESULTS Non-diabetic tendons exhibited a superior biomechanical profile over diabetic tendons with regard to the following biochemical parameters: elasticity, maximum load, stiffness, toughness, load, energy, strain and elongation at break point, tenacity, and strain at automatic load drop (p<0.05 for all comparisons). Diabetic tendons had mild impairment of collagen organization and focal collagen degeneration, whereas neither diabetic nor non-diabetic tendons had inflammatory cell infiltration. CONCLUSION The structural and functional alterations associated with diabetes adversely affect the biomechanical properties of the Achilles tendon, potentially acting together with neuropathy and ischemia in the development of diabetic foot ulcers.


Journal of Pediatric Orthopaedics B | 2014

Mid-term results of the elastic intramedullary nailing in paediatric long bone shaft fractures: a prospective study of 102 cases.

Ibrahim Karaman; Mehmet Gökhan Halici; Ibrahim Halil Kafadar; Ahmet Guney; Mithat Oner; Kağan Gurbuz; Zehra Filiz Karaman

The aim of this study was to evaluate the mid-term results of a large series of paediatric patients with long bone shaft fractures who were treated with elastic intramedullary nailing. Between November 2009 and November 2010, 108 long bone shaft fractures in 102 patients were treated with elastic intramedullary nails. The number of nails used, admission time, nail diameter/medullary canal diameter ratio of the nontraumatized extremity, weeks until radiological consolidation, weeks until full weight bearing for the femur and tibia shaft fractures, weeks until the nails were removed, number of radiographs from the diagnosis time to the removal time of nail(s), clinical complications and radiological results were recorded; the union rate, time to union, nonunion, delayed union, malrotation, malalignment, follow-up time and functional outcomes (Flynn outcome scoring) were also recorded. The mean follow-up time was 22.2 (14–30) months. The mean age of the patients was 9.6 (6–15) years for all cases. The mean nail removal time for all cases was 19.2 (17–29) weeks. Eighteen patients developed complications: six had insufficient reductions; two had refractures; four developed a deep infection; one had delayed union that needed revision; two had lower extremity length discrepancies of more than 15 mm; and three had skin impingements. The mean admission time was 19 (6–32) h; the mean number of radiographs from the diagnosis time to the removal time of nail(s) was 14 (8–20) for each fracture. All patients showed excellent or satisfactory results according to Flynn’s criteria. The mean time to full weight bearing for the femur and tibia shaft fractures was 62.4 (52–88) days. A nail diameter/medullary canal diameter ratio of over 0.4 showed good results; short union time, less lower extremity length discrepancy and less malalignment were recorded. When patients were informed about possible complications as well as the advantages, almost all chose the operative approach. According to our experience and opinion, elastic intramedullary nailing is the best choice for diaphyseal fractures in children with skeletal immaturity compared with other surgical choices such as osteosynthesis with a plate.


Current Eye Research | 2006

Color Doppler Imaging of Ocular Hemodynamic Changes in Behçet Disease and Uveitis Patients with Different Etiologies

Ayse Oner; Ali Akal; Nuri Erdogan; Hakki Dogan; Mithat Oner

Purpose: To investigate blood flow velocity changes and resistivity index values of orbital vessels in Behçet disease with or without ocular involvement, in uveitis patients with different etiologies, and in healthy volunteers. Methods: Subjects were divided into four groups: those with ocular involvement in Behçet disease (group I), those without ocular involvement in Behçet disease (group II), uveitis patients with different etiologies (group III), and a control group (group IV). Twenty-seven eyes in group I, 14 eyes in group II, 25 eyes in group III, and 27 eyes in group IV were investigated. The blood flow in the central retinal artery (CRA), ophthalmic artery (OA), nasal posterior ciliary artery (NPCA), and the temporal posterior ciliary artery (TPCA) was measured using color Doppler ultrasonography (CDU) to determine the peak systolic velocity (PSV), end diastolic velocity (EDV), and resistivity index (RI). Results: The PSV and EDV value of CRA in groups I, II, and III were found to be significantly lower than those in the control group (p < 0.05 for each). The PSV and EDV values of TPCA and NPCA in groups I, II, and III were significantly lower than those in the control group (p < 0.05 for each). Resistivity indexes of all arteries were higher in groups I, II, and III than the control group. The PSV and EDV in CRA, TPCA, and NPCA in Behçet disease patients with ocular involvement were significantly lower than all other groups (p < 0.05). Conclusions: There are significant reductions in the blood flow values of the orbital arteries in patients with Behçet disease and uveitis patients with different etiologies when compared with healthy volunteers. The decrease in blood flow values in Behçet disease is more evident in patients with ocular involvement than the patients without ocular involvement. This might be the result of occlusive vasculitis, which is frequently seen in the retinal vessels of patients with Behçet disease.


Journal of Pediatric Orthopaedics B | 2013

Intrapelvic pin migration after Salter innominate osteotomy and laparoscopic removal: a case report.

Ibrahim Karaman; Ibrahim Halil Kafadar; Mithat Oner; Mehmet Gökhan Halici

Although there are many methods for the treatment of developmental dysplasia of the hip, Salter innominate osteotomy is a surgical technique presently used successfully worldwide. However, several complications can be found after Salter innominate osteotomy. Kirschner (K) wire migration into the pelvic cavity is not a common occurrence and is also rarely reported in the literature. Here, we report the case of a patient who was admitted to the emergency department of our hospital with acute abdominal pain because of K wire migration into the pelvis. We recommend bending the proximal end of the K wires or using threaded K wires to prevent this complication.


Acta Orthopaedica et Traumatologica Turcica | 2014

Comparison of simultaneous bilateral with unilateral total knee arthroplasty

Yakup Ekinci; Mithat Oner; Ibrahim Karaman; Ibrahim Halil Kafadar; Mahmut Mutlu; Mahmut Argun

OBJECTIVE The aim of this study was to compare simultaneous bilateral total knee arthroplasty (BTKA) and unilateral total knee arthroplasty (UTKA) in terms of morbidity, clinical and radiological findings and quality of life. METHODS The study included 48 simultaneous BTKAs (46 females, 2 males; mean age: 64.00 ± 8.31 years) and 53 UTKAs (46 females, 7 males; mean age: 64.40 ± 7.45 years) performed between November 2007 and June 2012. Groups were compared with respect to comorbidity, complications, blood transfusion, hospital stay, clinical and radiological (American Knee Society Score) findings and quality of life (SF-36). RESULTS Three patients in the BTKA group and 1 in the UTKA group required intensive care admission due to pulmonary embolism; 2 cases occurred within the first postoperative 30 days. One BTKA patient died in the early postoperative period and 1 patient from the BTKA and 1 from the UTKA group died within 1 year. Hospital stay, perioperative blood transfusion parameters and mortality rates were significantly different in favor of UTKA and revision operation rates in favor of BTKA (p<0.05). All patients had improved knee and function scores and SF-36 scores. However, there was no significant difference between the groups (p>0.05). CONCLUSION Simultaneous BTKA should be considered in selected patients under 70 years of age with good compliance and no comorbid disease.


Acta Orthopaedica et Traumatologica Turcica | 2014

The effects of locally applied simvastatin on an experimental mouse femur nonunion model

Atilla Koçer; Mithat Oner; Ibrahim Karaman; Derya Koçer; Ibrahim Halil Kafadar; Ahmet Guney; Zehra Filiz Karaman

OBJECTIVE The aim of this study was to assess the effects of locally applied simvastatin on femur nonunions in a mouse model. METHODS The study included 32 male Wistar albino mice randomly allocated to one of four groups: two control groups (control-4 week [C4w] and control-8 week (C8w)] and two treatment groups (simvastatin-4 week [S4w] and simvastatin-8 week [S8w]). The control groups received dimethylsulfoxide locally injected at a dose of 10 mg/kg/day after surgical intervention for 1 week. Treatment groups received a liquefied form of simvastatin locally to the osteotomy field by injection at a dose of 10 mg/kg/day, starting from the first postoperative day for 1 week. The C4w and S4w groups were sacrificed 4 weeks and the C8w and S8w groups 8 weeks after the end of local treatment. Before sacrifice, intracardiac blood samples were retrieved for biochemical analysis and radiographies were taken. The right femurs of mice were then removed for histopathological evaluation. RESULTS There were significant differences between the control and treatment groups when evaluated radiologically. Significantly higher levels of bone-specific alkaline phosphatase and osteocalcin values were found in the treatment groups than in the controls (p<0.05). CONCLUSION According to biochemical, radiological and histopathological results, local application of simvastatin appears to produce beneficial effects on the mouse femur nonunion model.


Annals of Plastic Surgery | 2010

Biomechanical properties of a new multilocking loop peripheral suture technique for the repair of flexor tendons: a comparative experimental study.

Yildirim Turk; Ahmet Guney; Mithat Oner; Mehmet Gökhan Halici

We aimed to evaluate the biomechanical properties of a new multilocking loop peripheral suture technique. For this aim, 40-deep digital flexor tendons of adult male sheep front limb were divided and then repaired using one of the following methods: simple peripheral suture plus 2- or 4-strand Kessler core suture or a new multilocking loop peripheral suture combined with either 2- or 4-strand Kessler core suture. Intact tendons were used as controls. The following biomechanical parameters were tested: ultimate tensile strength, energy to failure, 2-mm gap formation force, stiffness, and mechanism of failure. Regardless of the number of core suture strands, the new technique resulted in greater ultimate tensile strength, energy to failure, 2-mm gap formation force, and stiffness values, compared with simple running peripheral suture. In conclusion, the new multilocking loop peripheral suture technique represents a biomechanically strong and technically suitable method for flexor tendon repair.


Current Therapeutic Research-clinical and Experimental | 2013

Fondaparınux Versus Nadroparın for Preventıon of Venous Thromboembolısm After Electıve Hıp and Knee Arthroplasty

Mahmut Argun; Mithat Oner; Mehmet Saglamoglu; Ibrahim Karaman; Ahmet Guney; Mehmet Gökhan Halici; Ibrahim Halil Kafadar

Objective To evaluate the efficacy and safety of fondaparinux compared with nadroparin for prevention of venous thromboembolism after arthroplasty. Patients and methods One hundred fifteen patients were randomized into 2 treatment groups. Patients were given fondaparinux in Group I and nadroparin in Group II. Measurements were performed on Days 1, 5, and 21. The wound area was assessed with a subjective visual analog scale. Results The blood counts, clinical biochemical tests, and coagulation tests (ie, thrombin time, partial thromboplastin time, activated partial thromboplastin time, fibrinogen, prothrombin time–International Normalized Ratio, and antithrombin III activity) did not show statistically significant differences between Group I and Group II. In both study groups, anti-factor Xa activities increased significantly on the fifth and 21st day. The scores of the subjective visual analog scale showed significance on Day 21. Conclusions Our results confirm the safety and efficacy of both fondaparinux and nadroparin for prophylaxis after major orthopedic surgery.


Journal of Pediatric Orthopaedics B | 2011

Effect of intraarticular propolis in an experimental septic arthritis model.

Mithat Oner; Ibrahim Halil Kafadar; Ahmet Guney; Mehmet Gökhan Halici; Kemal Deniz; Yildirim Turk; Mahmut Argun

To evaluate the efficacy and safety of intraarticular propolis compared with systemic antibiotic treatment in an experimental septic arthritis model. Thirty-two rabbits were infected intraarticularly by Staphylococcus aureus. The rabbits were randomly divided into four groups, including a control group and three experimental groups. Drainage was the only procedure performed in group I (control group). The animals were treated with daily intramuscular cefazolin sodium (75 mg/kg) for 7 days in group II. In group III, intraarticular ethanolic extract of propolis (0.5 mg/ml) was injected to the infected knees under sterile conditions on days 7, 14, and 21 after drainage. In group IV, the rabbits received both intramuscular cefazolin sodium as in group II and intraarticular ethanolic extract of propolis as in group III. After 8 weeks, the animals were killed and joint histopathological and scanning electron microscopic parameters were assessed. The best clinical score was obtained in group IV. There were statistically significant differences among all the groups (P<0.05). The highest total score of the histological examination was found in group I and the best total score was obtained in group IV. There were statistically significant differences among the groups when we evaluated the scores of the parameters as loss of chondrocytes, loss of matrix, and pannus in-growth (P<0.05). But there was no significant difference among the groups for the scores of cloning of the chondrocytes (P>0.05). The highest scanning electron microscopy score was found in group I and the best score was obtained in group IV. Our results confirm the safety and efficacy of intraarticular propolis and synergistic effect of propolis when used with cefazolin in an experimental septic arthritis model.

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Okkes Bilal

Imam Muhammad ibn Saud Islamic University

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