Mithun Ashok

Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety

A series of substituted triazolothiadiazoles have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1,2,4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the presence of POCl3. The triazole (5) was obtained by the fusion of 4-methylthiophenyl acetic acid with thiocarbohydrazide. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR and mass spectroscopic studies and were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.

Convenient Synthesis of Some Thiadiazolotriazinones Carrying 4-Methylthiobenzyl Moieties as Possible Antimicrobial Agents

4-amino-6-(4-methylthiobenzyl)-3-mercapto-1,2,4-triazin-5(4H)-one was condensed with various substituted benzoic acids/aryloxyacetic acids in the presence of phosphorus oxychloride to afford a series of 7-(substituted aryl/aryloxymethyl)-3-(4-methylthiobenzyl)-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones in good yields. The structures of the newly synthesized compounds were confirmed on the basis of elemental analysis, IR, 1H NMR, and mass spectral studies. All the newly synthesized compounds were tested for their antibacterial and antifungal activity against a variety of microorganisms.

Convenient synthesis of some 4'-methtylthio-containing aryl and arylfuryl pyrazolines and their antimicrobial activity studies

The condensation of 4-acetylthioanisole with different aryl and aryfuryl aldehydes under aldol conditions affords α, β-unsaturated ketones (propenones), which undergo a facile and clean cyclization with hydrazines to give pyrazolines (4–6) in quantitative yields. The structures of newly synthesized compounds have been confirmed on the basis of spectral studies. All newly synthesized compounds were tested for their antibacterial and antifungal activity.

Synthesis and Antimicrobial Evaluation of Some New Thiadiazinotriazinones Carrying 4-Methylthiobenzyl Moiety

A series of 8 H-7-(substituted aryl)-3-(4-methylthiobenzyl)-1,3,4-thiadiazino[2,3- c]-1,2,4-triazin-4-ones ( 4 ) were synthesized in good yield by condensing 4-amino-6-(4-methylthiobenzyl)-3-mercapto-1,2,4-triazin-5(4 H)-one 1 with various substituted phenacyl bromides (2) in presence of anhydrous sodium acetate, followed by the cyclization of the intermediate triazinone derivatives (3) in presence of concentrated sulphuric acid. The structures of the newly synthesized compounds were formulated on the basis of elemental analysis, IR, 1H NMR and mass spectral studies. The newly synthesized compounds were tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

Synthesis, Characterization and Antibacterial Studies of Some 1,2,4-Triazole Derivatives Containing a 6-Chloropyridin-3-yl methyl Moiety

Abstract 5-(6-Chloropyridin-3-yl methyl)-4-phenyl-1,2,4-triazole-3-thiol (2) and 5-substituted-4-phenyl- 1,2,4-triazole-3-thiols (3) were synthesized. Alkylation and aminomethylation reactions of these triazoles were also carried out. Some of the newly synthesized compounds were screened for their antibacterial activities.