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Mitsuaki Mitani

University of Tokyo

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Featured researches published by Mitsuaki Mitani.

Agricultural and biological chemistry | 1976

Chemical Modification and Structure-Activity Correlation of Salinomycin

Yukio Miyazaki; Haruyasu Kinashi; Noboru Ōtake; Mitsuaki Mitani; Tadashi Yamanishi

A number of the chemically modified compounds of salinomycin have been prepared and the structure-activity correlation between complexation affinity for cations, ion transport ability and antimicrobial activity have been investigated.The results indicate that the terminal carboxylic acid, β-hydroxyketone and allylic alcohol functions in the molecule played an important role in the exhibition of biological activity of the antibiotic.On the basis of these data, it was concluded that there is a closer parallelism between the antimicrobial and ion-transport activities of salinomycin and its derivatives.

The Journal of Antibiotics | 1968

ANTAGONISTS OF ANTIFUNGAL SUBSTANCE POLYOXIN

Mitsuaki Mitani; Yukio Inoue

The Journal of Antibiotics | 1977

STUDIES ON THE IONOPHOROUS ANTIBIOTICS. XII

Mitsuaki Mitani; Mitsuo Koenuma; Noboru Otake

The Journal of Antibiotics | 1977

Studies on the ionophorous antibiotics. VIII. Effects of monovalent and divalent cation ionophores on blood platelets.

Mitsuaki Mitani; Umetsu T; Tadashi Yamanishi

The Journal of Antibiotics | 1978

Studies on the ionophorous antibiotics. XV The monovalent cation selective ionophorous activities of carriomycin, lonomycin and etheromycin.

Mitsuaki Mitani; Noboru Otake

The Journal of Antibiotics | 1978

Studies on the ionophorous antibiotics. XVI. The ionophore-mediated calcium transport and concomitant osmotic swelling of mitochondria.

Mitsuaki Mitani; Noboru Otake

The Journal of Antibiotics | 1977

Studies on ionophorous antibiotics VII. A broad cation selective ionophore, lysocellin.

Mitsuaki Mitani; Tadashi Yamanishi; Eiichi Ebata; Noboru Otake; Mitsuo Koenuma

Agricultural and biological chemistry | 1976

Studies on the ionophorous antibiotics. VI. Chemical modification and structure-activity correlation of salinomycin.

Yukio Miyazaki; Haruyasu Kinashi; Noboru Otake; Mitsuaki Mitani; Tadashi Yamanishi

Agricultural and biological chemistry | 1978

Ionophorous properties of SY-1 (20-deoxysalinomycin) in rat liver mitochondria.

Yukio Miyazaki; Mitsuaki Mitani; Noboru Otake

The Journal of Antibiotics | 1977

Studies on the ionophorous antibiotics. XII. Effects of ionophore lysocellin on cation distribution and respiration in mitochondria.:EFFECTS OF IONOPHORE LYSOCELLIN ON CATION DISTRIBUTION AND RESPIRATION IN MITOCHONDRIA

Mitsuaki Mitani; Mitsuo Koenuma; Noboru Otake

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Noboru Otake

Teikyo University

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Mitsuo Koenuma

University of Tokyo

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Yukio Miyazaki

University of Tokyo

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Haruyasu Kinashi

Hiroshima University

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Noboru Ōtake

University of Tokyo

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