Mitsunori Yoshida
National Institutes of Health
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Publication
Featured researches published by Mitsunori Yoshida.
Genome Announcements | 2016
Mitsunori Yoshida; Kazue Nakanaga; Yoshitoshi Ogura; Atsushi Toyoda; Tadasuke Ooka; Yuko Kazumi; Satoshi Mitarai; Norihisa Ishii; Tetsuya Hayashi; Yoshihiko Hoshino
ABSTRACT Mycobacterium ulcerans subsp. shinshuense produces mycolactone and causes Buruli ulcer. Here, we report the complete sequence of its genome, which comprises a 5.9-Mb chromosome and a 166-kb plasmid (pShT-P). The sequence will represent the essential data for future phylogenetic and comparative genome studies of mycolactone-producing mycobacteria.
Genome Announcements | 2017
Mitsunori Yoshida; Yuji Miyamoto; Yoshitoshi Ogura; Tetsuya Hayashi; Yoshihiko Hoshino
ABSTRACT Mycobacterium pseudoshottsii is a fish pathogen that produces mycolactone. Here, we report the complete chromosome sequence of a type strain of M. pseudoshottsii (JCM 15466). The sequence will represent essential data for future phylogenetic and comparative genome studies of mycolactone-producing mycobacteria.
Genome Announcements | 2018
Mitsunori Yoshida; Hanako Fukano; Yuji Miyamoto; Masato Suzuki; Yoshihiko Hoshino
ABSTRACT Mycobacterium abscessus subsp. bolletii is a rapidly growing mycobacterial organism for which the taxonomy is unclear. Here, we report the complete genome sequence of a Mycobacterium abscessus subsp. bolletii type strain. This sequence will provide essential information for future taxonomic and comparative genome studies of these mycobacteria.
Scientific Reports | 2018
Kazue Nakanaga; Yoshitoshi Ogura; Atsushi Toyoda; Mitsunori Yoshida; Hanako Fukano; Nagatoshi Fujiwara; Yuji Miyamoto; Noboru Nakata; Yuko Kazumi; Shinji Maeda; Tadasuke Ooka; Masamichi Goto; Kazunari Tanigawa; Satoshi Mitarai; Koichi Suzuki; Norihisa Ishii; Manabu Ato; Tetsuya Hayashi; Yoshihiko Hoshino
Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), a WHO-defined neglected tropical disease. All Japanese BU causative isolates have shown distinct differences from the prototype and are categorized as M. ulcerans subspecies shinshuense. During repeated sub-culture, we found that some M. shinshuense colonies were non-pigmented whereas others were pigmented. Whole genome sequence analysis revealed that non-pigmented colonies did not harbor a giant plasmid, which encodes elements needed for mycolactone toxin biosynthesis. Moreover, mycolactone was not detected in sterile filtrates of non-pigmented colonies. Mice inoculated with suspensions of pigmented colonies died within 5 weeks whereas those infected with suspensions of non-pigmented colonies had significantly prolonged survival (>8 weeks). This study suggests that mycolactone is a critical M. shinshuense virulence factor and that the lack of a mycolactone-producing giant plasmid makes the strain non-pathogenic. We made an avirulent mycolactone-deletion mutant strain directly from the virulent original.
Genome Announcements | 2018
Mitsunori Yoshida; Hanako Fukano; Yoshitoshi Ogura; Yuko Kazumi; Satoshi Mitarai; Tetsuya Hayashi; Yoshihiko Hoshino
ABSTRACT Mycobacterium shigaense is a slowly growing scotochromogenic species and a member of the Mycobacterium simiae complex group. Here, we report the complete sequence of its genome, comprising a 5.2-Mb chromosome. The sequence will represent the essential data for future phylogenetic and comparative genome studies of the Mycobacterium simiae complex group.
Genome Announcements | 2017
Hanako Fukano; Mitsunori Yoshida; Yukie Katayama; Tsutomu Omatsu; Tetsuya Mizutani; Osamu Kurata; Shinpei Wada; Yoshihiko Hoshino
Genome Announcements | 2017
Mitsunori Yoshida; Shinji Izumiyama; Hanako Fukano; Kanji Sugiyama; Masato Suzuki; Yoshihiko Hoshino
International Journal of Systematic and Evolutionary Microbiology | 2018
Hanako Fukano; Mitsunori Yoshida; Yuko Kazumi; Nagatoshi Fujiwara; Kinya Katayama; Yoshitoshi Ogura; Tetsuya Hayashi; Yuji Miyamoto; Noriki Fujimoto; Wang Hongsheng; Chisaki Mizumoto; Yusuke Koizumi; Hiroyoshi Maeda; Osamu Hiranuma; Satoshi Mitarai; Norihisa Ishii; Yoshihiko Hoshino
BMC Infectious Diseases | 2018
Satoshi Okamori; Eiko Tamizu; Mitsunori Yoshida; Hanako Fukano; Yuichiro Hayashi; Masaki Fujita; Yoshihiko Hoshino; Tomoko Betsuyaku; Naoki Hasegawa
Genome Announcements | 2018
Mitsunori Yoshida; Hanako Fukano; Yuji Miyamoto; Masato Suzuki; Yoshihiko Hoshino