Mizuho Kimura

Contact sensitivity induced by neomycin with cross-sensitivity to other aminoglycoside antibiotics

1. Kaniwa M, Isama K, Nakamura A et al. Identification of causitive chemicals of allergic contact dermatitis using a combination of patch testing patients and chemical analysis. Contact Dermatitis 1994: 30: 26–34. 2. Lear J T, English J S C. Hand involvement in allergic contact dermatitis from mercaptobenzothiazole in shoes. Contact Dermatitis 1996: 34: 432. 3. Bruze M, Almgren G. Occupational dermatoses in workers exposed to resins based on phenol and formaldehyde. Contact Dermatitis 1988: 19: 272–277.

Photosensitivity induced by lomefloxacin with cross-photosensitivity to ciprofloxacin and fleroxacin

A 69-year-old man was seen in June 1997 with erythema, vesicles, and edema on his face and red papules on his dorsal hands that had started a few days before. He had been taking lomefloxacin (LFLX) (BareonA, Hokuriku Co. Ltd, Fukui, Japan) 200 mg t.d.s. and lysozyme chloride 90 mg t.d.s. orally for rhinitis for 2 weeks. The patient had never taken ciprofloxacin (CPFX) or fleroxacin (FLRX). We performed phototesting as previously described (1) with a Dermaray, Model M-DMR-1 (Eisai Co. Ltd., Tokyo) as light source (2, 3), 4 weeks after the patient stopped taking LFLX and lysozyme chloride. UVBMED (minimal erythema dose) was normal (60 mJ/ cm2), and irradiation with 13.5 J/cm2 for UVA produced no response, suggesting that the photosensitivity of the patient had become normal. Patch and photopatch tests were carried out with 10, 1, and 0.1% pet. LFLX, and 10% pet. CPFX, sparfloxacin (SPFX), and FLRX. LFLX (10% and 1%), CPFX (10%), and FLRX (10%) in pet. with UVA-irradiation (4.5 J/cm2) produced erythema and small papules with pruritus 1 day after irradiation. Patch and photopatch tests with LFLX, CPFX, SPFX, and FLRX in 5 normal subjects showed no erythema or papular response 2 days after application or 1 day after irradiation. Oral photochallenge test with lysozyme chloride 30 mg and 4.5 J/cm2 UVA gave no response.

Photosensitivity induced by fleroxacin

A case of photosensitivity induced by fleroxadn (FLRX) is reported. A 71‐year‐old man had erythema on sun‐exposed areas after 5 months FLRX treatment for prostatitis. The minimal erythema dose to UVA was reduced at the initial examination and became normal 4 weeks after he stopped taking FLRX. Oral photo‐challenge with FLRX 100 mg was positive, but photopatch testing was negative.

Contact dermatitis due to trisodium ethylenediaminetetra-acetic acid (EDTA) in a cosmetic lotion.

4. Nielsen J, Welinder H, Skerfving S. Allergic airway disease caused by methyltetrahydrophthalic anhydride in epoxy resin. Scand J Work Environ Health 1989: 15: 154–155. 5. Welinder H, Nielsen J, Gustavsson C, Bensryd I, Skerfving S. Specific antibodies to methyltetrahydrophthalic anhydride in exposed workers. Clin Exp Allergy 1990: 20: 639– 645. 6. Yokota K, Yamaguchi K, Takeshita T, Morimoto K. The significance of specific IgG4 antibodies to methyltetrahydrophthalic anhydride in occupationally exposed subjects. Clin Exp Allergy 1998: 28: 694–701. 7. Jolanki R, Estlander T, Kanerva L. Occupational contact dermatitis and contact urticaria caused by epoxy resins. Acta Dermato-venereologica 1987: (suppl) 134: 90–94. 8. Jolanki R, Kanerva L, Estlander T, Tarvainen K, Keskinen H, Henricks-Eckerman M-L. Occupational dermatoses from epoxy resin compounds. Contact Dermatitis 1990: 23: 172–183. 9. Kanerva L, Tupasela O, Jolanki R, Tarvainen K, Estlander T. Histopathology and electron microscopy of long-lasting IgE-mediated skin prick test reaction caused by methyltetrahydrophthalic anhydride and methylhexahydrophthalic anhydride. In: Czernielewski J M (ed): Immunological and pharmacological aspects of atopic and contact eczema. Pharmacol Skin. Basel: Karger, 1991: 4: 106–108.

A case of urticarial drug eruption from loxoprofen sodium

isH.WAKKLlN F,WOJ\ARUtt,SKA clearance of UP after treatment at six years, and therefore suggest tfiat localized, cosnieticalh important sites could be treated by this method. In addition, we recommend that hydrocolloid occlusion is used, as it may confer additional benefits to the steroid therapy in maintaining remission. Treatment of more extensive UP by this method, however, may be impractical and carry the risk of systemic side-effects, while care also needs to be taken to monitor for signs of steroid skin atrophy.

Drug eruption due to bucillamine

A 56-year-old woman had had rheumatoid arthritis (RA) for over 30 years, and received drug therapy (loxoprofen and sofalcone) in our hospital for 7 months. She was seen in June 1997 with red papules on the face, neck and arms that had started a few days before. She had been taking bucillamine (RimatilA, Santen, Osaka, Japan) 100 mg q.d.s. orally for 2 weeks, in addition to loxoprofen 60 mg t.d.s. and sofalcone 50 mg t.d.s. We performed patch tests with 20, 10, 1, and 0.1% pet. bucillamine. 20 and 10% pet. bucillamine produced erythema and papules with pruritus at D2 and D3, and 1% pet. bucillamine produced red papules with pruritus at D3, but 0.1% pet. showed no response. Moreover, patch tests carried out with 20, 10, 1, and 0.1% pet. penicillamine produced no erythema or papular response at D2 and D3. Patch tests with 30 and 10% pet. bucillamine in 8 normal subjects showed erythema and papules at D2 and D3 in 3 subjects, and patch tests with 1 and 0.1% pet. bucillamine in these 8 subjects showed no erythema or papular response at D2 and D3. LST (lymphocyte stimulation test) with bucillamine was negative.

Drug eruption due to flavoxate hydrochloride

on her eyelids (Fig. 1). She did not use eyelash curlers or any other cosmetics, but had applied an eyelid paste on her upper eyelids every morning for 2 years for cosmetic purposes. The dermatitis disappeared soon after discontinuing the eyelid paste application followed by treatment with topical corticosteroid. Patch testing with an occlusion time of 2 days on her back gave positive reactions on days 3, 4, and 7 to the eyelid paste (as is) and its chief ingredient (50% v/v) natural rubber latex (NRL) (low ammonia, 10% pet.). No reactions were detected to parabens, fragrances or other ingredients, including rubber additives and pre-