Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Mohammed N. Khan is active.

Publication


Featured researches published by Mohammed N. Khan.


The New England Journal of Medicine | 2008

Pulmonary-Vein Isolation for Atrial Fibrillation in Patients with Heart Failure

Mohammed N. Khan; Pierre Jaïs; Jennifer E. Cummings; Luigi Di Biase; Prashanthan Sanders; David O. Martin; Josef Kautzner; Steven Hao; Sakis Themistoclakis; Raffaele Fanelli; Domenico Potenza; Raimondo Massaro; Oussama Wazni; Robert A. Schweikert; Walid Saliba; Paul J. Wang; Amin Al-Ahmad; Salwa Beheiry; Pietro Santarelli; Randall C. Starling; Antonio Dello Russo; Gemma Pelargonio; Johannes Brachmann; Volker Schibgilla; Aldo Bonso; Michela Casella; Antonio Raviele; Michel Haïssaguerre; Andrea Natale

BACKGROUND Pulmonary-vein isolation is increasingly being used to treat atrial fibrillation in patients with heart failure. METHODS In this prospective, multicenter clinical trial, we randomly assigned patients with symptomatic, drug-resistant atrial fibrillation, an ejection fraction of 40% or less, and New York Heart Association class II or III heart failure to undergo either pulmonary-vein isolation or atrioventricular-node ablation with biventricular pacing. All patients completed the Minnesota Living with Heart Failure questionnaire (scores range from 0 to 105, with a higher score indicating a worse quality of life) and underwent echocardiography and a 6-minute walk test (the composite primary end point). Over a 6-month period, patients were monitored for both symptomatic and asymptomatic episodes of atrial fibrillation. RESULTS In all, 41 patients underwent pulmonary-vein isolation, and 40 underwent atrioventricular-node ablation with biventricular pacing; none were lost to follow-up at 6 months. The composite primary end point favored the group that underwent pulmonary-vein isolation, with an improved questionnaire score at 6 months (60, vs. 82 in the group that underwent atrioventricular-node ablation with biventricular pacing; P<0.001), a longer 6-minute-walk distance (340 m vs. 297 m, P<0.001), and a higher ejection fraction (35% vs. 28%, P<0.001). In the group that underwent pulmonary-vein isolation, 88% of patients receiving antiarrhythmic drugs and 71% of those not receiving such drugs were free of atrial fibrillation at 6 months. In the group that underwent pulmonary-vein isolation, pulmonary-vein stenosis developed in two patients, pericardial effusion in one, and pulmonary edema in another; in the group that underwent atrioventricular-node ablation with biventricular pacing, lead dislodgment was found in one patient and pneumothorax in another. CONCLUSIONS Pulmonary-vein isolation was superior to atrioventricular-node ablation with biventricular pacing in patients with heart failure who had drug-refractory atrial fibrillation. (ClinicalTrials.gov number, NCT00599976.)


Pacing and Clinical Electrophysiology | 2005

Delayed Lead Perforation: A Disturbing Trend

Mohammed N. Khan; George Joseph; Yaariv Khaykin; Khaled M. Ziada; Bruce L. Wilkoff

Background: Delayed lead perforation (occurring more than 1 month after implantation) is a rare complication. Its pathophysiology and optimal management are currently unclear.


Journal of Cardiovascular Electrophysiology | 2008

Low Incidence of Left Atrial or Left Atrial Appendage Thrombus in Patients with Paroxysmal Atrial Fibrillation and Normal EF Who Present for Pulmonary Vein Antrum Isolation Procedure

Mohammed N. Khan; Ali Usmani; Saira Noor; Samy Elayi; Chi Keong Ching; Luigi Di Biase; Dimpi Patel; J. David Burkhardt; Jennifer E. Cummings; Robert A. Schweikert; Walid Saliba; Andrea Natale

Introduction: The incidence of left atrial appendage (LAA) thrombus in patients with paroxysmal atrial fibrillation (PAF) who present for pulmonary vein antrum isolation procedure (PVAI) is unknown.


American Journal of Cardiology | 2005

Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol).

Mohammed N. Khan; Claire E. Pothier; Michael S. Lauer


Heart Rhythm | 2006

AB18-1: Progression of atrial fibrillation in the pulmonary vein antrum isolation vs. AV node ablation with bi-ventricular pacing for treatment of atrial fibrillation in patients with congestive heart failure trial (PABA CHF)

Mohammed N. Khan; Pierre Jaı̈s; Jennifer E. Cummings; Prashanthan Sanders; Josef Kautzner; Steven Hao; Sakis Themistoclakis; Raffaele Fanelli; Domenico Potenza; Oussama Wazni; Paul J. Wang; Amin Al-Ahmad; Salwa Beheiry; Ennio Pisano; Pietro Santarelli; Randall C. Starling; Robert A. Schweikert; Antonio Russo; Gemma Pelargonio; Johannes Brachmann; Jens Gunther; Aldo Bonso; Antonio Raviele; Michel Haı̈ssaguerre; Andrea Natale


American Journal of Cardiology | 2007

Quadricuspid Aortic Valve Diagnosed by Echocardiography in Two Cases Identical Twins

Patrick Fratellone; Marvin Berger; Mohammed N. Khan; Michael Bassiri-Tehrani


Heart Rhythm | 2006

P4-104: Hospitalization due to atrial fibrillation in patients with cardiac resynchronization therapy

Mohammed N. Khan; Marketa Kozeluhova; Dimpi Patel; Prasad Subramanya; Dhanunjaya Lakkireddy; Kenneth C. Civello; Mohamed Kanj; Claude S. Elayi; Sergio Thal; Robert A. Schweikert; Amin Al-Ahmad; Paul J. Wang; Andrea Natale


Heart Rhythm | 2006

P3-74: Success of radiofrequency catheter ablation of atrial fibrillation: Does obesity influence the outcomes?

Dhanunjaya R. Lakkireddy; Dimpi Patel; Martin Rotter; Michel Haïssaguerre; Atul Verma; Sergio Thal; Oussama Wazni; Mohamed Kanj; Mohammed N. Khan; Fethi Kilicaslan; Mauricio Arruda; Mandeep Bhargava; Walid Saliba; David O. Martin; Robert A. Schweikert; Jennifer E. Cummings; Patrick Tchou; Andrea Natale


Archive | 2009

Catheter Ablation of Atrial Fibrillation in Patients with Heart Failure

Ibrahim S. Abu Romeh; Mohammed N. Khan; Andrea Natale


Journal of Cardiovascular Electrophysiology | 2007

Response to the editor: [5]

Soufian Almahameed; Mohammed N. Khan; Andrea Natale

Collaboration


Dive into the Mohammed N. Khan's collaboration.

Top Co-Authors

Avatar

Andrea Natale

University of Texas at Austin

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge