Mohammed N. Khan
Cleveland Clinic
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Publication
Featured researches published by Mohammed N. Khan.
The New England Journal of Medicine | 2008
Mohammed N. Khan; Pierre Jaïs; Jennifer E. Cummings; Luigi Di Biase; Prashanthan Sanders; David O. Martin; Josef Kautzner; Steven Hao; Sakis Themistoclakis; Raffaele Fanelli; Domenico Potenza; Raimondo Massaro; Oussama Wazni; Robert A. Schweikert; Walid Saliba; Paul J. Wang; Amin Al-Ahmad; Salwa Beheiry; Pietro Santarelli; Randall C. Starling; Antonio Dello Russo; Gemma Pelargonio; Johannes Brachmann; Volker Schibgilla; Aldo Bonso; Michela Casella; Antonio Raviele; Michel Haïssaguerre; Andrea Natale
BACKGROUND Pulmonary-vein isolation is increasingly being used to treat atrial fibrillation in patients with heart failure. METHODS In this prospective, multicenter clinical trial, we randomly assigned patients with symptomatic, drug-resistant atrial fibrillation, an ejection fraction of 40% or less, and New York Heart Association class II or III heart failure to undergo either pulmonary-vein isolation or atrioventricular-node ablation with biventricular pacing. All patients completed the Minnesota Living with Heart Failure questionnaire (scores range from 0 to 105, with a higher score indicating a worse quality of life) and underwent echocardiography and a 6-minute walk test (the composite primary end point). Over a 6-month period, patients were monitored for both symptomatic and asymptomatic episodes of atrial fibrillation. RESULTS In all, 41 patients underwent pulmonary-vein isolation, and 40 underwent atrioventricular-node ablation with biventricular pacing; none were lost to follow-up at 6 months. The composite primary end point favored the group that underwent pulmonary-vein isolation, with an improved questionnaire score at 6 months (60, vs. 82 in the group that underwent atrioventricular-node ablation with biventricular pacing; P<0.001), a longer 6-minute-walk distance (340 m vs. 297 m, P<0.001), and a higher ejection fraction (35% vs. 28%, P<0.001). In the group that underwent pulmonary-vein isolation, 88% of patients receiving antiarrhythmic drugs and 71% of those not receiving such drugs were free of atrial fibrillation at 6 months. In the group that underwent pulmonary-vein isolation, pulmonary-vein stenosis developed in two patients, pericardial effusion in one, and pulmonary edema in another; in the group that underwent atrioventricular-node ablation with biventricular pacing, lead dislodgment was found in one patient and pneumothorax in another. CONCLUSIONS Pulmonary-vein isolation was superior to atrioventricular-node ablation with biventricular pacing in patients with heart failure who had drug-refractory atrial fibrillation. (ClinicalTrials.gov number, NCT00599976.)
Pacing and Clinical Electrophysiology | 2005
Mohammed N. Khan; George Joseph; Yaariv Khaykin; Khaled M. Ziada; Bruce L. Wilkoff
Background: Delayed lead perforation (occurring more than 1 month after implantation) is a rare complication. Its pathophysiology and optimal management are currently unclear.
Journal of Cardiovascular Electrophysiology | 2008
Mohammed N. Khan; Ali Usmani; Saira Noor; Samy Elayi; Chi Keong Ching; Luigi Di Biase; Dimpi Patel; J. David Burkhardt; Jennifer E. Cummings; Robert A. Schweikert; Walid Saliba; Andrea Natale
Introduction: The incidence of left atrial appendage (LAA) thrombus in patients with paroxysmal atrial fibrillation (PAF) who present for pulmonary vein antrum isolation procedure (PVAI) is unknown.
American Journal of Cardiology | 2005
Mohammed N. Khan; Claire E. Pothier; Michael S. Lauer
Heart Rhythm | 2006
Mohammed N. Khan; Pierre Jaı̈s; Jennifer E. Cummings; Prashanthan Sanders; Josef Kautzner; Steven Hao; Sakis Themistoclakis; Raffaele Fanelli; Domenico Potenza; Oussama Wazni; Paul J. Wang; Amin Al-Ahmad; Salwa Beheiry; Ennio Pisano; Pietro Santarelli; Randall C. Starling; Robert A. Schweikert; Antonio Russo; Gemma Pelargonio; Johannes Brachmann; Jens Gunther; Aldo Bonso; Antonio Raviele; Michel Haı̈ssaguerre; Andrea Natale
American Journal of Cardiology | 2007
Patrick Fratellone; Marvin Berger; Mohammed N. Khan; Michael Bassiri-Tehrani
Heart Rhythm | 2006
Mohammed N. Khan; Marketa Kozeluhova; Dimpi Patel; Prasad Subramanya; Dhanunjaya Lakkireddy; Kenneth C. Civello; Mohamed Kanj; Claude S. Elayi; Sergio Thal; Robert A. Schweikert; Amin Al-Ahmad; Paul J. Wang; Andrea Natale
Heart Rhythm | 2006
Dhanunjaya R. Lakkireddy; Dimpi Patel; Martin Rotter; Michel Haïssaguerre; Atul Verma; Sergio Thal; Oussama Wazni; Mohamed Kanj; Mohammed N. Khan; Fethi Kilicaslan; Mauricio Arruda; Mandeep Bhargava; Walid Saliba; David O. Martin; Robert A. Schweikert; Jennifer E. Cummings; Patrick Tchou; Andrea Natale
Archive | 2009
Ibrahim S. Abu Romeh; Mohammed N. Khan; Andrea Natale
Journal of Cardiovascular Electrophysiology | 2007
Soufian Almahameed; Mohammed N. Khan; Andrea Natale