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Monte D. Gruett

Rensselaer Polytechnic Institute

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Publication

Featured researches published by Monte D. Gruett.

Bioorganic & Medicinal Chemistry Letters | 1995

The antitumor activity of novel pyrazoloquinoline derivatives

Mark P. Wentland; Suzanne C. Aldous; Monte D. Gruett; Robert B. Perni; Ronald G. Powles; Deborah W. Danz; Kristina M. Klingbeil; A.Danielle Peverly; Ronald G. Robinson; Thomas H. Corbett; James B. Rake; Susan A. Coughlin

Abstract Mammalian topoisomerase II inhibition activity has been identified in a series of novel pyrazoloquinoline derivatives; potency for two analogues containing cyclohexyl groups at the 2-position was comparable to the reference agents, mAMSA and VP-16. In several instances, topo II inhibition translated to a high level of in vitro cytotoxicity and murine antitumor activity.

Journal of Medicinal Chemistry | 1962

1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS.

George Y. Lesher; Ernest J. Froelich; Monte D. Gruett; John Hays. Bailey; R. Pauline Brundage

Journal of Medicinal Chemistry | 1993

Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives

Mark P. Wentland; George Y. Lesher; Michael Reuman; Monte D. Gruett; Baldev Singh; Suzanne C. Aldous; Peter Hans Dorff; James B. Rake; Susan A. Coughlin

Archive | 1961

4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters

Monte D. Gruett; George Y. Lesher

Journal of Medicinal Chemistry | 1995

Synthesis and antibacterial activity of some novel 1-substituted 1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. Potent antistaphylococcal agents.

Michael Reuman; Sol J. Daum; Baldev Singh; Mark P. Wentland; Robert B. Perni; Patrick O. Pennock; Philip M. Carabateas; Monte D. Gruett; Manohar Saindane; Peter Hans Dorff; Susan A. Coughlin; David M. Sedlock; James B. Rake; George Y. Lesher

Archive | 1968

NAPHTHYRIDINE-3-CARBOXYLIC ACIDS,THEIR DERIVATIVES AND PREPARATION THEREOF

George Y. Lesher; Monte D. Gruett

Journal of Heterocyclic Chemistry | 1984

1-Ethyl-1,4-dihydro-4-oxo-7-(pyridinyl)-3-quinolinecarboxylic acids. I. Synthesis of 3- and 4-(3-aminophenyl)pyridine intermediates

Philip M. Carabateas; R. Pauline Brundage; Karl O. Gelotte; Monte D. Gruett; Roman R. Lorenz; Chester J. Opalka; Baldev Singh; William H. Thielking; Gordon L. Williams; George Y. Lesher

Archive | 1981

1H-Indole-2,3-dione derivatives

George Y. Lesher; Donald F. Page; Monte D. Gruett

Journal of Heterocyclic Chemistry | 1984

1-Ethyl-1,4-dihydro-4-oxo-7-(pyridinyl)-3-quinolinecarboxylic acids. II. Synthesis

Philip M. Carabateas; R. Pauline Brundage; Karl O. Gelotte; Monte D. Gruett; Roman R. Lorenz; Chester J. Opalka; Baldev Singh; William H. Thielking; Gordon L. Williams; George Y. Lesher

Archive | 1980

5-(Pyridinyl)-1H-pyrazolo[3,4-b]pyridine-3-amines, their use as cardiotonics and their preparation

George Y. Lesher; Monte D. Gruett

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George Y. Lesher

Rensselaer Polytechnic Institute

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James B. Rake

Eastman Kodak Company

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Mark P. Wentland

Rensselaer Polytechnic Institute

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Philip M. Carabateas

Rensselaer Polytechnic Institute

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R. Pauline Brundage

Rensselaer Polytechnic Institute

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Susan A. Coughlin

Eastman Kodak Company

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Baldev Singh

Council of Scientific and Industrial Research

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Chester J. Opalka

Rensselaer Polytechnic Institute

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Donald F. Page

Rensselaer Polytechnic Institute

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Gordon L. Williams

Rensselaer Polytechnic Institute

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