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Motohiko Taki

Hokkaido University

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Publication

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FEBS Letters | 1991

Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels

Motohiko Taki; Hitoshi Nakayama; Yuichi Kanaoka

A new 1,4‐dihydropyridine photoaffinity ligand, [3H]diazipine, has been assessed by binding and photolabeling, and compared with a currently used [3H]Diazipine reversibly binds to skeletal muscle Ca2+ channels with a similar affinity of [3H]azidopine, but [3H]diazipine labels the channels two times more efficiently and no release of the incorporated amount is observed after dithiothreitol treatment.

Archive | 1993

Synthesis and Properties of Diazipine, a Novel Photoaffinity Probe for Calcium Channel-Linked Dihydropyridine Receptors

Hitoshi Nakayama; Motohiko Taki; Yuichi Kanaoka

Photoaffinity labeling techniques using reagents with ligand structures have versatile roles in picking up and identifying receptor molecules of the ligands in crude preparations, and even in locating or identifying the binding sites of the ligands in the receptor molecules.

Proceedings of the National Academy of Sciences of the United States of America | 1991

Identification of 1,4-dihydropyridine binding regions within the alpha 1 subunit of skeletal muscle Ca2+ channels by photoaffinity labeling with diazipine.

Hitoshi Nakayama; Motohiko Taki; Jörg Striessnig; Hartmut Glossmann; William A. Catterall; Yuichi Kanaoka

Planta Medica | 1998

Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship.

Kitaoka M; Kadokawa H; Sugano M; Ichikawa K; Motohiko Taki; Sachiko Takaishi; Yasuteru Iijima; Tsutsumi S; Boriboon M; Toshiyuki Akiyama

Planta Medica | 1997

Retrodihydrochalcones and Homoisoflavones Isolated from Thai Medicinal Plant Dracaena loureiri and their Estrogen Agonist Activity

Ichikawa K; Kitaoka M; Motohiko Taki; Sachiko Takaishi; Yasuteru Iijima; Boriboon M; Toshiyuki Akiyama

Chemical & Pharmaceutical Bulletin | 2000

Structures of 4-aryl-coumarin (neoflavone) dimers isolated from Pistacia chinensis Bunge and their estrogen-like activity.

Satoshi Nishimura; Motohiko Taki; Sachiko Takaishi; Yasuteru Iijima; Toshiyuki Akiyama

Chemical & Pharmaceutical Bulletin | 2000

Stereochemistry of cis- and trans-Hinokiresinol and Their Estrogen-like Activity

Emiko Minami; Motohiko Taki; Sachiko Takaishi; Yasuteru Iijima; Shinya Tsutsumi; Toshiyuki Akiyama

Archive | 1996

Flavone and naphthalene derivative

Katsumi Fujimoto; Yasuteru Iijima; Yuji Iwano; Masahiro Kitaoka; Isamu Mikoshiba; Motohiko Taki; Natsuki Tanaka; 政弘 北岡; 雄次 岩野; 勇 御子芝; 基彦 瀧; 夏樹 田中; 克巳 藤本; 康輝 飯島

Annals of the New York Academy of Sciences | 1993

Identification of Ligand-Binding Sites that Form External Mouth of Ion Pore in Calcium and Sodium Channels

Hitoshi Nakayama; Yasumaru Hatanaka; Motohiko Taki; Eiichi Yoshida; Yuichi Kanaoka

Chemical & Pharmaceutical Bulletin | 1991

Synthesis of Diazipine and (3H) Diazipine: Novel Dihydropyridines as Photoaffinity Probes of Calcium Channels.

Motohiko Taki; Akihiko Kuniyasu; Hitoshi Nakayama; Yuichi Kanaoka

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Collaboration

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Hitoshi Nakayama

Hokkaido University

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Yasuteru Iijima

University of Tokyo

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Toshiyuki Akiyama

Tokyo Institute of Technology

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Yuichi Kanaoka

Hokkaido University

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Yasumaru Hatanaka

University of Toyama

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Akihiko Kuniyasu

Kumamoto University

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Eiichi Yoshida

Hokkaido University

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Hartmut Glossmann

Hokkaido University

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Jörg Striessnig

Hokkaido University

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Mikio Yamazaki

Chiba University

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