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Motonobu Ichino

University of Tokyo

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Publication

Featured researches published by Motonobu Ichino.

GANN Japanese Journal of Cancer Research | 1975

ACTION OF 5-FLUOROCYCLOCYTIDINE ON CULTURED L-5178Y CELLS

Mitsuzi Yoshida; Akio Hoshi; Kazuo Kuretani; Tadashi Kanai; Motonobu Ichino

Effect of substitution of 5-position of cyclocytidine with fluorine on its antitumor activity in cultured cells was examined. 5-Fluorocyclocytidine was active against cultured L-5178Y cells similar to cyclocytidine. IC50 of the compound was 0.054 mug/ml. This compound inhibited thymidine incorporation into acid-soluble fraction of the cells. Cell growth inhibition by 5-fluorocyclocytidine was reversed by deoxycytidine but not by thymidine and deoxyuridine. On the other hand, cell growth inhibition by 5-fluorouracil was reversed by thymidine and deoxyuridine. As a result, site of action of 5-fluorocyclocytidine was considered to be similar to that of cyclocytidine and not to 5-fluorouracil.

Tetrahedron Letters | 1971

Direct halogenation of sugar moiety of nucleosides

Kiyomi Kikugawa; Motonobu Ichino

Journal of Medicinal Chemistry | 1973

Platelet aggregation inhibitors. 4. N 6 -substituted adenosines.

Kiyomi Kikugawa; Kazuhiro Iizuka; Motonobu Ichino

Journal of Organic Chemistry | 1972

Studies on the Vilsmeier-Haack reaction. IV. Convenient synthesis of 2,2'-anhydro-1- -D-arabinofuranosylcytosine (2,2'-cyclocytidine) and its derivatives.

Kiyomi Kikugawa; Motonobu Ichino

Journal of Medicinal Chemistry | 1973

Platelet aggregation inhibitors. 6. 2-Thioadenosine derivatives.

Kiyomi Kikugawa; Hideo Suehiro; Motonobu Ichino

Journal of Medicinal Chemistry | 1972

Platelet aggregation inhibitors. 2. Inhibition of platelet aggregation by 5'-, 2-, 6-, and 8-substituted adenosines

Kiyomi Kikugawa; Kazuhiro Iizuka; Yoshiyuki Higuchi; Hachihiko Hirayama; Motonobu Ichino

Chemical & Pharmaceutical Bulletin | 1970

Pyrimidine Nucleosides. III. Reaction of Cytidine or N4-Acetylcytidine with Partially Hydrolyzed Phosphorus Oxychloride

Tadashi Kanai; Takashi Kojima; Osamu Maruyama; Motonobu Ichino

Journal of Medicinal Chemistry | 1974

Pyrimidine nucleosides. 6. Syntheses and anticancer activities of N4-substituted 2,2'-anhydronucleosides.

Tadashi Kanai; Motonobu Ichino; Akio Hoshi; Fumihiko Kanzawa; Kazuo Kuretani

Archive | 1973

S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors

Kiyomi Kikugawa; Hideo Suehiro; Kazuhiro Iizuka; Leiko Sugata; Motonobu Ichino; Tokuro Nakamura

Chemical & Pharmaceutical Bulletin | 1973

Platelet Aggregation Inhibitors. V. Pyrimidine Derivatives, Indole Derivatives, Benzothiophenes, and Benzoquinolizine Derivative

Kiyomi Kikugawa; Motonobu Ichino

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Kiyomi Kikugawa

University of Tokyo

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Tadashi Kanai

University of Tokyo

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Kazuo Kuretani

National Cancer Research Institute

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Akio Hoshi

Ehime University

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Mitsuzi Yoshida

Hokkaido University

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Masaaki Iigo

Hokkaido University

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Takashi Kojima

Takeda Pharmaceutical Company

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Tyunoshin Ukita

University of Tokyo

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Tsuneo Kusama

University of Tokyo

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Akio Hoshi

Ehime University

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