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Tadashi Kanai

University of Tokyo

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Featured researches published by Tadashi Kanai.

GANN Japanese Journal of Cancer Research | 1975

ACTION OF 5-FLUOROCYCLOCYTIDINE ON CULTURED L-5178Y CELLS

Mitsuzi Yoshida; Akio Hoshi; Kazuo Kuretani; Tadashi Kanai; Motonobu Ichino

Effect of substitution of 5-position of cyclocytidine with fluorine on its antitumor activity in cultured cells was examined. 5-Fluorocyclocytidine was active against cultured L-5178Y cells similar to cyclocytidine. IC50 of the compound was 0.054 mug/ml. This compound inhibited thymidine incorporation into acid-soluble fraction of the cells. Cell growth inhibition by 5-fluorocyclocytidine was reversed by deoxycytidine but not by thymidine and deoxyuridine. On the other hand, cell growth inhibition by 5-fluorouracil was reversed by thymidine and deoxyuridine. As a result, site of action of 5-fluorocyclocytidine was considered to be similar to that of cyclocytidine and not to 5-fluorouracil.

Chemical & Pharmaceutical Bulletin | 1970

Pyrimidine Nucleosides. III. Reaction of Cytidine or N4-Acetylcytidine with Partially Hydrolyzed Phosphorus Oxychloride

Tadashi Kanai; Takashi Kojima; Osamu Maruyama; Motonobu Ichino

Journal of Medicinal Chemistry | 1974

Pyrimidine nucleosides. 6. Syntheses and anticancer activities of N4-substituted 2,2'-anhydronucleosides.

Tadashi Kanai; Motonobu Ichino; Akio Hoshi; Fumihiko Kanzawa; Kazuo Kuretani

Journal of Medicinal Chemistry | 1972

Pyrimidine nucleosides. 5. Syntheses of carcinostatic halogenocyclonucleosides.

Tadashi Kanai; Motonobu Ichino; Akio Hoshi; Fumihiko Kanzawa; Kazuo Kuretani

Chemical & Pharmaceutical Bulletin | 1972

Specific Inhibition of DNA Synthesis by Cyclocytidine

Akio Hoshi; Mitsuzi Yoshida; Fumihiko Kanzawa; Kazuo Kuretani; Tadashi Kanai; Motonobu Ichino

Chemical & Pharmaceutical Bulletin | 1974

Autoradiographic Study on the Distribution of Cyclocytidine in Mice

Akio Hoshi; Masaaki Iigo; Kazuo Kuretani; Tadashi Kanai; Motonobu Ichino

Tetrahedron Letters | 1971

Some phosphate esters of cyclocytidine and aracytidine

Tadashi Kanai; Motonobu Ichino; Akio Hoshi; Kazuo Kuretani

Chemical & Pharmaceutical Bulletin | 1975

Metabolism of Cyclocytidine and Aracytidine in Mice

Akio Hoshi; Mitsuzi Yoshida; Kazuo Kuretani; Tadashi Kanai; Motonobu Ichino

Chemical & Pharmaceutical Bulletin | 1973

Inhibition by Cyclocytidine of Nucleic Acid Biosynthesis in Cultured Cells (L5178Y)

Akio Hoshi; Mitsuzi Yoshida; Fumihiko Kanzawa; Kazuo Kuretani; Tadashi Kanai; Motonobu Ichino

Chemical & Pharmaceutical Bulletin | 1968

Pyrimidine Nucleosides. I. The Convenient Synthesis of 1-β-D-Lyxofuranosylcytosine from Cytidine

Tadashi Kanai; Motonobu Ichino

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Motonobu Ichino

University of Tokyo

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Akio Hoshi

Ehime University

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Kazuo Kuretani

National Cancer Research Institute

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Mitsuzi Yoshida

Hokkaido University

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Hachihiko Hirayama

University of Tokyo

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Masaaki Iigo

Hokkaido University

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Taisuke Sugihara

University of Tokyo

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Takashi Kojima

Takeda Pharmaceutical Company

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Fukusabroh Hamada

University of Tokyo

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Kazuo Kuretani

National Cancer Research Institute

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