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Dive into the research topics where Muhammad Saqlain is active.

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Featured researches published by Muhammad Saqlain.


Gene | 2018

Association of CACNA1C with bipolar disorder among the Pakistani population

Madiha Khalid; Terri M. Driessen; Jong Seo Lee; Leon Tejwani; Asad Rasool; Muhammad Saqlain; Pakeeza Arzoo Shiaq; Muhammad Hanif; Amber Nawaz; Andrew T. DeWan; Ghazala Kaukab Raja; Janghoo Lim

Many single nucleotide polymorphisms (SNPs) have been identified for Bipolar disorder (BD), but association between SNPs and BD can vary depending on the population tested. SNPs rs10994336 and rs9804190 in ANK3 and rs1006737 in CACNA1C have emerged as the most highly replicated SNPs significantly associated with BD. The aim of the present study was to assess the association of these SNPs with BD in the Pakistani population, which has never before been examined. A total of 120 BD and 120 control individuals from Pakistan were examined in this analysis. Genotyping results indicated that rs1006737 in CACNA1C was significantly associated with BD, while rs10994336 or rs9804190 in ANK3 was not significant when examined individually. However, risk score assessment found that the presence of two or more risk alleles was significantly associated with disease, indicating that risk alleles from ANK3 and CACNA1C may additively contribute to BD. A protein-protein interaction network was generated using STRING to probe the relationship between ANK3 and CACNA1C interactors and their associations with BD. While none of the interactors are directly linked to BD, they play a role in pathways linked to BD, including oxytocin and dopamine signaling pathways. Collectively, these results reveal a significant association of CACNA1C with BD among the Pakistani population, extending results from other ethnic groups to the Pakistani population for the first time.


Asthma Research and Practice | 2018

Single nucleotide polymorphisms in asthma candidate genes TBXA2R , ADAM33 FCER1B and ORMDL3 in Pakistani asthmatics a case control study

Nusrat Saba; Osman Yusuf; Sadia Rehman; Saeeda Munir; Amna Noor; Muhammad Saqlain; Atika Mansoor; Ghazala Kaukab Raja

BackgroundGenetic variations in different loci and genes are important in asthma pathogenesis. There is much importance of various immunological pathways in the IgE secretion regulation. Alterations in any main part of these pathways can increase the risk of asthma development. Polymorphisms in these genetic markers can effect certain pathways which predict the asthma susceptibility. In the present study, SNPs directly or indirectly affecting the immunological process pathways are selected.MethodsThis study was conducted to determine association of 16 SNPs in 10 candidate genes with asthma in Pakistani population in 333 asthmatic cases and 220 healthy controls. Genotyping was performed using the Sequenom Mass ARRAY iPLEX platform (14 SNPs) and TaqMan assay (2 SNPs).ResultsThe minor allele at two of the SNPs showed association with protection from asthma, rs1131882 in TBXA2R gene (OR 0.73, 95% CI 0.52–1.01, P = 0.05) and rs2280091 in the ADAM33 gene (OR 0.69, 95% CI 0.50–0.97, P = 0.03). For FCER1B gene, rs2583476 the asthmatic male gender had higher TT genotype counts as compared to controls (OR = 1.86, 95% CI = 1.09–3.17, p = 0.01). In rs11650680 of ORMDL3 gene the CT genotype is more prevalent in female asthma cases in comparison with female controls (OR = 1.99, 95% CI = 1.02–3.89, p = 0.03).ConclusionsThis data suggests that variations at TBXA2R and ADAM33 genes are found to be associated with asthma susceptibility in Pakistan. FCER1B gene is associated with male and ORMDL3 in female asthmatics. These genetic markers can be important source of asthma risk in Pakistani population.


Pakistan Journal of Zoology | 2014

Study of β-Lactoglobulin Milk Protein Variants in Buffalo

Iffat Tahira; Abid Mahmood; Muhammad Saqlain; Nafeesa Qudsia Hanif; Ghazala Kaukab Raja


Archive | 2014

IMPACT OF TYPE AND PARTICLE SIZE ON THE PROTEIN CONTENTS IN WHEAT FLOUR

Muhammad Asif Hanif; Mansoor Khan Khattak; Saqib Khan; Muhammad Saeed; Abdullah Khan; Muhammad Saqlain


Scientific Inquiry and Review | 2018

Consumer’s Perception and Impact of pH on Detergent in Automatic Washing Machine Based on Fuzzy Logic Controller

Muhammad Saeed; Muhammad Saqlain; Naveed Jafar


Pakistan Journal of Zoology | 2018

Association of Intestinal Fatty Acid Binding Protein (FABP2) Polymorphism with Metabolic Syndrome Risk

Muhammad Saqlain; Humaira Kalsoom; Muhammad Fiaz; Abid Mahmood; Rizwan Aziz Qazi; Waseem Safdar; Pakeeza Arzoo Shaiq; Bernard M.Y. Cheung; Ghazala Kaukab Raja


Kafkas Universitesi Veteriner Fakultesi Dergisi | 2016

Comparison of the common immunogenic protein components of Pasteurella multocida serotypes B:2 and B:3,4.

Rizwana Abdul Ghani; N. A. Khattak; Muhammad Saqlain; Muhammad Javaid Asad; Azra Khanum; Sm Saqlan Naqvi; Ghazala Kaukab Raja


Kafkas Universitesi Veteriner Fakultesi Dergisi | 2016

Pasteurella multocida B:2 ve B:3,4 Serotiplerinin Ortak İmmunojenik Protein Komponentlerinin Karşılaştırılması

Rizwana Abdul Ghani; Naureen Aslam Khattak; Muhammad Saqlain; Muhammad Javaid Asad; Azra Khanum; Syed Muhammad Saqlan Naqvi; Ghazala Kaukab Raja


Archive | 2015

Effect of Drying Temperature and Natural Preservatives on Reducing Aflatoxins in Solar Dried Persimmon (Diospyros kaki L)

Muhammad Asif Hanif; Mansoor Khan Khattak; Masood U. Rehman; Muhammad Aamir; Shaiza S. Sher; Saqib Khan; Muhammad Saeed; Abdullah Khan; Muhammad Saqlain


17th European Congress of Endocrinology | 2015

Reduction of growth and lesser utilisation of energy reserves in heroin addicted boys during pubertal development

Muhammad Saqlain; Ghazala Kaukab Raja; M. Akram; Samar Minallah; Afzaal Ahmad; Mazhar Qayyum; S S R Rizvi

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Ghazala Kaukab Raja

Pir Mehr Ali Shah Arid Agriculture University

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Muhammad Fiaz

University of Veterinary and Animal Sciences

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Muhammad Javaid Asad

Pir Mehr Ali Shah Arid Agriculture University

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Amber Nawaz

Pakistan Institute of Medical Sciences

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Amna Noor

Rawalpindi Medical College

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Asad Rasool

Pir Mehr Ali Shah Arid Agriculture University

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Azra Khanum

Pir Mehr Ali Shah Arid Agriculture University

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Iffat Tahira

Pir Mehr Ali Shah Arid Agriculture University

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