Muhammad Saqlain
Pir Mehr Ali Shah Arid Agriculture University
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Featured researches published by Muhammad Saqlain.
Gene | 2018
Madiha Khalid; Terri M. Driessen; Jong Seo Lee; Leon Tejwani; Asad Rasool; Muhammad Saqlain; Pakeeza Arzoo Shiaq; Muhammad Hanif; Amber Nawaz; Andrew T. DeWan; Ghazala Kaukab Raja; Janghoo Lim
Many single nucleotide polymorphisms (SNPs) have been identified for Bipolar disorder (BD), but association between SNPs and BD can vary depending on the population tested. SNPs rs10994336 and rs9804190 in ANK3 and rs1006737 in CACNA1C have emerged as the most highly replicated SNPs significantly associated with BD. The aim of the present study was to assess the association of these SNPs with BD in the Pakistani population, which has never before been examined. A total of 120 BD and 120 control individuals from Pakistan were examined in this analysis. Genotyping results indicated that rs1006737 in CACNA1C was significantly associated with BD, while rs10994336 or rs9804190 in ANK3 was not significant when examined individually. However, risk score assessment found that the presence of two or more risk alleles was significantly associated with disease, indicating that risk alleles from ANK3 and CACNA1C may additively contribute to BD. A protein-protein interaction network was generated using STRING to probe the relationship between ANK3 and CACNA1C interactors and their associations with BD. While none of the interactors are directly linked to BD, they play a role in pathways linked to BD, including oxytocin and dopamine signaling pathways. Collectively, these results reveal a significant association of CACNA1C with BD among the Pakistani population, extending results from other ethnic groups to the Pakistani population for the first time.
Asthma Research and Practice | 2018
Nusrat Saba; Osman Yusuf; Sadia Rehman; Saeeda Munir; Amna Noor; Muhammad Saqlain; Atika Mansoor; Ghazala Kaukab Raja
BackgroundGenetic variations in different loci and genes are important in asthma pathogenesis. There is much importance of various immunological pathways in the IgE secretion regulation. Alterations in any main part of these pathways can increase the risk of asthma development. Polymorphisms in these genetic markers can effect certain pathways which predict the asthma susceptibility. In the present study, SNPs directly or indirectly affecting the immunological process pathways are selected.MethodsThis study was conducted to determine association of 16 SNPs in 10 candidate genes with asthma in Pakistani population in 333 asthmatic cases and 220 healthy controls. Genotyping was performed using the Sequenom Mass ARRAY iPLEX platform (14 SNPs) and TaqMan assay (2 SNPs).ResultsThe minor allele at two of the SNPs showed association with protection from asthma, rs1131882 in TBXA2R gene (OR 0.73, 95% CI 0.52–1.01, P = 0.05) and rs2280091 in the ADAM33 gene (OR 0.69, 95% CI 0.50–0.97, P = 0.03). For FCER1B gene, rs2583476 the asthmatic male gender had higher TT genotype counts as compared to controls (OR = 1.86, 95% CI = 1.09–3.17, p = 0.01). In rs11650680 of ORMDL3 gene the CT genotype is more prevalent in female asthma cases in comparison with female controls (OR = 1.99, 95% CI = 1.02–3.89, p = 0.03).ConclusionsThis data suggests that variations at TBXA2R and ADAM33 genes are found to be associated with asthma susceptibility in Pakistan. FCER1B gene is associated with male and ORMDL3 in female asthmatics. These genetic markers can be important source of asthma risk in Pakistani population.
Pakistan Journal of Zoology | 2014
Iffat Tahira; Abid Mahmood; Muhammad Saqlain; Nafeesa Qudsia Hanif; Ghazala Kaukab Raja
Archive | 2014
Muhammad Asif Hanif; Mansoor Khan Khattak; Saqib Khan; Muhammad Saeed; Abdullah Khan; Muhammad Saqlain
Scientific Inquiry and Review | 2018
Muhammad Saeed; Muhammad Saqlain; Naveed Jafar
Pakistan Journal of Zoology | 2018
Muhammad Saqlain; Humaira Kalsoom; Muhammad Fiaz; Abid Mahmood; Rizwan Aziz Qazi; Waseem Safdar; Pakeeza Arzoo Shaiq; Bernard M.Y. Cheung; Ghazala Kaukab Raja
Kafkas Universitesi Veteriner Fakultesi Dergisi | 2016
Rizwana Abdul Ghani; N. A. Khattak; Muhammad Saqlain; Muhammad Javaid Asad; Azra Khanum; Sm Saqlan Naqvi; Ghazala Kaukab Raja
Kafkas Universitesi Veteriner Fakultesi Dergisi | 2016
Rizwana Abdul Ghani; Naureen Aslam Khattak; Muhammad Saqlain; Muhammad Javaid Asad; Azra Khanum; Syed Muhammad Saqlan Naqvi; Ghazala Kaukab Raja
Archive | 2015
Muhammad Asif Hanif; Mansoor Khan Khattak; Masood U. Rehman; Muhammad Aamir; Shaiza S. Sher; Saqib Khan; Muhammad Saeed; Abdullah Khan; Muhammad Saqlain
17th European Congress of Endocrinology | 2015
Muhammad Saqlain; Ghazala Kaukab Raja; M. Akram; Samar Minallah; Afzaal Ahmad; Mazhar Qayyum; S S R Rizvi