Mukesh Choudhary

Syntheses, characterizations, crystal structures, antibacterial and SOD-like activities of nickel(II) and copper(II) complexes with 2-((Z)-(4-methoxyphenylimino)methyl)-4,6-dichlorophenol

Abstract Three mononuclear nickel(II) and copper(II) complexes, [Ni(L)2(py)2] (1), [Ni(L)2(DMF)(H2O)] (2), and [Cu(L)2] (3), where HL = 2-((Z)-(4-methoxyphenylimino)methyl)-4,6-dichlorophenol, py = pyridine and DMF = N,N-dimethylformamide, have been synthesized and their structures determined by single crystal X-ray analysis. Complexes 1–3 crystallized in the monoclinic system of the space groups C2/c, P21/n, and P21/c, respectively. The crystal structures of 1 and 2 present an octahedral geometry at the metal center and 3 shows a square-planar geometry. The FT-IR spectra, UV–vis spectra, and magnetic susceptibility measurements agree with the observed crystal structures. EPR spectra indicate a dx2–y2 ground state (g|| > g⊥ > 2.0023 and A|| > A⊥) for 3 at RT and LNT. The results of simultaneous TG-DTA analyses of 1 and 3 showed the final degradation products are NiO for 1 and CuO for 3. The Schiff base (HL) behaves as monobasic bidentate ligand possessing N and O donor atoms. Electrochemical properties for the complexes are similar and involve two irreversible redox processes. Complex 3 exhibits the ability to inhibit jack bean urease, although its Schiff base has no ability to inhibit urease. Complex 1 exhibits more active scavenging effects against O2− than HL, 2 and 3 under the same conditions. Antibacterial screening activities of these complexes were also investigated.

Syntheses, crystal structures, DFT, molecular docking and inhibition studies of jack been urease by nickel (II) and copper (II) Schiff base complexes

Abstract Ni (II) and Cu (II) complexes [Ni(L)2] (1) and [Cu(L)2].H2O (2) was synthesized using a Schiff base (HL) ligand which was formed by 5-bromosalicylaldehyde with 2-methoxybenzeneamine. The crystal structure of the ligand and its complexes were determined through crystal X-ray diffraction. The most plausible geometry for the 1:2 complexes appeared to be distorted octahedral. The TG–DTA analysis of complex (1) and (2) exhibits an exothermic peaks at around 367–393 °C. Their inhibition studies was performed on urease. Complex (1) and (2) can inhibit urease activity, with IC50 values of 2.10 ± 0.06 and 2.10 ± 0.10 µmol L−1, respectively. Their DFT study were also discussed.