Muneto Mogi
Bayer
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Publication
Featured researches published by Muneto Mogi.
Bioorganic & Medicinal Chemistry Letters | 2011
Klaus Urbahns; Takeshi Yura; Muneto Mogi; Masaomi Tajimi; Hiroshi Fujishima; Tsutomu Masuda; Nagahiro Yoshida; Toshiya Moriwaki; Timothy B. Lowinger; Heinrich Meier; Fiona Chan; David Madge; Jang Bahadur Gupta
We have identified naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 by high throughput screening. The initial lead showed high clearance in rats and has been optimized by enhancing the acidity of the phenol group. Compound 6b has reduced clearance, improved potency and is active in rat cystometry models of urinary incontinence after intravenous administration.
Bioorganic & Medicinal Chemistry Letters | 2012
Klaus Urbahns; Takeshi Yura; Jang Bahadur Gupta; Masaomi Tajimi; Hiroshi Fujishima; Tsutomu Masuda; Noriyuki Yamamoto; Yuka Ikegami; Makiko Marumo; Kayo Yasoshima; Nagahiro Yoshida; Toshiya Moriwaki; David Madge; Fiona Chan; Muneto Mogi
Starting from a naphthol-based lead series with low oral bioavailability, we have identified potent TRPV1 antagonists with oral bioavailability in rats. These compounds emerged from SAR studies aimed at replacing the leads phenol structure whilst maintaining potency. Compound rac-6a is an orally available TRPV1 antagonist with single-digit nanomolar activity. The enantiomers show a low eudismic ratio at the receptor level.
Archive | 2001
Takeshi Yura; Arnel Concepcion; Gyoonhee Han; Makiko Marumo; Hiroko Yoshino; Norihiro Kawamura; Toshio Kokubo; Hiroshi Komura; Yingfu Li; Timothy B. Lowinger; Muneto Mogi; Noriyuki Yamamoto; Nagahiro Yoshida; Scott Miller; Margaret A. Popp; Aniko M. Redmann; Martha E. Rodriguez; William J. Scott; Ming Wang
Archive | 2003
Masaomi Tajimi; Toshio Kokubo; Masahiro Shiroo; Yasuhiro Tsukimi; Takeshi Yura; Klaus Urbahns; Noriyuki Yamamoto; Muneto Mogi; Hiroshi Fujishima; Tsutomu Masuda; Nagahiro Yoshida; Toshiya Moriwaki
Archive | 1999
Joachim Mittendorf; Rolf Henning; Siegfried Raddatz; Karl-Heinz Schlemmer; Makiko Hiraoka; Hiroshi Kadono; Muneto Mogi; Toshiya Moriwaki; Toshiki Murata; Sachiko Sakakibara; Mitsuyuki Shimada; Nagahiro Yoshida; Takashi Yoshino
Archive | 2004
Axel Bouchon; Nicole Diedrichs; Achim Hermann; Klemens Lustig; Heinrich Meier; Josef Pernerstorfer; Elke Reissmüller; Vry Jean Dr De; Muneto Mogi; Klaus Urbahns; Takeshi Yura; Hiroshi Fujishima; Masaomi Tajimi; Noriyuki Yamamoto; Hiroaki Yuasa; Jang Bahadur Gupta; Yasuhiro Tsukimi; Fumihiko Hayashi
Archive | 2003
Masaomi Tajimi; Toshio Kokubo; Masahiro Shiroo; Yasuhiro Tsukimi; Takeshi Yura; Noriyuki Yamamoto; Muneto Mogi; Hiroshi Fujishima; Tsutomu Masuda; Nagahiro Yoshida; Toshiya Moriwaki; Klaus Urbahns
Archive | 2003
Hiroshi Fujishima; Toshio Kokubo; Tsutomu Masuda; Muneto Mogi; Toshiya Moriwaki; Masahiro Shiroo; Masaomi Tajimi; Yasuhiro Tsukimi; Klaus Urbahns; Noriyuki Yamamoto; Nagahiro Yoshida; Takeshi Yura
Archive | 2003
Takeshi Yura; Muneto Mogi; Klaus Urbahns; Hiroshi Fujishima; Tsutomu Masuda; Toshiya Moriwaki; Nagahiro Yoshida; Toshio Kokubo; Masahiro Shiroo; Masaomi Tajimi; Yasuhiro Tsukimi; Noriyuki Yamamoto
Archive | 2003
Masaomi Tajimi; Toshio Kokubo; Masahiro Shiroo; Yasuhiro Tsukimi; Takeshi Yura; Noriyuki Yamamoto; Muneto Mogi; Hiroshi Fujishima; Tsutomu Masuda; Nagahiro Yoshida; Toshiya Moriwaki; Klaus Urbahns
