Murat Uncu

Evaluation of Thyroid Autoimmunity in Gestational Diabetes Mellitus

The aim of our study was to determine if there is any association between autoimmune thyroid diseases in patients with gestational diabetes. A total of 180 healthy pregnant women (control) and 45 pregnant women with gestational diabetes mellitus (study group) were enrolled in the study. We could not determine any association between gestational diabetes mellitus and thyroid autoimmunity in pregnant.

Is calprotectin a marker of tobacco smoke related inflammation?: a pilot study in children

Context: Environmental tobacco smoke (ETS) related inflammation has an anorexigenic effect through affecting the release of appetite-modulating mediators, leptin and ghrelin. Elevated serum calprotectin levels are found in a variety of inflammatory conditions. Objective: To study the relation between ETS and body mass index (BMI), as well as serum levels of leptin, ghrelin and calprotectin. Materials and methods: A cross-sectional study was performed by searching the smoking status of parents. After filling in the questionnaires, parents were phoned and children were invited to supply fasting blood samples in order to measure serum levels of leptin, ghrelin and calprotectin, and to calculate their BMIs. Participant children were divided into Group 1 (n = 51), those who are not exposed to and Group 2 (n = 46), exposed to indoor ETS. Results: There were no statistical difference in BMI, leptin and ghrelin levels between Group 1 and Group 2 (p values are 0.85, 0.87 and 0.42, respectively), but serum calprotectin levels were statistically higher in Group 2 (p = 0.003). Discussion and conclusion: In this study serum levels of calprotectin were found to be higher in children with indoor ETS exposure where no relation was detected with BMI and serum levels of leptin and ghrelin. Increased serum levels of calprotectin might be an indicator of inflammation related to ETS exposure.

High prenatal exposure to bisphenol A reduces anogenital distance in healthy male newborns.

Objective: To estimate the relationship between cord blood bisphenol A (BPA) levels and anogenital measurements in healthy newborns. Methods: Pregnancy and birth history, together with body mass and length data, anogenital measurements, penile measurements and cord blood samples were obtained from healthy newborns. Cord blood concentration of BPA was analyzed by sandwich enzyme-linked immunosorbent assays kit. Results: Among 130 healthy newborns (72 boys, 58 girls), mean anopenile distance was 45.2±6 mm and anoscrotal distance was 21.9±5.4 mm in boys; mean anoclitoral distance was 33.8±6.6 mm and mean anofourchette distance was 12.2±4.9 mm in girls. Mean cord blood BPA level was 4.75±2.18 ng/mL. 90th percentile value for cord blood BPA was 8.26 ng/mL and the analysis showed a statistically significant correlation between anoscrotal distance and cord blood BPA levels above the 90th percentile (p=0.047) in boys. The changes in anogenital distance in girls were not statistically significant. Conclusion: We showed a significant association between high cord blood BPA levels and shortened anoscrotal distance in male newborns. However, this result should be interpreted with caution since there were no significant external genital abnormalities in our study group.

Effect of isotretinoin on prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT)

Abstract Patients with severe acne may need elective/urgent surgical interventions during treatment with isotretinoin and it is critical for the surgeon to consider the possible effects of this medication on coagulation systems. The aim of this study is to determine the changes in prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT) during isotretinoin treatment. PT, aPTT, and INR values of 51 severe acne patients were evaluated during routine pre-treatment biochemical analysis. Only patients with normal values were included in the study. The results of before and after 1 month treatment were compared statistically. There were no statistically significant change in mean alanine aminotranferease (ALT), aspartate aminotransferase (AST), PT, and INR values after treatment. A significant increase in aPTT was detected. The INR values, which are more trusted and safe, showed no difference. Isotretinoin seems to have no effect on these coagulation parameters.

PO-0672 Cord Blood Osteocalcine, Leptin And Tnf? Levels In Gestational Diabetic Pregnancies

Aim To compare cord blood osteocalcin, leptin and TNF α levels in gestational diabetic and normal pregnancies. Method 191 deliveries were included in this research. 41 (21.5%) of pregnancies were gestational diabetic and 159 (78.5%) of pregnancies were normal. Cord blood osteocalcin, leptin and TNF α levels were compared. Results There was no significant difference among birth weights (p:0.409), heights (p:0.07), head circumferences (p 0.201), gender (p:0.4), gestational weeks (p:0.201), ponderal index (0.564) between groups. There was no significant difference between groups regarding pregnancy complications. However, hypothyroidism was more common in gestational diabetic group (p:< 0.001). In addition, hypoglycemia was more common in gestational diabetic group (p:0.047). Gestational diabetic group’s cord blood osteocalcin levels were higher than in non diabetic group (p:0.037). Cord blood TNF α (p:0.813) and leptin average levels (p: 0,212) were not statistically different. Osteocalcin, leptin and TNF α levels were not statistically different between boys and girls. Discussion Osteocalcin; originating from bones, increases insulin sensitivity in peripheral organs and insulin secretion. Leptin is known to inhibit insulin and osteocalcin secretion. Osteocalcin level increase in gestational diabetic group, may be related to osteocalcin regulation of blood glucose levels. Cord blood leptin and TNF α levels showed no significant difference between groups, probably due to proper regulation of cord blood glucose levels during gestation.