Murat Ziyrek

Epicardial Adipose Tissue Increased in Patients with Newly Diagnosed Subclinical Hypothyroidism

Objective: To investigate whether or not patients with subclinical hypothyroidism (SH) have increased epicardial adipose tissue (EAT). Subjects and Methods: Sixty-one patients with newly diagnosed SH and without any known cardiovascular disease were enrolled. Twenty-four subjects matched for age, gender and body mass index without any thyroid dysfunctions were included as a control group. The EAT was measured by echocardiography and thyroid functions were assessed by routine blood examination. Results: Patients with SH had higher EAT values than control subjects (3.6 ± 0.9 vs. 2.8 ± 1.4, p = 0.005). Also, SH patients with thyroid-stimulating hormone (TSH) ≥10 mU/l had higher EAT than those with SH with TSH <10 mU/l and control subjects (p = 0.013). In addition, while there was significant correlation between EAT and TSH (r = 0.31, p = 0.014) in patients with SH, there was no significant relation between EAT and TSH in normal subjects (r = 0.09, p = 0.64). Conclusions: There was a higher level of EAT in patients with SH compared with normal subjects and a significant correlation between EAT and TSH was found.

Diagonal earlobe crease associated with increased epicardial adipose tissue and carotid intima media thickness in subjects free of clinical cardiovascular disease

OBJECTIVE Atherosclerotic coronary artery disease is a leading cause of death, worldwide. Diagonal earlobe crease (DELC) has been suggested as a simple, noninvasive marker of cardiovascular disease. Although epicardial adipose tissue (EAT) thickness and carotid intima media thickness (CIMT) are closely related to atherosclerosis, the relation between EAT, CIMT, and DELC had yet to be studied. The present objective was to analyze this association. METHODS Subjects were apparently healthy individuals referred to the cardiology outpatient clinic. A total of 65 subjects with DELC and 65 age- and sex-matched controls without DELC were enrolled. EAT thickness and CIMT were measured and analyzed. RESULTS Epicardial adipose tissue thickness was significantly higher in the DELC group (0.57±0.12 vs. 0.35±0.05; p<0.0001). CIMT was also significantly higher in DELC group (0.85±0.16 vs. 0.60±0.15; p<0.0001). Correlation analysis showed that CIMT was significantly correlated with EAT thickness (r: 0.594; p<0.0001). Linear regression analysis showed that presence of DELC was independently associated with CIMT and EAT thickness. CONCLUSION A significant and independent association between the presence of DELC and increased CIMT and EAT thickness was presently determined, for the first time, in subjects free of clinical cardiovascular disease.

Hardly Treated Infective Endocarditis Case Accompanied by Severe Erithrodermia

DOI: 10.4328/JCAM.1177 Received: 29.06.2012 Accepted: 12.09.2012 Printed: 01.11.2013 J Clin Anal Med 2013;4(suppl 3): 340-2 Corresponding Author: Murat Ziyrek, Özel Yıldızlı Güven Hastanesi Kardiyoloji Bölümü, Devlet Sahil Yolu Cad. No: 46 Yıldızlı Beldesi, Akcaabat, Trabzon, Türkiye. T.: +90 462446101 F.: +90 4622481828 E-Mail: muziyrek@yahoo.com Özet Enfektif endokardit (EE), sık görülmemesine rağmen yüksek mortalite ve morbiditeye neden olabilen, çoğunlukla cerrahi müdahale gerektiren önemli bir hastalıktır. Eritrodermi özellikle yaşlılarda metabolik komplikasyonlara bağlı mortal seyredebilen dermatolojik acil durumlardan birisidir. Bu yazıda, medikal tedavi sonrası şiddetli eritrodermi gelişen fakat cerrahi müdahale gereksinimi olmaksızın tedavi edilen bir akut EE vakası sunulmuştur.

Transtorasik Ekokardiyografi de Nekrotik/ Fibrotik Miyokart İçermeyen Hastalarda Cerrahi Revaskülarizasyonun QT Dispersiyon Süresi Üzerine Etkisi

Introduction: Prolonged QT dispersion time is known to be associated with cardiac arrhythmias and sudden cardiac death. It was proved previously that electrical heterogenity caused by myocardial ischemia, hypertrophic cardiomyopathy, electrolyte imbalance, heart failure prolongs QT dispersion time. The aim of this study was to investigate the effect of surgical revascularization on QT dispersion time in ischemic patients not having necrotic/fi brotic segments in transthoracic echocardiography. Patients and Methods: Data of patients treated with surgical revascularization due to coronary artery disease are evaluated retrospectively. 247 patients were enrolled into the study after application of exclusion criteria. Patients’ electrocardiographic records were evaluated and values of preoperative (QTcd0), postoperative fi rst (QTcd1), postoperative third (QTcd3) and postoperative seventh (QTcd7) day corrected QT dispersion time calculated and compared with each other. Results: There were statistically signifi cant differences between QTcd0 (83.6 ± 2.2) and QTcd1 (55.3 ± 1.7), QTcd3 (50.4 ± 1.2) and QTcd7 (45.3 ± 1.1) (p< 0.001, p< 0.001, p< 0.001 respectively). There was also statistically signifi cant difference between QTcd1 (55.3 ± 1.7) and QTcd7 Yazışma Adresi/ Correspondence