Musa Özil

Synthesis of novel triazol compounds containing isatin as potential antibacterial and antifungal agents by microwave and conventional methods

Microwave irradiation has been used to accelerate the conversion of isatin (1a) and 5-nitroisatin (1b) into their Schiff bases 3-[5’-aryl(alkyl)-2’,4’-dihydro-1’,2’,4’-triazol-3’-on-4’-yl]iminoisatin (3a–g) and 3-[5’-aryl(alkyl)-2’,4’-dihydro-1’,2’,4’-triazol-3’-on-4’-yl]imino-5-nitroisatin (4a–g), respectively. Reaction was achieved by microwave-induced technique, which reduced the reaction time drastically and improved the yield when compared to conventional heating. The newly synthesised bases showed moderate antimicrobial activity against the standard bacterial and fungal organisms tested

4,4′-(4,4′-Thio­di­phenoxy)­diphthalo­nitrile

The title compound, C28H14N4O2S, contains four aromatic rings, and the crystal structure is stabilized by π–π stacking.

4-Di­phenyl­methoxy­phthalo­nitrile

The title compound, C21H14N2O, contains three aromatic rings. The structure is stabilized by π–π stacking interactions.

12,13-Di­hydro-12-oxo-13-phenyl­benzo­[b]­naphth­[f][1,4]­oxazepine-2,3-dicarbo­nitrile

The crystal structure of the title compound, C25H13N3O2, is stabilized only by weak van der Waals interactions. The seven-membered ring has a boat conformation.