Myoung-Ja Chung

Propofol attenuates ischemia-reperfusion injury in the isolated rat heart

The purpose of this study was to examine the direct effects of propofol on ischemia-reperfusion injury using an isolated Langendorff rat heart preparation. Hearts were perfused with Krebs-Henseleit (K-H) solution (control); intralipid; or 10, 30, and 100 micro M propofol. Hearts were rendered globally ischemic for 25 min, then reperfusion was begun with K-H solution for 30 min. Treatment with 100 micro M propofol delayed the onset of contracture during ischemia compared with control or intralipid treatments (6.4 +/- 2.1 vs 4.4 +/- 1.4 or 4.1 +/- 0.7 min, respectively; P < 0.05). During reperfusion, 100 micro M propofol increased coronary flow and reduced lactate dehydrogenase release compared with control or intralipid treatments. After 30 min of reperfusion, left ventricular developed pressure (LVDP) returned to 55 and 76 mm Hg in the 30 and 100 micro M propofol-treated groups, respectively, whereas LVDP was 39 mm Hg in the control group. The hearts treated with 100 micro M propofol showed significantly lower left ventricular end-diastolic pressure compared with the control or intralipid groups 30 min after reperfusion (29 +/- 13 vs 48 +/- 5 or 48 +/- 11 mm Hg, respectively; P < 0.05). In histological evaluation, control and intralipid hearts had increased injury severity scores compared with hearts treated with 100 micro M propofol (1.8 +/- 0.9 and 1.7 +/- 0.8 vs 1.0 +/- 0.7, respectively; P < 0.05). In conclusion, we suggest that propofol administered before and during global myocardial ischemia has cardioprotective effects on ischemia-reperfusion injury. Implications: It is important to protect the heart from injury by ischemia and reperfusion. The current study demonstrates that in the isolated rat heart, propofol attenuates mechanical, biochemical, and histological changes causes by ischemia and reperfusion. (Anesth Analg 1997;85:719-24)

Adenomyoma of the small intestine: report of two cases and review of the literature.

Adenomyoma of the small intestine is a rare tumor‐like lesion composed of exocrine‐type ducts and hypertrophic smooth muscle. We describe two cases of adenomyoma of the small intestine. One was an ileal adenomyoma that presented with intussusception occurring in a 7‐month‐old boy. The other was a jejunal adenomyoma found incidentally in a 63‐year‐old man with colon cancer. Histologically, the lesions composed of benign ducts and bundles of smooth muscle. The second case was detected on contrast‐enhanced computed tomography scan as a small enhancing polypoid mass. We review the previous literature of adenomyoma of the small intestine.

The involvement of endoplasmic reticulum stress in flavonoid-induced protection on cardiac cell death caused by ischaemia/reperfusion

Objectives We have investigated whether endoplasmic reticulum stress and Bcl‐2 proteins were linked to the protective effect exerted by flavonoids on ischaemia/reperfusion‐induced cardiac damage.

Phyllodes tumor of the seminal vesicle: case report and literature review.

A 39‐year‐old man presented with urinary retention and lower abdominal discomfort at our hospital, and a computed tomography scan showed a huge cystic mass posterior to the urinary bladder. During surgical exploration, a mass superior to the prostate in the region of the left seminal vesicle was found. Histologically, the tumor was characterized by cystically dilated or slit‐like glands mixed in a densely cellular stroma with pleomorphism and resembled those of phyllodes tumor of the breast or prostate. The glandular epithelium within the tumor showed focal lipofuscin pigment and negative staining for prostate specific antigen (PSA). The stromal cells showed positive immunoreactivity for vimentin and CD34, and focal positive reactions for desmin and α‐smooth muscle actin. Mitosis was present 0 to 1 per 10 high power fields of magnification in the stromal cells. Approximately 20% of the stromal cells were positive for progesterone receptor. The patient is alive with no evidence of disease 12 months after surgery. Mixed epithelial‐stromal tumors of the seminal vesicle are extremely rare. A combination of stromal cellularity, atypia and mitosis might be used for the histological grading, and a prostatic origin might be excluded by the location of the primary lesion itself and by the failure to show PSA.

'Hot liver' on 18F-FDG PET/CT imaging in a patient with hepatosplenic tuberculosis.

A 69-year-old woman with suspected lymphoma had an F-FDG PET/CT scan, which showed mild hepatosplenomegaly with increased FDG uptake in the liver, spleen, and multiple lymph nodes in the chest and abdomen (a). Especially hepatic activity was diffuse and intense (b). However, there were no hepatic masses or parenchymal abnormalities on enhanced CT scan (c). All liver enzymes were markedly elevated (alanine aminotransferase: 113 IU/l, aspartate aminotransferase: 177 IU/l, alkaline leukocyte phosphatase: 1,539 IU/l). A viral work-up for hepatitis was negative. A splenectomy with biopsies of the liver, spleen and lymph nodes was performed. Multiple, well-formed granulomas with central caseation necrosis were noted in the liver, spleen and lymph nodes, and acid-fast bacilli were

Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer.

Abstract:Struma ovarii is an ovarian tumor containing thyroid tissue as a predominant cell type. Malignant transformation is rare. The cervical thyroid is usually found to be normal on histology. In a patient who had previously undergone thyroidectomy because of papillary thyroid cancer, we report a

Sclerosing hemangioma, presenting as a pneumonic pattern with mucinous adenomatous hyperplasia of the lung

Pulmonary sclerosing hemangioma is generally considered a rare neoplasm presenting as a solitary benign nodule. During routine medical examination multiple abnormal nodular shadows were detected in the right lower lung field on chest X‐ray in a 48‐year‐old asymptomatic woman. The patient underwent wedge resection for the pulmonary lesion. The resected lung had numerous scattered tiny nodules and small nodules congregated together, forming larger nodules. All of these lesions had typical features of sclerosing hemangioma. The authors call this unusual growth pattern of sclerosing hemangioma a ‘pneumonic pattern’. Adjacent to the largest lesion, a relatively well‐defined small mucinous lesion composed of mucinous tall columnar cells and basaloid squamous cells was detected. Because this lesion did not have expression of thyroid transcription factor‐1, it is described as mucinous adenomatous hyperplasia.

F-18 FDG PET/CT findings of huge cholesterol granuloma in multiple ribs.

Abstract:Cholesterol granuloma (CG) is a foreign body-type granuloma formed in reaction to cholesterol crystals. CG usually develops in pneumatized bones because of inadequate drainage, especially in the middle ear cavity. We report a case of a patient with huge CG involving multiple ribs. A 66-year