Nadia Ali Ahmed Elkanzi

Green chemistry: microwave-assisted facile synthesis of 6-imino-1,3,4-thiadiazenes from reaction of thiocarbohydrazones with malononitrile dimer

ABSTRACT The reactions of thiocarbohydrazones with malononitrile dimer under microwave irradiation are reported. These reactions give 6-imino-1,3,4-thiadiazines in good yields. The structures of products were elucidated by MS, IR and NMR spectra together with elemental analyses. The reaction mechanism was discussed. GRAPHICAL ABSTRACT

Synthesis and studies molecular docking of some new thioxobenzo[g]pteridine derivatives and 1,4-dihydroquinoxaline derivatives with glycosidic moiety

ABSTRACT The present work is mainly dedicated to heterocyclic compounds as well as S-glycoside. 1,4-dihydroquinoxaline derivatives 3 were obtained from the reaction 2 with carbon disulfide in presence of potassium hydroxide. S-glycoside 4 was prepared from the reaction of compound 3 with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide. Several heterocyclic derivatives containing thioxobenzo[g]pteridine ring systems were obtained starting from ethyl 3-amino-1,4-dihydroquinoxaline-2-carboxylate 1. These newly synthesized compounds were docked within the active site of cyclooxygenase-2 (COX-2). The results of this docking study revealed that the new compounds might exhibit good anti-inflammatory activity. The structure of new compounds was demonstrated by elemental analysis, IR, 1H NMR spectra and mass spectra.